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What Are We Eating?

Food quality analysis using NMR

What ends up on our plates? We used to think we knew – until we were disabused of this notion in early 2013. Instead of beef, there had been large-scale use of processed horsemeat, especially in frozen products and mincemeat. Although this posed no hazard to health, the damage was enormous, since ...

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Putting Pressure on Pharmaceuticals

Supercritical fluids as a (literal) solution for formulation platforms

As a general rule, the pharmaceuticals industry develops new drugs by applying a complex procedure of formulation utilising excipients suitable for the final drug dosage form. Such development processes are carried out by the companies’ technical departments and in many cases result in solutions ...

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New Trends in Computer-Aided Drug Design

On-line Integration of Super-Computers

Computer-Aided Drug design (CADD) is not new. The Journal of Computer-Aided Molecular Design (Springer) was founded in 1987, when computers in the worldwide top 500 were slower than today’s smart phones. This makes the field a quarter of a century old. Generally, scientific disciplines of this ...

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Expressive

Bacterial surface display for the ­identification of active ingredients for the pharmaceutical and cosmetics industry

Coupling biological molecules to surfaces, and using them in this form for measurement procedures, for analysis and in production processes, is a novel approach that is gaining increasing importance in industrial applications. Using established procedures, surfaces and biological molecules are ...

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A Light for Time, and a Time for Light

Light as a clock: retinal cell significance and function

As everybody knows, our eyes are the sensory organs that allow us to see the world around us. Light enters the eye through the pupil and strikes the photosensitive retina at the back to commence a complex biochemical and physiological process that we know as vision. This ability is vital to ...

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Perfect Coordination

Safe handling of highly potent active ingredients in chemistry

New drugs are developed, among other reasons, with the aim of reducing dosage and having more targeted active ingredients. For patients, this development is definitely beneficial. These ingredients are described as highly potent active ingredients. But what does highly potent mean? And how are ...

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From RNA World to Protein World

RNase P – a possible antibiotics target?

Within the various domains of life, the evolution of the tRNA processing enzyme (RNase P) has led to a set of highly diverse architectonic solutions. Bacterial RNase P thus has a fundamentally different structure to human RNase P enzymes in the cell nucleus and mitochondria. This structural and ...

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The Third Dimension

Protein analysis using multidimensional liquid chromatography with monolithic phases and mass spectrometry

Proteins play a fundamental role in our day-to-day lives. Thanks to proteins we can speak, move about and think; they protect us from disease and repair damage to our bodies. Proteins are also becoming more popular as active pharmaceutical ingredients: in 2012, the market share of ...

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Keeping the Workflow in Focus

Practical implementation of a gravimetric approach to sample preparation

There has been much discussion surrounding the benefits of gravimetric sample preparation during the last 12 months . It has been recognised by industry organisations such as the United States Pharmacopeia (USP) who proposed an update to sub-chapter “Weighing on an Analytical Balance” in ...

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q&more – the networking platform for quality excellence in lab and process

The q&more concept is to increase the visibility of recent research and innovative solutions, and support the exchange of knowledge. In the broad spectrum of subjects covered, the focus is on achieving maximum quality in highly innovative sectors. As a modern knowledge platform, q&more offers market participants one-of-a-kind networking opportunities. Cutting-edge research is presented by authors of international repute. Attractively presented in a high-quality context, and published in German and English, the original articles introduce new concepts and highlight unconventional solution strategies.

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