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15 Current news about the topic crispr

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Liver-on-a-chip, the ideal test environment for CRISPR

16-Oct-2018

Two Arizona State University professors are among the first recipients ofSomatic Cell Genome Editing (SCGE) grants from the National Institutes of Health Common Fund. The $2,600,000, five-year grant will fund the first study of the genome editing technology CRISPR to be used on a "human liver ...

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Genetic disease healed using genome editing

10-Oct-2018

A team of researchers from ETH Zurich and the University Children’s Hospital Zurich applied a newly developed editing tool to target and correct genetic mutations. By doing so, the researchers healed mice suffering from a genetic metabolic disorder that also affects humans. Parents of newborns ...

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Precise, Highly Efficient Gene Repair

Researchers develop new CRISPR/Cas process using Japanese ricefish

31-Aug-2018

The molecular tool CRISPR/Cas allows introducing DNA double strand breaks into any gene of interest consequently resulting in stochastic mutations at the site of the target gene. However, precise gene repair through the application of a rescue construct suffers from limited efficiency. ...

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Better Genome Editing

Method giving complete spatiotemporal control and treads DNA lightly

24-Aug-2018

A major obstacle to in-cell genome editing is, well, the cell itself.“Human cells don’t like to take in stuff,” explained UC Santa Barbara’s Norbert Reich, a professor in the Department of Chemistry and Biochemistry. The human cell has evolved a “trash disposal” mechanism that isolates and breaks ...

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Less failure in CRIPSR gene editing

Biochemists discover cause of genome editing failures

13-Jul-2018

Researchers from the University of Illinois at Chicago are the first to describe why CRISPR gene editing sometimes fails to work, and how the process can be made to be much more efficient. CRISPR is a gene-editing tool that allows scientists to cut out unwanted genes or genetic material from DNA, ...

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The world's tiniest first responders

'Walking molecules' haul away damaged DNA to the cell's emergency room

22-Jun-2018

The cell has its own paramedic team and emergency room to aid and repair damaged DNA, a new USC Dornsife study reveals. The findings are timely, as scientists are delving into the potential of genome editing with the DNA-cutting enzyme, CRISPR-Cas9, to treat diseases or to advance scientific ...

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Understanding how DNA is selectively tagged with 'do not use' marks

09-May-2018

Not all of your genome needs to be active at any given time. Some regions are prone to hopping around the genome in problematic ways if left unchecked; others code for genes that need to be turned off in certain cells or at certain times. One way that cells keep these genetic elements under ...

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Newly discovered CRISPR mechanism may help prevent dangerous errors

Better understanding of how gene editing works may make process safer

02-Mar-2018

Even as CRISPR gene-editing technology is offering insights into genetic diseases, researchers are discovering new things about how it actually works. In the first of two papers just published in the Journal of the American Chemical Society (JACS), researchers at The Ohio State University report ...

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A Pair of RNA Scissors with Many Functions

Arming CRISPR/Cas systems with an enzyme that also controls the translation of genetic information into protein

08-Feb-2018

CRISPR/Cas systems are known as promising “gene scissors” in the genome editing of plants, animals, and microorganisms by targeting specific regions in their DNA – and perhaps they can even be used to correct genetic defects. A team of scientists led by Juliane Behler and Prof. Dr. Wolfgang Hess ...

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Multifunctional platform for the delivery of gene therapeutics

Thermo-triggered release of a genome-editing machinery by modified gold nanoparticles

24-Jan-2018

Gene editing is one of the hottest topics in cancer research. A Chinese research team has now developed a gold-nanoparticle-based multifunctional vehicle to transport the “gene scissors” to the tumor cell genome. As the authors report, their nonviral transport and release platform of gene-editing ...

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