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11 Current news about the topic gene expression
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Machine-learning driven findings uncover new cellular players in tumor microenvironment
Involvement of adipocytes in nivolumab response in ipilimumab resistant melanoma patients
18-Oct-2018
New findings presented by CytoReason reveals possible new cellular players in the tumor microenvironment that could impact the treatment process for the most in-need patients - those who have already failed to respond to ipilimumab (anti-CTLA4) immunotherapy. Once validated, the findings could ...
A new way to stimulate cellular recycling process
18-May-2018
Brown University researchers studying the biology of aging have demonstrated a new strategy for stimulating autophagy, the process by which cells rebuild themselves by recycling their own worn-out parts. In a study the researchers show that the approach increased the lifespans of worms and flies, ...
Scientists characterise cancer genes using ground-breaking new method
09-Apr-2018
In a paper in the journal “Science”, researchers from the Vienna BioCenter combine cutting-edge technologies to decipher regulatory functions of important cancer genes. Key to this success is an innovative method called “SLAMseq”, which allows the direct detection of sudden changes in gene ...
Cells communicate in a dynamic code
Important intercellular communication encodes and transmits more than thought
20-Feb-2018
Multicellular organisms like ourselves depend on a constant flow of information between cells, coordinating their activities in order to proliferate and differentiate. Deciphering the language of intercellular communication has long been a central challenge in biology. Now, Caltech scientists ...
New software processes huge amounts of single-cell data
Comprehensive analysis of large gene-expression datasets
13-Feb-2018
Scientists from the Helmholtz Zentrum München have developed a program that is able to help manage enormous datasets. The software, named Scanpy, is a candidate for analyzing the Human Cell Atlas. “It’s about analyzing gene-expression data of a large number of individual cells,” explains lead ...
A Pair of RNA Scissors with Many Functions
Arming CRISPR/Cas systems with an enzyme that also controls the translation of genetic information into protein
08-Feb-2018
CRISPR/Cas systems are known as promising “gene scissors” in the genome editing of plants, animals, and microorganisms by targeting specific regions in their DNA – and perhaps they can even be used to correct genetic defects. A team of scientists led by Juliane Behler and Prof. Dr. Wolfgang Hess ...
'Mysterious' non-protein-coding RNAs play important roles in gene expression
16-Jan-2017
In cells, DNA is transcribed into RNAs that provide the molecular recipe for cells to make proteins. Most of the genome is transcribed into RNA, but only a small proportion of RNAs are actually from the protein-coding regions of the genome. "Why are the non-coding regions transcribed at all? ...
Stress bypasses quality control
Researchers find cellular mechanism to stop quality control of gene expression
15-Dec-2016
Under stressful life conditions many proteins lose their functionality. A natural mechanism that can be found in all cells leads to the preferred synthesis of stabilizing proteins (so called chaperones), which protect cells from stress and the subsequent “destruction” of normal proteins. ...
Controlling cell-fate decisions
26-Sep-2016
Rafal Ciosk and his group at the FMI have identified an important link between the Notch signaling pathway and PRC2-mediated gene silencing. They showed that a fine balance between epigenetic silencing and signaling is crucial for cell-fate decisions. While this study has important implications ...
DNA dominos on a chip
Carriers of genetic information packed together on a biochip like in nature
11-Aug-2016
Normally, individual molecules of genetic material repel each other. However, when space is limited DNA molecules must be packed together more tightly. This case arises in sperm, cell nuclei and the protein shells of viruses. An international team of physicists has now succeeded in artificially ...
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