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Personalized drug therapy, adjusting the dose, dosage intervals, and the duration of treatment to fit individual patients' needs, are getting more and more important. Frequently, medications are dosed in such a way that each patient receives the same standardized amount of a certain drug. Thereby, clinical conditions of the patient, such as state of health, metabolism, or other physical factors, are often not sufficiently considered. A researcher team at the University of Freiburg has developed a bioanalytical method which can measure the class of β-lactam antibiotics in human blood on-site – in the operating room, intensive ward or doctor's office, as well as on a house call. "This way, we can easily determine just how quickly the human body metabolizes a drug," said the microsystems engineer Dr. Can Dincer, who is the head of the research team. The researchers recently published their results in the journal "Scientific Reports".
This new method makes it possible to individually adjust the necessary dose of a medication for each patient. "We've proven the applicability of our system for a personalized antibiotherapy by on-site monitoring the clearance of drugs in two patients, who were treated with ß-lactam antibiotics, undergoing surgery" Dincer said. "Based on these results, our next step will be to perform a quantitative cohort study that will determine the usefulness of personalized antibiotherapy.", he added.
Already at the end of 2016, the research team presented its biosensor technology that allows the rapid and simultaneous monitoring of different antibiotics in human blood. In their recently published study, the scientists further developed their system by implementing another natural sensor protein that can quantify β-lactam antibiotics. In human medicine, β-lactam antibiotics are often used to prevent and treat infectious diseases.
Nine researchers from the University of Freiburg were involved in this interdisciplinary study: Richard Bruch, André Kling, Dr. Can Dincer and Prof. Dr. Gerald Urban from the Laboratory for Sensors of the Department of Microsystems Engineering (IMTEK); Balder Rebmann, Dr. Claire Chatelle and Prof. Dr. Wilfried Weber from the Synthetic Biology Lab of the excellence cluster BIOSS Centre for Biological Signalling Studies and the Faculty of Biology; as well as Dr. Steffen Wirth and Prof. Dr. Stefan Schumann from the Department of Anesthesiology and Critical Care of the University of Freiburg Medical Center.
Molecular structure of one of the most important receptors in the immune system unraveled
The surface of B cells is covered with antigen receptors with which they recognize invading pathogens such as bacteria and viruses. When a B cell receptor binds to an antigen, that is, to a foreign structure, the B cell is activated and triggers the production of antibodies. Antibodies are ... more
The greenhouse gas nitrous oxide (N2O) is produced as a by-product of industrial processes and through the use of fertilizers in agriculture. It is making a steadily growing contribution to climate change and the depletion of the ozone layer. It is so chemically unreactive that it remains i ... more
New discoveries about the origin of the brain’s immune system
What gets into the brain and what doesn’t is strictly regulated. Researchers at the Faculty of Medicine at the University of Freiburg have now studied phagocytes that coat the blood vessels in the brain and reinforce the blood-brain barrier. As the scientists from the Institute of Neuropath ... more
Modular biofactories at the cellular level
Despite his love for complex molecular architectures, this „dyed-in-the-wool“ bio-organic chemist has never embraced the conventional segregation of synthetic polymers and biological macromolecules. All molecules are composed of atoms, after all. Why make an artificial distinction? Why not ... more
From a pluripotent stem cell a muscle cell or a liver cell can form, which despite their difference in appearance, are genetically identical. From one and the same genotype, therefore, the most diverse phenotypes can be formed – epigenetics is making it possible! It is a very exciting area ... more
Stefan M. Schiller studied chemistry at Gießen (Mainz, Germany) and the University of Massachusetts, majoring in macromolecular chemistry and biochemistry. For his doctorate in biomimetic membrane systems he worked till 2003 at the Max Planck Institute for Polymer Research in Mainz. Researc ... more
Julia M. Wagner studied pharmacy in Freiburg (licensure 2008). Since 2008 she is a PhD student and research assistant in the group of Professor Dr. M. Jung. Her research focuses on the cellular effects of histone deacetylase inhibitors. more
Manfred Jung is a graduate of the University of Marburg, where he studied pharmacy (licensure 1990) and obtained his doctorate in pharmaceutical chemistry with Prof. Dr. W. Hanefeld. After a post-doctorate at the University of Ottawa, Canada, he began with independent research in 1994 at ... more
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