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Universität Zürich, Institut für Pharmakologie und Toxikologie
Steven B. Brown studied biochemistry at Harvard College, Cambridge, Massachusetts, USA. In 1997 he received his doctorate in the Department of Biological Chemistry and Molecular Pharmacology, Harvard University, Cambridge, Massachusetts, USA. From 1998 – 2005 he was a postdoctoral fellow at the Institute of Molecular Biology at the University of Geneva in the laboratory of Prof. Ueli Schibler, and began his active work on circadian rhythms (Research Project: The identification of proteins and signalling mechanisms involved in the regulation of mammalian circadian rhythms). In 2006, as a Humboldt Fellow at the Charité in Berlin (Prof. Achim Kramer), he researched the topic “Molecular mechanisms regulating chronotype”. Since September 2006 he is Professor of Pharmacology and Toxicology at the Medical Faculty of the University of Zurich.
Because of their genes, some people come into the world either as a lark (early riser) or a night-owl (late sleeper). In addition, however, even in normal people, such ”chronotype“ (…)
Mechanism for DNA Invasion of Adenoviral Covid-19 Vaccines Discovered
Adenoviruses have a linchpin protein that stabilizes their DNA until it reaches the infected cell’s nucleus. The protein then detaches from the viral genome, and the virus uncoats. Only then are the genes released into the nucleus, which is necessary for the production of new viruses. This ... more
Microscopy Deep Learning Predicts Viral Infections
When viruses infect cells, changes in the cell nucleus occur, and these can be observed through fluorescence microscopy. Using fluoresence images from live cells, researchers at the University of Zurich have trained an artificial neural network to reliably recognize cells that are infected ... more
Lipid Metabolism Controls Brain Development
A lipid metabolism enzyme controls brain stem cell activity and lifelong brain development. If the enzyme does not work correctly, it causes learning and memory deficits in humans and mice, as researchers at the University of Zurich have discovered. Regulating stem cell activity via lipid m ... more
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