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Staining Cycles with Black Holes

Ultrafast repeated staining and destaining of cell samples for tumor diagnostics

27-Mar-2020

In the treatment of tumors, microenvironment plays an important role. It often contains immune cells that are so changed that they promote tumor growth. In the journal Angewandte Chemie, scientists have introduced a method by which cell samples from tumors and their surroundings can rapidly ...

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Amplification and imaging of microRNA as a biomarker to detect tumor development

Cancer Diagnostics

18-Mar-2020

A good indicator of dysregulation in live cells is a change in their RNA expression. MicroRNA (miRNA), a special type of RNA, is considered a biomarker for carcinogenic cells. A team of scientists from China has found a way to amplify miRNA in live tumor cells for bioimaging. As they report in ...

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One Drug, Three Action Modes

Chemotherapy and photodynamic therapy combined in a single drug to fight resistant cancers

17-Mar-2020

Clinicians combat the drug resistances of some cancer types by using a combination of different drugs. To make this approach more effective, chemists have designed a chemical conjugate that can simultaneously attack several cellular targets using different modes of action. Such a single-drug ...

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Making Puffer Fish Toxin in a Flask

Total synthesis of tetrodotoxin

10-Mar-2020

In Japan, puffer fish is considered a delicacy, but the tickle to the taste buds comes with a tickle to the nerves: fugu contains tetrodotoxin, a strong nerve toxin. In low doses, tetrodotoxin is shown in clinical trials to be a replacement for opioids for relieving cancer related pain. In the ...

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Autonomous Microtrap for Pathogens

Self-propelled onion-like microvehicle can attract, trap, and destroy biological threats

03-Feb-2020

Antibiotics are more efficient when they can act on their target directly at the site of infestation, without dilution. In the journal Angewandte Chemie, American scientists describe a synthetic chemical trap that propels itself to its place of action in the body fluid and then lures the bacteria ...

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Taking Aim at Gastric Cancer

New approach to selective chemotherapy

27-Jan-2020

A novel drug, named “FerriIridium”, can simultaneously help diagnose and treat gastric cancer. The initially weakly active precursor (prodrug), based on an iridium-containing compound, is selectively activated only after reaching the interior of a tumor cell. This is possible because of the ...

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Lights on for Germ-Free Wound Dressings

Biomimetic hydrogel with photodynamic antimicrobial effect

21-Jan-2020

Infections are a dreaded threat that can have fatal consequences after an operation, in the treatment of wounds, and during tissue engineering. Biomimetic hydrogels with “built-in” antimicrobial properties can significantly decrease this danger. In the journal Angewandte Chemie, scientists have ...

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Sensing Protein Wellbeing

Molecular probe maps misfolded proteome state in live cells

13-Jan-2020

The folding state of the proteins in live cells often reflect the cell’s general health. Australian scientists have developed a molecular probe that senses the state of the proteome—the entire set of the proteins—by measuring the polarity of the protein environment. The fluorescence signal of the ...

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Pathways toward Post-Petrochemistry

Electroreduction of carbon monoxide for the highly selective production of ethylene

13-Dec-2019

Ethylene, or ethene, is a primary feedstock for the chemical industry, including as a starting material for the production of a wide variety of plastics. In the journal Angewandte Chemie, scientists have now introduced a new electrochemical technique for selective and energy-efficient production ...

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Separating Drugs with MagLev

Magneto-Archimedes levitation for identification of illicit drugs in powdered mixtures

11-Dec-2019

The composition of suspicious powders that may contain illicit drugs can be analyzed using a quick and simple method called magneto-Archimedes levitation (MagLev), according to a new study published in the journal Angewandte Chemie. A team of scientists at Harvard University, USA, has developed ...

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