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From the reveller to the lark

The internal clock changes with age

Because of their genes, some people come into the world either as a lark (early riser) or a night-owl (late sleeper). In addition, however, even in normal people, such ”chronotype“ changes with age. Starting at puberty they develop into revellers. At the age of 20 a change occurs and the ...

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The Benefits of Gravimetric Sample Preparation

Improving the Efficiency and Quality of Analytical Workflows

Analytical sample and standard preparation in a pharmaceutical or QA/QC laboratory is typically a manual procedure that requires that solids be weighed and diluted to the mark volumetrically. A minimum of 50 ml of solution is usually prepared for analytical measurements, even though the amount ...

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A Complex Mixture

Automated MOSH/MOAH determination with the aid of coupled LC-GC

Once only of academic interest, the combination of liquid chromatographic separation with subsequent separation in the gas-phase is proving to be suitable for routine use. In routine laboratory work, the method continues to present a major challenge, above all with regard to precision, ...

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With Light in the Fight against Malaria

Efficient synthesis of an anti-malarial agent in a continuous-flow microreactor

Malaria represents a global threat to health, which is difficult to keep under control. Amongst more than 200 million sufferers, over 500,000 die each year of the disease, with the risk of a fatal outcome being particularly high in children [1].

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Open Innovation

University and commerce – a winning partnership

University research is predominantly orientated towards the development of new scientific findings. But it is also an important element in the training and further education of ­up-and-coming scientific talent. In principle, the central focus is the generation of scientific results that yield ...

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Interesting Health Promoters

The in vivo-metabolism of flavonoids: a challenge for analytics and pharmacology

There is barely a class of compounds among the secondary metabolites of plants that is so prominently represented in our lives as that of the flavonoids. They are found in ­numerous food substances in various oxidation states, and principally as glycosides (Fig. 1). By consuming fruit, vegetables ...

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The Beginning of the End?

Or The End of the Beginning?

Those of us who have been either directly involved in, or on the periphery of, the pharmaceutical industry over the last decade have seen at first hand a dramatic change. Times change, and technology changes. Take computer data storage for example. Not so long ago, the floppy disk was state of ...

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DIN/ISO Compliant Calibrations

Essential performance characteristics in instrumental analysis

Today Analytical Chemistry is embedded in a strictly regulated environment and it has to be ensured that verifiable and officially authorised methods are used. How can this be achieved in a reproducible and unequivocal way? Here we approach this question with respect to the problem of ...

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Potential for Success

Reduce energy costs efficiently in the pharmaceutical industry

The increase in energy efficiency is developing across all sectors into one of the industry‘s most important competition factors. Most recently, this development has been further strengthened by increasing energy prices, environmental impacts and political demands.

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Holistic View

Practical application of GMP analysis of pharmaceutical active ingredients and drugs

Today, the guidelines of „Good Manufacturing Practice“ (GMP) are the basis for any production and marketing of active pharmaceutical ingredients (APIs) and drugs. Comprehensive quality management systems document and control the production processes and environment and not least the analytical ...

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q&more – the networking platform for quality excellence in lab and process

The q&more concept is to increase the visibility of recent research and innovative solutions, and support the exchange of knowledge. In the broad spectrum of subjects covered, the focus is on achieving maximum quality in highly innovative sectors. As a modern knowledge platform, q&more offers market participants one-of-a-kind networking opportunities. Cutting-edge research is presented by authors of international repute. Attractively presented in a high-quality context, and published in German and English, the original articles introduce new concepts and highlight unconventional solution strategies.

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