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The predictive power of blood: metabolomic profiling reveals risk of multiple diseases all at once

Striving for early risk identification and preventive action


To prevent diseases from occurring in the first place, it is important to identify those individuals who are at particularly high risk as early as possible. Yet current screening methods are often costly and focus only on one disease at a time. Scientists from the Berlin Institute of Health at ...


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The subtle difference: Pancreatic tumor organoids pave the way for single-cell diagnostics

A valuable experimental model for future therapies


The prognosis for pancreatic cancer is usually grim: The tumors are often detected too late and are then difficult to treat. Yet a small percentage of patients survive many years after diagnosis. Scientists from the Berlin Institute of Health at Charité (BIH) have now grown organoids from various ...


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The dangerous dual role of the immune system in COVID-19

Immune cells occasionally overshoot the mark and, due to their excessive reaction, sometimes cause greater damage than the virus itself


Infection with the novel coronavirus SARS-CoV-2 follows a highly variable course: some of those infected do not even notice it, while others become so seriously ill that their lives are placed at risk. Scientists from the Berlin Institute of Health (BIH) and Charité – Universitätsmedizin Berlin ...


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Fine-tuning gene scissors

Computer model for adjusting CRISPR-Cas9 enables more precise cuts in the genome


The CRISPR-Cas9 gene-editing tool makes it possible to modify the genetic material of organisms. But CRISPR technology is not perfect. Frequently, these molecular “scissors” also make incisions in genetic regions that have a similar appearance to the target sequence. Researchers at the Berlin ...


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DNA saturation mutagenesis: Identifying which mutations really cause disease


Scientists at the Berlin Institute of Health (BIH) and Charité – Universitätsmedizin Berlin, working with colleagues from the United States, have selectively modified the control regions of 20 disease-relevant genes. This enabled them to identify precisely those modifications that have the ...


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