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15 Current news of charit
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SARS-CoV-2 disrupts timing of immune response
Researchers anticipate that the timely inhibition of TGFβ could prevent progression to severe COVID-19
27-Oct-2021
Once an infection is under control, the body normally uses a biochemical messenger known as TGFβ to downgrade its immune response. In severe COVID-19, however, this messenger is released at the very beginning of the infection, thus blocking the early control of the pathogen by the innate immune ...
COVID-19: What is driving the escalating hyperinflammation
Study published in Nature suggests novel treatment option
15-Sep-2021
The severity of COVID-19 is not determined solely by the SARS-CoV-2 virus itself; rather, it is the primary result of a dysregulated immune response. A team of researchers from Charité – Universitätsmedizin Berlin, the Max-Delbrück-Center for Molecular Medicine (MDC), Johannes Kepler University ...
How the immune system paves the way for SARS-CoV-2
SARS-CoV-2 uses an immune system defense mechanism as a port of entry
22-Feb-2021
The immune system actually wants to fight SARS-CoV-2 with antiviral signaling molecules. But a research team from Charité and MDC has now shown how such a signaling molecule can promote the replication of the virus. Most people infected with SARS-CoV-2 are able to recover from the disease at home ...
How SARS-CoV-2 reaches the brain
For the first time electron microscope images of intact coronavirus particles inside the olfactory mucosa produced
01-Dec-2020
Using post-mortem tissue samples, a team of researchers from Charité – Universitätsmedizin Berlin have studied the mechanisms by which the novel coronavirus can reach the brains of patients with COVID-19, and how the immune system responds to the virus once it does. The results, which show that ...
Highly effective antibodies against the coronavirus were identified
Berlin scientists lay basis for a passive vaccination
25-Sep-2020
Researchers at the German Center for Neurodegenerative Diseases (DZNE) and Charité - Universitätsmedizin Berlin have identified highly effective antibodies against the coronavirus SARS-CoV-2 and are now pursuing the development of a passive vaccination. In this process, they have also discovered ...
Could the blood of COVID-19 patients be used to predict disease progression?
Study discovers differences in the blood samples of severe and mild cases
09-Jun-2020
Researchers from Charité – Universitätsmedizin Berlin and the Francis Crick Institute have identified 27 proteins which are present at different levels in the blood of COVID-19 patients, depending on the severity of their symptoms. These biomarker profiles could be used to predict disease ...
Preventing spread of SARS coronavirus-2 in humans
Infection researchers identify potential drug
09-Mar-2020
Viruses must enter cells of the human body to cause disease. For this, they attach to suitable cells and inject their genetic information into these cells. Infection biologists from the German Primate Center - Leibniz Institute for Primate Research in Göttingen, together with colleagues at ...
Hundreds of novel viruses discovered in insects
10-Jan-2020
New viruses which cause diseases often come from animals. Well-known examples of this are the Zika virus transmitted by mosquitoes, bird flu viruses, as well as the MERS virus which is associated with camels. In order to identify new viral diseases quickly and prevent possible epidemics, DZIF ...
DNA saturation mutagenesis: Identifying which mutations really cause disease
15-Aug-2019
Scientists at the Berlin Institute of Health (BIH) and Charité – Universitätsmedizin Berlin, working with colleagues from the United States, have selectively modified the control regions of 20 disease-relevant genes. This enabled them to identify precisely those modifications that have the ...
Stem cells moonlight to protect the stomach from bacterial invaders
A subpopulation of stem cells releases antimicrobial peptides to defend the gastric mucosa against pathogenic bacteria
01-Jul-2019
Our mucosal surfaces are constantly exposed to numerous bacterial species, some of which can induce DNA damage in host cells. Normally this remains inconsequential, as the rapid turnover of the mucosa means damaged cells are shed within days. However, if the long-lived stem cells that continually ...
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