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26 Current news about the topic rna

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RNA Microchips

A new chapter in ribonucleic acid synthesis

08-Nov-2018

Ribonucleic acid (RNA) is, along with DNA and protein, one of the three primary biological macromolecules and was probably the first to arise in early life forms. In the “RNA world” hypothesis, RNA is able to support life on its own because it can both store information and catalyze biochemical ...

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Pathogens may evade immune response with metal-free enzyme required for DNA replication

23-Oct-2018

Some bacterial pathogens, including those that cause strep throat and pneumonia, are able to create the components necessary to replicate their DNA without the usually required metal ions. This process may allow infectious bacteria to replicate even when the host's immune system sequesters iron ...

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Green tea compound helps siRNA slip inside cells

24-Sep-2018

Drinking green tea has been linked to health benefits ranging from cardiovascular disease prevention to weight loss. Although many of these claims still need to be verified in the clinic, an antioxidant in green tea called epigallocatechin gallate (EGCG) appears to have beneficial effects in ...

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Precise, Highly Efficient Gene Repair

Researchers develop new CRISPR/Cas process using Japanese ricefish

31-Aug-2018

The molecular tool CRISPR/Cas allows introducing DNA double strand breaks into any gene of interest consequently resulting in stochastic mutations at the site of the target gene. However, precise gene repair through the application of a rescue construct suffers from limited efficiency. ...

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Creating a family tree for each body cell in real time

Evolving genetic barcodes show origin of cells in vivo

13-Aug-2018

All humans begin life as a single cell that divides repeatedly to form two, then four, then eight cells, all the way up to the ~26 billion cells that make up a newborn. Tracing how and when those 26 billion cells arise from one zygote is the grand challenge of developmental biology, a field that ...

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Less failure in CRIPSR gene editing

Biochemists discover cause of genome editing failures

13-Jul-2018

Researchers from the University of Illinois at Chicago are the first to describe why CRISPR gene editing sometimes fails to work, and how the process can be made to be much more efficient. CRISPR is a gene-editing tool that allows scientists to cut out unwanted genes or genetic material from DNA, ...

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New insight into the maturation of miRNAs

04-Jul-2018

An international research team led by Helmholtz Zentrum München, Technical University of Munich and the University of Edinburgh has used an integrated structural biological approach to elucidate the maturation of a cancer-causing microRNA in gene regulation. In the future, the authors hope to ...

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Contaminated lab kits

Scientific sleuthing for reproducible results

14-Jun-2018

Researchers found traces of foreign, non-human genetic material in human blood samples. It turned out that it was not a groundbreaking scientific discovery, but mostly the result of contaminated laboratory materials. Scientists led by Associate Prof. Paul Wilmes of the Luxembourg Centre for ...

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In the beginning was the phase separation

Was a simple mechanism decisive for the origin of life?

25-May-2018

The question of the origin of life remains one of the oldest unanswered scientific questions. A team at the Technical University of Munich (TUM) has now shown for the first time that phase separation is an extremely efficient way of controlling the selection of chemical building blocks and ...

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Understanding how DNA is selectively tagged with 'do not use' marks

09-May-2018

Not all of your genome needs to be active at any given time. Some regions are prone to hopping around the genome in problematic ways if left unchecked; others code for genes that need to be turned off in certain cells or at certain times. One way that cells keep these genetic elements under ...

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