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47 Current news about the topic enzymes

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Optimized Binding Cavity

Directed evolution of a designer enzyme with an unnatural catalytic amino acid

05-Feb-2019

The impressively high conversion rates of natural enzymes partly result from increasing the catalytic activity of a selected few amino acid side chains through precise positioning within the protein binding cavity. Scientists have now demonstrated that such fine-tuning is also possible for ...

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An errant editing enzyme promotes tumor suppressor loss and leukemia propagation

08-Jan-2019

Researchers at University of California San Diego School of Medicine report that detection of "copy editing" by a stem cell enzyme called ADAR1, which is active in more than 20 tumor types, may provide a kind of molecular radar for early detection of malignancies and represent a new therapeutic ...

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How a small molecule promotes removal of excess cholesterol

28-Nov-2018

Scientists have determined the structure of the activated form of an enzyme that helps to return excess cholesterol to the liver. The research reveals how a drug-like chemical stimulates the action of the lecithin:cholesterol acyltransferase (LCAT) enzyme. It also suggests that future drugs using ...

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Next step on the path towards an efficient biofuel cell

Two concepts combined making system as efficient as precious metal catalysts

16-Nov-2018

Fuel cells that work with the enzyme hydrogenase are, in principle, just as efficient as those that contain the expensive precious metal platinum as a catalyst. However, the enzymes need an aqueous environment, which makes it difficult for the starting material for the reaction – hydrogen – to ...

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Moths and magnets could save lives

Experimental therapy could repair mutations that cause genetic diseases

15-Nov-2018

A new technology that relies on a moth-infecting virus and nanomagnets could be used to edit defective genes that give rise to diseases like sickle cell, muscular dystrophy and cystic fibrosis. Rice University bioengineer Gang Bao has combined magnetic nanoparticles with a viral container drawn ...

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Pathogens may evade immune response with metal-free enzyme required for DNA replication

23-Oct-2018

Some bacterial pathogens, including those that cause strep throat and pneumonia, are able to create the components necessary to replicate their DNA without the usually required metal ions. This process may allow infectious bacteria to replicate even when the host's immune system sequesters iron ...

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Genetic disease healed using genome editing

10-Oct-2018

A team of researchers from ETH Zurich and the University Children’s Hospital Zurich applied a newly developed editing tool to target and correct genetic mutations. By doing so, the researchers healed mice suffering from a genetic metabolic disorder that also affects humans. Parents of newborns ...

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First experiments at Europe's new X-ray laser reveal unknown structure of antibiotics killer

DESY-led international collaboration obtains first scientific results from European XFEL

05-Oct-2018

An international collaboration led by DESY and consisting of over 120 researchers has announced the results of the first scientific experiments at Europe's new X-ray laser European XFEL. The pioneering work not only demonstrates that the new research facility can speed up experiments by more than ...

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Making better use of enzymes

New research project at Jacobs University

20-Sep-2018

In biocatalysis, enzymes are used to accelerate chemical reactions. This plays a role in many areas, such as the production of beer, wine and cheese or the pharmaceutical industry. A research project at the English-medium Jacobs University led by Marcelo Fernandez-Lahore, Professor of Biochemical ...

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Newly discovered enzyme is 'firing pin' for plant immunity

19-Sep-2018

Just like humans, plants have an immune system that helps them fight off infections. Plant immunity has some important differences: they don't make antibodies and can't fight off the same bug more quickly months or years later. However, plant cells can identify pathogens and react to them, often ...

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