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21 Current news about the topic rna

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Less failure in CRIPSR gene editing

Biochemists discover cause of genome editing failures

13-Jul-2018

Researchers from the University of Illinois at Chicago are the first to describe why CRISPR gene editing sometimes fails to work, and how the process can be made to be much more efficient. CRISPR is a gene-editing tool that allows scientists to cut out unwanted genes or genetic material from DNA, ...

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New insight into the maturation of miRNAs

04-Jul-2018

An international research team led by Helmholtz Zentrum München, Technical University of Munich and the University of Edinburgh has used an integrated structural biological approach to elucidate the maturation of a cancer-causing microRNA in gene regulation. In the future, the authors hope to ...

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Contaminated lab kits

Scientific sleuthing for reproducible results

14-Jun-2018

Researchers found traces of foreign, non-human genetic material in human blood samples. It turned out that it was not a groundbreaking scientific discovery, but mostly the result of contaminated laboratory materials. Scientists led by Associate Prof. Paul Wilmes of the Luxembourg Centre for ...

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In the beginning was the phase separation

Was a simple mechanism decisive for the origin of life?

25-May-2018

The question of the origin of life remains one of the oldest unanswered scientific questions. A team at the Technical University of Munich (TUM) has now shown for the first time that phase separation is an extremely efficient way of controlling the selection of chemical building blocks and ...

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Understanding how DNA is selectively tagged with 'do not use' marks

09-May-2018

Not all of your genome needs to be active at any given time. Some regions are prone to hopping around the genome in problematic ways if left unchecked; others code for genes that need to be turned off in certain cells or at certain times. One way that cells keep these genetic elements under ...

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Who am I? How cells find their identity

02-May-2018

The research group of Alex Schier, Director of the Biozentrum, University of Basel, has investigated more closely how a single embryonic cell develops into a heart, nerve or blood cell. For the first time, the researchers have been able to reconstruct the developmental trajectories of individual ...

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Scientists characterise cancer genes using ground-breaking new method

09-Apr-2018

In a paper in the journal “Science”, researchers from the Vienna BioCenter combine cutting-edge technologies to decipher regulatory functions of important cancer genes. Key to this success is an innovative method called “SLAMseq”, which allows the direct detection of sudden changes in gene ...

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A protein that self-replicates

01-Mar-2018

Long regarded as a biological aberration, amyloids are fibrous aggregates of short protein fragments. Amyloids have a bad reputation because they are thought to be the cause of multiple neurodegenerative diseases, including Alzheimer's, Parkinson's and Creutzfeldt-Jakob disease. It was only ...

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A Pair of RNA Scissors with Many Functions

Arming CRISPR/Cas systems with an enzyme that also controls the translation of genetic information into protein

08-Feb-2018

CRISPR/Cas systems are known as promising “gene scissors” in the genome editing of plants, animals, and microorganisms by targeting specific regions in their DNA – and perhaps they can even be used to correct genetic defects. A team of scientists led by Juliane Behler and Prof. Dr. Wolfgang Hess ...

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Multifunctional platform for the delivery of gene therapeutics

Thermo-triggered release of a genome-editing machinery by modified gold nanoparticles

24-Jan-2018

Gene editing is one of the hottest topics in cancer research. A Chinese research team has now developed a gold-nanoparticle-based multifunctional vehicle to transport the “gene scissors” to the tumor cell genome. As the authors report, their nonviral transport and release platform of gene-editing ...

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