Life on Earth runs in 24-hour cycles. From tiny bacteria to human beings, organisms adapt to alterations of day and night. External factors, such as changes in light and temperature, are needed to entrain the clock. Many metabolic processes are controlled by the endogenous clock. Scientists ... more
Prof. Dr. Dagmar Fischer
Friedrich-Schiller-Universität Jena, Institut für Pharmazie & Jena Center for Soft Matter
Dagmar Fischer is a licensed pharmacist before obtaining her doctorate in pharmaceutical technology and biopharmacy from the Philipps University of Marburg in 1997. After a period spent at Texas Tech University Health Sciences Center (USA), she gained several years' experience as Head of Preclinical Research & Development at Antisense Pharma GmbH before accepting a professorship in Pharmaceutical Technology at Friedrich Schiller University Jena in 2008.
Dagmar Fischer plays an active role in numerous scientific societies and organizations, including as Secretary General of the German Pharmaceutical Society (DPhG), Deputy Director and Member of the Jena Center for Soft Matter (JCSM), Founding Ambassador of the FSU Jena for the Faculty of Biological Sciences. She is also a member of the International Association for Pharmaceutical Technology (APV) and its Division “Education and Science” as well as the Controlled Release Society (CRS) Local Chapter Germany.
Her work focuses on the development of nanoparticulate drug delivery systems from natural and synthetic polymers as well as their testing in biopharmaceutical 2D and 3D in vitro models to characterize the drug transport in the body. A major topic is related to the aspect of nanosafety including the development of alternative animal methods according to the 3R concept.
- Techniques to formulate nanoparticles in lab scale and upscale
- Physicochemical characterization to describe nanoparticle characteristics including stability and degradation in physiological and simulated body fluids
- Biological short-term and long-term tests in cell culture, gene delivery and microbiology laboratories in skin, lung, intestine, tumor and blood brain barrier models
- Investigations using a shell-less hen’s egg model (toxicity, distribution, stability)
- Safe by design concepts
- GxP concepts and process development