Inline Process Analytical Technology (PAT) has become critical in ensuring process robustness and productivity in the biotechnology industry. By implementing in situ probe based particle measurement technology, real time changes can be tracked to the floc size distribution while measuring i ... more
Online Monitoring of MicroEncapsulation
The main factors that affect the microencapsulation procedure and final microparticles are: Matrix material level, composition, and inherent viscosity Physiochemical properties of the active ingredient being entrapped Matrix/active ingredient ration Nature of the solvent employed Level and properties of the stabilizer used Shearing stress and the temperature of the emulsification A MicroEmulsion example from the US Food and Drug Administration (FDA) is used during the presentation to show how to: Understand the droplet system's response when changing process parameters. Optimize the process by choosing conditions which ensure consistent endpoints, batch repeatability and process stability. Scale-up the particle distribution while avoiding batch failure or inconsistency process performance and product quality.
|Type of Event:||On-Demand Webinars|