My watch list


Designing Continuous Crystallization Platforms

A continuous crystallization platform was developed that allowed Process Analytical Technologies (PAT) to be applied in situ via the use of novel flow cells. This crystallization platform was used to develop the anti-solvent crystallization of benzoic acid from aqueous ethanol solution. 2, 3 The equivalent tank based Mixed-Suspension, Mixed-Product-Removal (MSMPR) crystallization was also characterized using PAT in a continuous stirred tank utilizing a pneumatic slurry transfer technique. 1,4,5 These continuous crystallizations were compared to the equivalent batch crystallizations so that a true measure of performance of the continuous crystallizations could be made. 1 As expected the continuous crystallizations offered hugely intensified production with approximately the same amount of material generated by a ~40 ml plug flow, 9 L MSMPR and 42, 10,000 L batch crystallizations per annum. Furthermore, the alternate process dynamics and mixing environments offered by the plug flow and MSMPR enabled a wider range of particle sizes and morphologies to be produced than would be available if only the batch crystallization options were considered. 1,3 Use of in situ PAT permits significant reductions in process development time and can also be applied to monitoring and control of continuous industrial crystallizations. It is hoped that such methods can facilitate the inclusion of continuous crystallizer configurations in standard pharmaceutical commercialization procedures. Guest

Type of Event: On-Demand Webinars
By appointment: Yes
Language: English

More about Mettler-Toledo

Topics A-Z

All topics

q&more – the networking platform for quality excellence in lab and process

The q&more concept is to increase the visibility of recent research and innovative solutions, and support the exchange of knowledge. In the broad spectrum of subjects covered, the focus is on achieving maximum quality in highly innovative sectors. As a modern knowledge platform, q&more offers market participants one-of-a-kind networking opportunities. Cutting-edge research is presented by authors of international repute. Attractively presented in a high-quality context, and published in German and English, the original articles introduce new concepts and highlight unconventional solution strategies.

> more about q&more

q&more is supported by:

Your browser is not current. Microsoft Internet Explorer 6.0 does not support some functions on Chemie.DE