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Technische Universität Wien, Institut für Angewandte Synthesechemie
Sarah Spitz, born in 1993, studied biotechnology at the University of Natural Resources and Applied Life Sciences (BOKU) in Vienna, graduating with an engineering diploma degree. While studying, she was employed for two years as a research assistant at the Department of Biotechnology (DBT) at BOKU. She completed her inter-institutional master’s thesis at the Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, the TU Wien (Vienna University of Technology) and the Medical University of Vienna. In 2017, Sarah Spitz accepted a PhD position in the “Cell Chip Group” of Professor Dr. Ertl at TU Wien, where she is researching to develop a physiological midbrain model to investigate neurodegenerative processes in Parkinson's disease. Sarah Spitz works as a project assistant at TU Wien and is project leader of several, partly international, projects.
Activities
As part of Professor Dr. Ertl’s research group at the TU Wien, Sarah Spitz uses the advantages of organ-on-a-chip technology and its microfluidics to study Parkinson's disease, the second most common neurodegenerative disease worldwide. Human induced pluripotent stem cells (iPS cells) are used to grow miniature models of the midbrain in cell culture, so-called midbrain organoids, that are not only electrophysiologically active but also exhibit characteristics of the human midbrain. The aim is to use a wide range of technologies to investigate differences between healthy and diseased brains under physiological conditions and thus to gain new insights into how the disease develops. The multisensory, personalized platform created in the course of this work was awarded the 2020 public choice Houska Prize in the category “Academic Research”.
Focus
Sarah Spitz works on researching and establishing complex neurobiological in vitro organ and disease models using credit card sized multisensory microchips. This novel technology helps to closely imitate and control human physiology and supports both basic research and precision medicine. As a member of the Cell Chip Group, Sarah Spitz's research focuses mainly on Parkinson's disease, but also on osteoarthritis and the vascular system.
Methods
The aim of personalized medicine (or precision medicine) is to take patients’ personal features into consideration as much as possible for their medical treatment, thereby going beyond the (…)
One has to look very closely to exactly understand what processes take place on the surfaces of catalysts. Solid catalysts are often finely structured materials made of tiny crystals. There are various microscopies to monitor chemical processes on such surfaces – they use, for example, ultr ... more
Miniaturized Lab-on-a-Chip for real-time Chemical Analysis of Liquids
An infrared sensor has been developed at TU Wien (Vienna) that analyses the content of liquids within the fraction of a second. In analytical chemistry, it is often necessary to accurately monitor the concentration change of certain substances in liquids on a time scale of seconds. Especial ... more
A Molecule of Light and Matter
A very special bonding state between atoms has been created in the laboratory for the first time: With a laser beam, atoms can be polarised so that they are positively charged on one side and negatively charged on the other. This makes them attract each other creating a very special bonding ... more
The search for APIs in the genome of fungi
Fungi hold enormous potential to discover new active pharmaceutical ingredients (APIs) and valuable substances, for example antibiotics, pigments and raw materials for biological plastics. While conventional discovery methods are reaching their limits, recent developments in bioinformatics ... more
The aim of personalized medicine (or precision medicine) is to take patients’ personal features into consideration as much as possible for their medical treatment, thereby going beyond the functional diagnosis of the disease. A promising concept that is gaining ever more attention and showi ... more
Christian Derntl, born in 1983, completed his diploma studies in microbiology and immunology at the University of Vienna. In 2014, he completed his PhD study in technical chemistry with distinction at TU Wien. The topic of his thesis was the regulation of cellulases in the fungus Trichoderm ... more
Peter Ertl, born in 1970, studied food and biotechnology at the University of Natural Resources and Applied Life Sciences, Vienna. He obtained a PhD in chemistry from the University of Waterloo, Canada, and subsequently spent several years as a postdoc at the University of California at Ber ... more
Prof. Dr. Marko D. Mihovilovic
Marko D. Mihovilovic graduated in technical chemistry at the Vienna University of Technology in 1993, also receiving his doctorate from the same university in 1996, in the field of organic synthetic chemistry. Post-doc placements as an Erwin Schrödinger scholarship holder then followed at t ... more
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