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Call for standards of epigenetic data

02-Oct-2018

At the heart of every cell is the nucleus, which acts as the cell’s control center. Recent studies have revealed more and more information about its organization and dynamics. However, the rapid development of methods and the increasing complexity of the collected data pose major challenges. ...

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New insight into the maturation of miRNAs

04-Jul-2018

An international research team led by Helmholtz Zentrum München, Technical University of Munich and the University of Edinburgh has used an integrated structural biological approach to elucidate the maturation of a cancer-causing microRNA in gene regulation. In the future, the authors hope to ...

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New software processes huge amounts of single-cell data

Comprehensive analysis of large gene-expression datasets

13-Feb-2018

Scientists from the Helmholtz Zentrum München have developed a program that is able to help manage enormous datasets. The software, named Scanpy, is a candidate for analyzing the Human Cell Atlas. “It’s about analyzing gene-expression data of a large number of individual cells,” explains lead ...

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Selenium Protects a Specific Type of Interneurons in the Brain

Scientific ‘by-catch‘ solves decades-old mystery

03-Jan-2018

200 years after the discovery of the trace element selenium, researchers at Helmholtz Zentrum München have shown for the first time why this chemical element is indispensable for mammalian life. As integral part of the enzyme GPX4, selenium protects a subset of neurons from cell death during ...

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(Re)-acquiring the potential to become everything

20-Dec-2017

A new study identifies a specific population of pluripotent embryonic stem cells that can reprogram to totipotent-like cells in culture. Moreover, the scientists of Helmholtz Zentrum München and Ludwig-Maximilians-Universität München (LMU) have identified bottlenecks and drivers of this ...

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Immune cells help fat deal with environmental challenges

Immunosuppressive regulatory T-cells play an important role in the functioning of adipose tissue

12-Sep-2017

The number of obese people as well as those suffering from type 2 diabetes is increasing worldwide. Both disorders are associated with metabolic changes including amplified inflammatory responses in adipose tissue. “Previous studies have indicated that immunosuppressive regulatory T-cells – or ...

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Repetitive elements shape embryonic chromatin landscape

30-Aug-2017

Retrotransposons are repetitive elements that form almost half of the mammalian genome. Even though they are so common, they have previously been considered to be fairly insignificant. Together with colleagues from the USA, scientists from the Helmholtz Zentrum München have now shown that ...

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Clear view on stem cell development

Image correction software simplifies quantification of stem cells

22-Jun-2017

Today, tracking the development of individual cells and spotting the associated factors under the microscope is nothing unusual. However, impairments like shadows or changes in the background complicate the interpretation of data. Now, researchers at the Technical University of Munich (TUM) and ...

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Nanoparticle Exposure Can Awaken Dormant Viruses

18-Jan-2017

Nanoparticles from combustion engines can activate viruses that are dormant in in lung tissue cells. This is the result of a study by researchers of Helmholtz Zentrum München, a partner in the German Center for Lung Research (DZL). To evade the immune system, some viruses hide in cells of their ...

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Big Data for small cells – a new tracking and quantification tool for single cells

20-Jul-2016

Working with colleagues from the ETH Zürich, scientists at the Helmholtz Zentrum München and the Technical University of Munich have developed software that allows observing cells for weeks while also measuring molecular properties. Certain questions in modern cell biology can only be answered by ...

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