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Johann Wolfgang Goethe-Universität Frankfurt (Main), Pharmazentrum Frankfurt, Institut für Allgemeine Pharmakologie und Toxikologie
Heinfried H. Radeke studied medicine at the Hannover Medical School (MHH) and received his medical license in 1985. His Ph.D. thesis was recognized as the best research dissertation of 1986. After two years as an assistant physician at the Göttingen University Hospital, he began his career at MHH in 1987 with his research focus: the mechanisms of chronic inflammation in the field of molecular pharmacology. He completed his habilitation in this field in 1993 before further specializing as a consultant for general pharmacology and toxicology, consultant immunologist (DGfI), and consultant for clinical pharmacology (Frankfurt, 2004).
Following a four-month research project at BASF Bioresearch in Cambridge (Boston) in 1992, Heinfried Radeke spent the period 1994–1997 completing further DFG-sponsored research in the USA. This involved one year at UC San Francisco (interleukin-1 alpha and carcinogenesis), followed by two years at Case Western Reserve University in Cleveland (nephritis, differentiation of T cells). Since 2001, Prof. Radeke has been aiding the realignment of pharmazentrum frankfurt (Prof. Josef M. Pfeilschifter, dean of medical faculty and director of the Institute of General Pharmacology and Toxicology) towards immunopharmacology, from 2001 to 2008 as the Dr. Hans Schleussner Foundation Lecturer for Immunopharmacology. He plays a decisive role in the training of medical and dental students, with past positions including that of deputy director of the DFG’s largest research training group, GRK1172 Biologicals, in which over 100 doctorates were awarded from 2005 – 2014.
There are currently several very good reasons to take a closer look at biopharmaceuticals. After the introduction of „modern biologicals“ at the beginning of the 1990s, including (…)
Construction kit for custom-designed products
Microorganisms often assemble natural products similar to product assembly lines. Certain enzymes, non-ribosomal peptide synthetases (NRPS), play a key role in this process. Biotechnologists at Goethe University have now succeeded in changing these enzymes so that entirely new natural produ ... more
Inert Nitrogen Forced to React with Itself
Direct coupling of two molecules of nitrogen: chemists from Würzburg and Frankfurt have achieved what was thought to be impossible. This new reaction is reported in Science magazine and opens new possibilities for one of the most inert molecules on earth. Constituting over 78 % of the air ... more
Duplicate or mirror? Laser light determines chirality of molecules
Seven of the ten most frequent medications contain chiral agents. These are molecules that occur in right- or left-handed forms. During chemical synthesis both forms usually occur in equal parts and have to be separated afterward, because chirality determines the agent’s effect in the body. ... more
From feast to famine and back – no problem for bacteria
Bacteria are true survivors. In the course of evolution, they have developed numerous strategies to adapt to rapidly changing, uncertain environmental conditions. Their metabolism is much more sophisticated than that of human beings. Within minutes they can regulate their gene expression an ... more
Why biosimilars and not biogenerics?
Medicines produced using genetic techniques have existed since 2006, called “similar biological medicinal products” or “biosimilars”. Until a year ago, this was a fairly low-profile group, even in expert circles. This has all changed now, however, with the recent licensing of the first bios ... more
What would medicine be without drugs? But are these drugs being used optimally today? Not at all, as we now know thanks to the findings of molecular medicine. Because for the use of these drugs, it is important to observe two aspects: the disease and the patient. Only slowly is it becom ... more
Jörg Soppa, born in 1958, studied biochemistry in Tübingen and then went on to do his doctorate at the Max Planck Institute of Biochemistry in Martinsried near Munich. In 1990 he established his own research group there and held courses at the Institute of Genetics and Microbiology of Munic ... more
Theodor Dingermann, born 1948, studied pharmacy in Erlangen and received his doctor title in 1980 to become Dr. rer. nat. In 1990 he was offered the C4 professorship at the Institute for Pharmaceutical Biology, University of Frankfurt. From 2000 to 2004 he was President of the German Phar ... more
Wilhelm Püttmann studied chemistry at RWTH Aachen and the University of Cologne. He received his doctorate in organic synthesis under Professor Emanuel Vogel in Cologne in 1980. Following two years of postdoctoral work, he moved to the field of geochemical analysis, assuming the leadership ... more
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