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Degradable sugar-based polymers may store and release useful molecular freight

Options for chemical plastic recycling

25-Jan-2021

Degradable, bio-based polymers offer options for chemical recycling, and they can be a tool to store and release useful molecules. Scientists have developed a class of sugar-based polymers that are degradable through acid hydrolysis. The researchers also integrated “cargo” molecules in the ...

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Inverted Fluorescence

Discovery of chromophores that emit light in the ultraviolet region when excited with visible light

23-Dec-2020

Fluorescence usually entails the conversion of light at shorter wavelengths to light at longer wavelengths. Scientists have now discovered a chromophore system that goes the other way around. When excited by visible light, the fluorescent dyes emit light in the ultraviolet region. According to ...

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Useful “Fake” Peptides

Oligourea foldamers mimic peptides’ alpha-helices and effectively bind to drug targets

09-Dec-2020

Some useful drugs consist of peptides acting on their protein targets. To make them more efficient and stable, scientists have found a way to replace crucial segments of the peptides with ureido units. These oligoureas, which are composed of urea-based units, fold into a structure similar to that ...

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Combination Therapy against Cancer

Synergistic anticancer therapy with two cell killer agent systems in one nanocapsule

15-Oct-2020

In their quest to destroy cancer cells, researchers are turning to combinational therapies more and more. Scientists from Germany and China have now combined a chemotherapeutic and photodynamic approach. All agents are encapsulated in nanocapsules with a protein shell to be delivered to the ...

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Cascades with carbon dioxide

Novel catalytic process for converting CO2 into valuable chemical intermediates in the form of cyclic carbonates

10-Sep-2020

Carbon dioxide (CO2) is not just an undesirable greenhouse gas, it is also an interesting source of raw materials that are valuable and can be recycled sustainably. In the journal Angewandte Chemie, Spanish researchers have now introduced a novel catalytic process for convertingCO2 into valuable ...

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Better Than Cyclodextrins

Molecular Containers for the Sequestration of Neurotransmitter Drugs in Water

19-Jun-2020

Molecular containers that remove drugs, toxins, or malodorous substances from the environment are called sequestering agents. Scientists have developed a class of molecular containers that specifically sequester neurotransmitter antagonists. The barrel-shaped molecules called Pillar[n]MaxQ bind ...

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Staining Cycles with Black Holes

Ultrafast repeated staining and destaining of cell samples for tumor diagnostics

27-Mar-2020

In the treatment of tumors, microenvironment plays an important role. It often contains immune cells that are so changed that they promote tumor growth. In the journal Angewandte Chemie, scientists have introduced a method by which cell samples from tumors and their surroundings can rapidly ...

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Amplification and imaging of microRNA as a biomarker to detect tumor development

Cancer Diagnostics

18-Mar-2020

A good indicator of dysregulation in live cells is a change in their RNA expression. MicroRNA (miRNA), a special type of RNA, is considered a biomarker for carcinogenic cells. A team of scientists from China has found a way to amplify miRNA in live tumor cells for bioimaging. As they report in ...

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One Drug, Three Action Modes

Chemotherapy and photodynamic therapy combined in a single drug to fight resistant cancers

17-Mar-2020

Clinicians combat the drug resistances of some cancer types by using a combination of different drugs. To make this approach more effective, chemists have designed a chemical conjugate that can simultaneously attack several cellular targets using different modes of action. Such a single-drug ...

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Making Puffer Fish Toxin in a Flask

Total synthesis of tetrodotoxin

10-Mar-2020

In Japan, puffer fish is considered a delicacy, but the tickle to the taste buds comes with a tickle to the nerves: fugu contains tetrodotoxin, a strong nerve toxin. In low doses, tetrodotoxin is shown in clinical trials to be a replacement for opioids for relieving cancer related pain. In the ...

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