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10 Current news about the topic gene expression

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A new way to stimulate cellular recycling process

18-May-2018

Brown University researchers studying the biology of aging have demonstrated a new strategy for stimulating autophagy, the process by which cells rebuild themselves by recycling their own worn-out parts. In a study the researchers show that the approach increased the lifespans of worms and flies, ...

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Scientists characterise cancer genes using ground-breaking new method

09-Apr-2018

In a paper in the journal “Science”, researchers from the Vienna BioCenter combine cutting-edge technologies to decipher regulatory functions of important cancer genes. Key to this success is an innovative method called “SLAMseq”, which allows the direct detection of sudden changes in gene ...

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Cells communicate in a dynamic code

Important intercellular communication encodes and transmits more than thought

20-Feb-2018

Multicellular organisms like ourselves depend on a constant flow of information between cells, coordinating their activities in order to proliferate and differentiate. Deciphering the language of intercellular communication has long been a central challenge in biology. Now, Caltech scientists ...

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New software processes huge amounts of single-cell data

Comprehensive analysis of large gene-expression datasets

13-Feb-2018

Scientists from the Helmholtz Zentrum München have developed a program that is able to help manage enormous datasets. The software, named Scanpy, is a candidate for analyzing the Human Cell Atlas. “It’s about analyzing gene-expression data of a large number of individual cells,” explains lead ...

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A Pair of RNA Scissors with Many Functions

Arming CRISPR/Cas systems with an enzyme that also controls the translation of genetic information into protein

08-Feb-2018

CRISPR/Cas systems are known as promising “gene scissors” in the genome editing of plants, animals, and microorganisms by targeting specific regions in their DNA – and perhaps they can even be used to correct genetic defects. A team of scientists led by Juliane Behler and Prof. Dr. Wolfgang Hess ...

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'Mysterious' non-protein-coding RNAs play important roles in gene expression

16-Jan-2017

In cells, DNA is transcribed into RNAs that provide the molecular recipe for cells to make proteins. Most of the genome is transcribed into RNA, but only a small proportion of RNAs are actually from the protein-coding regions of the genome. "Why are the non-coding regions transcribed at all? ...

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Stress bypasses quality control

Researchers find cellular mechanism to stop quality control of gene expression

15-Dec-2016

Under stressful life conditions many proteins lose their functionality. A natural mechanism that can be found in all cells leads to the preferred synthesis of stabilizing proteins (so called chaperones), which protect cells from stress and the subsequent “destruction” of normal proteins. ...

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Controlling cell-fate decisions

26-Sep-2016

Rafal Ciosk and his group at the FMI have identified an important link between the Notch signaling pathway and PRC2-mediated gene silencing. They showed that a fine balance between epigenetic silencing and signaling is crucial for cell-fate decisions. While this study has important implications ...

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DNA dominos on a chip

Carriers of genetic information packed together on a biochip like in nature

11-Aug-2016

Normally, individual molecules of genetic material repel each other. However, when space is limited DNA molecules must be packed together more tightly. This case arises in sperm, cell nuclei and the protein shells of viruses. An international team of physicists has now succeeded in artificially ...

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Watching 'jumping genes' in action

Real-time observation of transposon activity in living cells

16-Jun-2016

"Jumping genes" are ubiquitous. Every domain of life hosts these sequences of DNA that can "jump" from one position to another along a chromosome; in fact, nearly half the human genome is made up of jumping genes. Depending on their specific excision and insertion points, jumping genes can ...

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