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11 Current news about the topic crispr/cas9

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Moths and magnets could save lives

Experimental therapy could repair mutations that cause genetic diseases

15-Nov-2018

A new technology that relies on a moth-infecting virus and nanomagnets could be used to edit defective genes that give rise to diseases like sickle cell, muscular dystrophy and cystic fibrosis. Rice University bioengineer Gang Bao has combined magnetic nanoparticles with a viral container drawn ...

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Genetic disease healed using genome editing

10-Oct-2018

A team of researchers from ETH Zurich and the University Children’s Hospital Zurich applied a newly developed editing tool to target and correct genetic mutations. By doing so, the researchers healed mice suffering from a genetic metabolic disorder that also affects humans. Parents of newborns ...

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Less failure in CRIPSR gene editing

Biochemists discover cause of genome editing failures

13-Jul-2018

Researchers from the University of Illinois at Chicago are the first to describe why CRISPR gene editing sometimes fails to work, and how the process can be made to be much more efficient. CRISPR is a gene-editing tool that allows scientists to cut out unwanted genes or genetic material from DNA, ...

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CRISPR editing reduces repetitive behavior in mice with a form of autism

28-Jun-2018

Scientists have used CRISPR-Cas9 gene editing to lessen some autism symptoms in mice with a form of fragile X syndrome, the most common known single-gene cause of autism spectrum disorder. Employing gold nanoparticles to deliver the DNA-cutting Cas9 enzyme into the brain - a technique developed ...

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Multifunctional platform for the delivery of gene therapeutics

Thermo-triggered release of a genome-editing machinery by modified gold nanoparticles

24-Jan-2018

Gene editing is one of the hottest topics in cancer research. A Chinese research team has now developed a gold-nanoparticle-based multifunctional vehicle to transport the “gene scissors” to the tumor cell genome. As the authors report, their nonviral transport and release platform of gene-editing ...

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Searching for the CRISPR Swiss-army knife

13-Dec-2017

Scientists at the University of Copenhagen, led by the Spanish Professor Guillermo Montoya, are investigating the molecular features of different molecular scissors of the CRISPR-Cas system to shed light on the so-called 'Swiss-army knives' of genome editing. Montoya's research group has ...

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Making mosquitoes self-destruct

16-Nov-2017

Researchers at the University of California, Riverside have developed transgenic mosquitoes that stably express the Cas9 enzyme in their germline. The addition of Cas9 will enable the use of the CRISPR gene editing tool to make efficient, targeted changes to the mosquitoes' DNA. As proof of ...

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Circular RNA linked to brain function

16-Aug-2017

For the first time, scientists have shown that circular RNA is linked to brain function. When a RNA molecule called Cdr1as was deleted from the genome of mice, the animals had problems filtering out unnecessary information – like patients suffering from neuropsychiatric disorders. While hundreds ...

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CRISPR gene editing can cause hundreds of unintended mutations

31-May-2017

As CRISPR-Cas9 starts to move into clinical trials, a new study published in Nature Methods has found that the gene-editing technology can introduce hundreds of unintended mutations into the genome. "We feel it's critical that the scientific community consider the potential hazards of all ...

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Testing the Efficacy of New Gene Therapies More Efficiently

22-Mar-2017

Using a new cellular model, innovative gene therapy approaches for the hereditary immunodeficiency Chronic Granulomatous Disease can be tested more rapidly and more cost-effectively in the lab for their efficacy. A team of researchers from the University of Zurich and the Children’s Hospital ...

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