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Technische Universität Wien, Institut für Verfahrenstechnik, Umwelttechnik und Technische Biowissenschaften
Christian Derntl, born in 1983, completed his diploma studies in microbiology and immunology at the University of Vienna. In 2014, he completed his PhD study in technical chemistry with distinction at TU Wien. The topic of his thesis was the regulation of cellulases in the fungus Trichoderma reesei. In the following years, Christian Derntl remained at TU Wien and worked on the development of an artificial gene expression system in industrial fungi. In a side project he focused on the secondary metabolism in fungi, in which he acquired further valuable experience in 2017 and 2018 as a postdoc at Vienna’s University of Natural Resources and Life Sciences in the research group “Metabolomics and Bioactive Substances”. Subsequently, Christian Derntl returned to TU Wien to work as a university assistant, and since 2021 as a senior scientist in the research group “Synthetic Biology and Molecular Biotechnology”.
Leitmotif
Every problem has at least one solution.
Activities
Christian Derntl currently leads projects on “ribosomally synthesized and post-translationally modified peptides” (RiPPs) and the regulatory network for morphology and the secondary metabolism in fungi. The scientific topics cover various bioinformatics and biotechnological approaches to discover novel secondary metabolites. An important aspect is the development and establishment of different methods for efficient strain design. Christian Derntl is also involved in teaching at TU Wien, giving lectures in biology, microbiology, biochemistry and biotechnology.
Focus
Christian Derntl’s scientific focus is the discovery of novel secondary metabolites from fungi.
Methods
Fungi hold enormous potential to discover new active pharmaceutical ingredients (APIs) and valua-ble substances, for example antibiotics, pigments and raw materials for biological plastics (…)
What happens when a cat climbs onto a sunflower? The sunflower is unstable, will quickly bend, and the cat will fall to the ground. However, if the cat only needs a quick boost to catch a bird from there, then the sunflower can act as a "metastable intermediate step". This is essentially th ... more
Photocatalysis: the Nano-Sponge Revolution
Catalysts are often solid materials whose surface comes into contact with gases or liquids, thereby enabling certain chemical reactions. However, this means that any atoms of the catalyst that are not on the surface serve no real purpose. Therefore, it is important to produce extremely poro ... more
To establish a carbon-neutral circular economy in the future, technologies are needed that use carbon dioxide as a raw material. In the form of formate, CO2 can be metabolised by certain bacteria. Acetogens are a group of bacteria that can metabolise formate. For example, they form acetic a ... more
The search for APIs in the genome of fungi
Fungi hold enormous potential to discover new active pharmaceutical ingredients (APIs) and valua-ble substances, for example antibiotics, pigments and raw materials for biological plastics. While conventional discovery methods are reaching their limits, recent developments in bioinformatics ... more
The aim of personalized medicine (or precision medicine) is to take patients’ personal features into consideration as much as possible for their medical treatment, thereby going beyond the functional diagnosis of the disease. A promising concept that is gaining ever more attention and showi ... more
Sarah Spitz, born in 1993, studied biotechnology at the University of Natural Resources and Applied Life Sciences (BOKU) in Vienna, graduating with an engineering diploma degree. While studying, she was employed for two years as a research assistant at the Department of Biotechnology (DBT) ... more
Peter Ertl, born in 1970, studied food and biotechnology at the University of Natural Resources and Applied Life Sciences, Vienna. He obtained a PhD in chemistry from the University of Waterloo, Canada, and subsequently spent several years as a postdoc at the University of California at Ber ... more
Prof. Dr. Marko D. Mihovilovic
Marko D. Mihovilovic graduated in technical chemistry at the Vienna University of Technology in 1993, also receiving his doctorate from the same university in 1996, in the field of organic synthetic chemistry. Post-doc placements as an Erwin Schrödinger scholarship holder then followed at t ... more
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