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10 Current news about the topic rna

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Potential 'missing link' in chemistry that led to life on earth found

08-Nov-2017

Chemists at The Scripps Research Institute (TSRI) have found a compound that may have been a crucial factor in the origins of life on Earth. Origins-of-life researchers have hypothesized that a chemical reaction called phosphorylation may have been crucial for the assembly of three key ...

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Circular RNA linked to brain function

16-Aug-2017

For the first time, scientists have shown that circular RNA is linked to brain function. When a RNA molecule called Cdr1as was deleted from the genome of mice, the animals had problems filtering out unnecessary information – like patients suffering from neuropsychiatric disorders. While hundreds ...

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Cut the long story short – and stitch it back together

22-Mar-2017

A species of unicellular ciliate has found a special trick to make use of the cellular machinery in seemingly impossible ways. Researchers of the NCCR «RNA & Disease – The Role of RNA Biology in Disease Mechanisms» of the University of Bern have for the first time described a mechanism in detail ...

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Researchers Imitate Molecular Crowding in Cells

02-Mar-2017

Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to simulate these confined natural conditions in artificial vesicles for the first time. The results are offering better insight into the ...

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Quality control inside the cell

How rescue proteins dispose of harmful messages

23-Jan-2017

The ability to dispose of proteins that are either aberrant or (in the worst case) toxic is fundamental to a cell's survival. Researchers from Charité - Universitätsmedizin Berlin have been able to demonstrate the manner in which two specific proteins recognize defective messenger RNAs (molecules ...

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'Mysterious' non-protein-coding RNAs play important roles in gene expression

16-Jan-2017

In cells, DNA is transcribed into RNAs that provide the molecular recipe for cells to make proteins. Most of the genome is transcribed into RNA, but only a small proportion of RNAs are actually from the protein-coding regions of the genome. "Why are the non-coding regions transcribed at all? ...

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Stress bypasses quality control

Researchers find cellular mechanism to stop quality control of gene expression

15-Dec-2016

Under stressful life conditions many proteins lose their functionality. A natural mechanism that can be found in all cells leads to the preferred synthesis of stabilizing proteins (so called chaperones), which protect cells from stress and the subsequent “destruction” of normal proteins. ...

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Controlling cell-fate decisions

26-Sep-2016

Rafal Ciosk and his group at the FMI have identified an important link between the Notch signaling pathway and PRC2-mediated gene silencing. They showed that a fine balance between epigenetic silencing and signaling is crucial for cell-fate decisions. While this study has important implications ...

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Seeing RNA at the nanoscale

06-Jul-2016

Cells contain thousands of messenger RNA molecules, which carry copies of DNA's genetic instructions to the rest of the cell. MIT engineers have now developed a way to visualize these molecules in higher resolution than previously possible in intact tissues, allowing researchers to precisely map ...

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In a role reversal, RNAs proofread themselves

Molecular photographs of an enzyme bound to RNA reveal a new, inherent quality control mechanism

02-Feb-2015

Building a protein is a lot like a game of telephone: information is passed along from one messenger to another, creating the potential for errors every step of the way. There are separate, specialized enzymatic machines that proofread at each step, ensuring that the instructions encoded in our ...

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