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13 Current news about the topic rna

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A Pair of RNA Scissors with Many Functions

Arming CRISPR/Cas systems with an enzyme that also controls the translation of genetic information into protein

08-Feb-2018

CRISPR/Cas systems are known as promising “gene scissors” in the genome editing of plants, animals, and microorganisms by targeting specific regions in their DNA – and perhaps they can even be used to correct genetic defects. A team of scientists led by Juliane Behler and Prof. Dr. Wolfgang Hess ...

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Multifunctional platform for the delivery of gene therapeutics

Thermo-triggered release of a genome-editing machinery by modified gold nanoparticles

24-Jan-2018

Gene editing is one of the hottest topics in cancer research. A Chinese research team has now developed a gold-nanoparticle-based multifunctional vehicle to transport the “gene scissors” to the tumor cell genome. As the authors report, their nonviral transport and release platform of gene-editing ...

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Spaghetti-like, DNA 'noodle origami' the new shape of things to come for nanotechnology

18-Dec-2017

For the past few decades, scientists have been inspired by the blueprint of life, DNA, as the shape of things to come for nanotechnology. This burgeoning field is called DNA origami. Scientist borrowed its moniker from the paper artists who conjure up birds, flowers and planes from imaginatively ...

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Potential 'missing link' in chemistry that led to life on earth found

08-Nov-2017

Chemists at The Scripps Research Institute (TSRI) have found a compound that may have been a crucial factor in the origins of life on Earth. Origins-of-life researchers have hypothesized that a chemical reaction called phosphorylation may have been crucial for the assembly of three key ...

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Circular RNA linked to brain function

16-Aug-2017

For the first time, scientists have shown that circular RNA is linked to brain function. When a RNA molecule called Cdr1as was deleted from the genome of mice, the animals had problems filtering out unnecessary information – like patients suffering from neuropsychiatric disorders. While hundreds ...

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Cut the long story short – and stitch it back together

22-Mar-2017

A species of unicellular ciliate has found a special trick to make use of the cellular machinery in seemingly impossible ways. Researchers of the NCCR «RNA & Disease – The Role of RNA Biology in Disease Mechanisms» of the University of Bern have for the first time described a mechanism in detail ...

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Researchers Imitate Molecular Crowding in Cells

02-Mar-2017

Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to simulate these confined natural conditions in artificial vesicles for the first time. The results are offering better insight into the ...

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Quality control inside the cell

How rescue proteins dispose of harmful messages

23-Jan-2017

The ability to dispose of proteins that are either aberrant or (in the worst case) toxic is fundamental to a cell's survival. Researchers from Charité - Universitätsmedizin Berlin have been able to demonstrate the manner in which two specific proteins recognize defective messenger RNAs (molecules ...

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'Mysterious' non-protein-coding RNAs play important roles in gene expression

16-Jan-2017

In cells, DNA is transcribed into RNAs that provide the molecular recipe for cells to make proteins. Most of the genome is transcribed into RNA, but only a small proportion of RNAs are actually from the protein-coding regions of the genome. "Why are the non-coding regions transcribed at all? ...

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Stress bypasses quality control

Researchers find cellular mechanism to stop quality control of gene expression

15-Dec-2016

Under stressful life conditions many proteins lose their functionality. A natural mechanism that can be found in all cells leads to the preferred synthesis of stabilizing proteins (so called chaperones), which protect cells from stress and the subsequent “destruction” of normal proteins. ...

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