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29 Current news about the topic rna

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Turbocharger for the cell machinery

14-Jan-2019

The classic molecular-biological narrative has a simple form: Gene-RNA-protein. This is what we learned in school: DNA is transcribed into RNA. In the protein factories (the so-called ribosomes), the RNA serves as a kind of punch card - the proteins are assembled by the machinery exactly ...

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An errant editing enzyme promotes tumor suppressor loss and leukemia propagation

08-Jan-2019

Researchers at University of California San Diego School of Medicine report that detection of "copy editing" by a stem cell enzyme called ADAR1, which is active in more than 20 tumor types, may provide a kind of molecular radar for early detection of malignancies and represent a new therapeutic ...

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New Ways to Look at Protein-RNA Networks

10-Dec-2018

For their vital tasks, all RNA molecules in our cells require proteins as binding partners. Scientists at the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) and colleagues from the European Molecular Biology Laboratory (EMBL) have developed the first method with which they ...

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RNA Microchips

A new chapter in ribonucleic acid synthesis

08-Nov-2018

Ribonucleic acid (RNA) is, along with DNA and protein, one of the three primary biological macromolecules and was probably the first to arise in early life forms. In the “RNA world” hypothesis, RNA is able to support life on its own because it can both store information and catalyze biochemical ...

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Pathogens may evade immune response with metal-free enzyme required for DNA replication

23-Oct-2018

Some bacterial pathogens, including those that cause strep throat and pneumonia, are able to create the components necessary to replicate their DNA without the usually required metal ions. This process may allow infectious bacteria to replicate even when the host's immune system sequesters iron ...

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Green tea compound helps siRNA slip inside cells

24-Sep-2018

Drinking green tea has been linked to health benefits ranging from cardiovascular disease prevention to weight loss. Although many of these claims still need to be verified in the clinic, an antioxidant in green tea called epigallocatechin gallate (EGCG) appears to have beneficial effects in ...

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Precise, Highly Efficient Gene Repair

Researchers develop new CRISPR/Cas process using Japanese ricefish

31-Aug-2018

The molecular tool CRISPR/Cas allows introducing DNA double strand breaks into any gene of interest consequently resulting in stochastic mutations at the site of the target gene. However, precise gene repair through the application of a rescue construct suffers from limited efficiency. ...

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Creating a family tree for each body cell in real time

Evolving genetic barcodes show origin of cells in vivo

13-Aug-2018

All humans begin life as a single cell that divides repeatedly to form two, then four, then eight cells, all the way up to the ~26 billion cells that make up a newborn. Tracing how and when those 26 billion cells arise from one zygote is the grand challenge of developmental biology, a field that ...

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Less failure in CRIPSR gene editing

Biochemists discover cause of genome editing failures

13-Jul-2018

Researchers from the University of Illinois at Chicago are the first to describe why CRISPR gene editing sometimes fails to work, and how the process can be made to be much more efficient. CRISPR is a gene-editing tool that allows scientists to cut out unwanted genes or genetic material from DNA, ...

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New insight into the maturation of miRNAs

04-Jul-2018

An international research team led by Helmholtz Zentrum München, Technical University of Munich and the University of Edinburgh has used an integrated structural biological approach to elucidate the maturation of a cancer-causing microRNA in gene regulation. In the future, the authors hope to ...

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