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Tracking Inline Cell Count and Dimension to Ensure Targeted Cell Culture Productivity

This online seminar will introduce tools used in fermentation and outline a number of academic and industrial case studies on fermentation processes including E. Coli, mammalian cells, plant cells and filamentous organisms. Inline Process Analytical Technology (PAT) has become critical to ensuring productivity in the biotechnology industry. Return on investment in Process Analytical Technology (PAT) comes from R&D and manufacturing. Typically, this is achieved by getting more robust processes to market quicker which ultimately minimizes the process risks from batch to batch and also improves process optimization. With the advent of in-process Process Analytical Technology (PAT) tools for particle/cell characterization one can quantify particle/cell number and dimension in applications such as fermentation, separation, and formulation. Application examples include: Ensure cell culture productivity by detecting the mode of cell death (apoptosis) through changes in cell number and dimension Monitor cell count, cell density in real time with no need for sampling Study cell debris and cell debris flocculation Streamline scale-up from shaker flasks to the pilot scale Optimized protein crystallization.

Type of Event: On-Demand Webinars
By appointment: Yes
Language: English
Topics:
  • process analytical technology
  • fermentation
  • separation
  • protein crystallization
  • process optimization
  • mammalian cells
  • flocculation
  • cells
  • cell density
  • cell death
  • biotechnology
  • apoptosis

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