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Physikalisch-Technische Bundesanstalt (PTB)
André Henrion, born in 1957, studied chemistry at Humboldt-University in Berlin, where he received his doctorate in 1988 in the field of Physical Organic Chemistry. After working at the Academy of Sciences in Berlin for a short period he moved on to the Physikalisch-Technische Bundesanstalt (PTB) in 1992. Since 2001 he has been Head of Working Group Bioorganic Mass Spectrometry as part of the Biochemistry Group within PTB.
Activities
Resulting from his scope of tasks at the PTB the activities of André Henrion are mainly focused on the quantitative analysis of diagnostic and therapeutic markers by mass spectrometry. Corresponding with recent developments in the area, his focus has shifted over the last 15 years from quantification of small organic molecules to peptides and proteins as analytical targets. Beyond this, needing to interpret large amounts of generated data has led to statistics, chemometrics and bioinformatics becoming further areas of his expertise. André Henrion has represented the PTB for over 20 years in the Organic Analysis and Protein Analysis Working Groups in BIPM (CCQM), is a member of the Working Group on Immunosuppressive Drugs within the Scientific Division of the IFCC and leads a Review Team at the Joint Committee for Traceability in Laboratory Medicine (JCTLM). He has co-authored 42 original works, four reviews or book chapters and a monograph.
Awards
André Henrion received the Emil-Fischer-Award of Humboldt-University Berlin in 1983 and a Best Paper Award of the Cooperation on International Traceability in Analytical Chemistry (CITAC) in 2010.
Focus
The Working Group of André Henrion mainly uses quantitative bottom-up (shotgun-) proteomics for the targeted quantification of proteins in clinical or biological samples. For the most accurate results, isotope labeled peptides or recombinant proteins are referred to as sources for internal standards. Complementary, label-free methods are being developed for the quantification of entire spectra of proteins (within proteomes) to allow for e.g. purity-determination of reference materials, making them potentially applicable for purity-monitoring of pharmaceutical products or for process control. Another area of interest is developing cross-linking mass spectrometry (XL-MS) to characterize protein-tertiary structures and protein-protein interactions.
Methods
World Metrology Day is celebrated annually on the 20th of May and this year’s focus on health provides an opportunity to emphasize the importance of comparable and reliable measurement (…)
World's first optical atomic clock with highly charged ions
Optical atomic clocks are the most accurate measuring instruments ever built and are becoming key tools for basic and applied research, for example to test the constancy of natural constants or for height measurements in geodesy. Now, researchers at the QUEST Institute at the Physikalisch-T ... more
Scientists from the Physikalisch-Technische Bundesanstalt (PTB) have implemented a novel pressure measurement method, quasi as a byproduct of the work on the "new" kelvin. In addition to being new, this procedure is a primary method, i.e. it only depends on natural constants. As an independ ... more
Don't Give the Slightest Chance to Toxic Elements in Medicinal Products
Lead, cadmium, mercury, and arsenic do not belong in medicinal products. International requirements for the quality of medicines have therefore become more stringent and introduced new control requirements. Hence, it makes sense to use high-accuracy reference solutions with defined contents ... more
The importance of traceability in laboratory medicine
World Metrology Day is celebrated annually on the 20th of May and this year’s focus on health provides an opportunity to emphasize the importance of comparable and reliable measurement results in laboratory medicine. more
How the Avogadro constant was measured for the last time
Since the 20th of May 2019, the mass unit kilogram is no longer defined by the international kilogram prototype but by the numerical value of the Planck constant, the most important fundamental constant in quantum physics. For this definition, the Planck constant needed to be measured with ... more
Natural constants take center stage
The 20th of May 2019 is a special day. From that day on, the old definitions of what a kilogram, a mole, an ampere and a kelvin represent, are history. The future of the International System of Units will see natural constants play the star roles. more
Gavin O’Connor was born in Dublin and completed a Diploma in analytical chemistry at Athlone Institute of Technology, Ireland, in 1993. He continued his studies in analytical chemistry to B.Sc. level in the UK before completing his PhD in mass spectrometry at the University of Plymouth in 1 ... more
Rüdiger Ohlendorf, born in 1959, studied chemical engineering with a focus on instrumental analysis at the Münster University of Applied Sciences. After working at ISAS (Institute for Spectrochemistry and Applied Spectroscopy) and at Schering AG, he moved on to the Physikalisch-Technische B ... more
Christine Brauckmann, born in 1985, studied chemistry at the Westfälischen Wilhelms-Universität Münster and received her diploma degree there. In 2012, she completed her PhD in analytical chemistry with its focus on speciation analysis and started working at the Physikalisch-Technische Bund ... more
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