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The predictive power of blood: metabolomic profiling reveals risk of multiple diseases all at once

Striving for early risk identification and preventive action


To prevent diseases from occurring in the first place, it is important to identify those individuals who are at particularly high risk as early as possible. Yet current screening methods are often costly and focus only on one disease at a time. Scientists from the Berlin Institute of Health at ...


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The ‘selenosome’: The choreography which governs recoding

Cryo-electron microscopy visualizes cellular structures


A team led by researchers from Charité – Universitätsmedizin Berlin has succeeded in deciphering a fundamental process of molecular biology: the incorporation of selenocysteine – the ‘21st amino acid’ – into selenium-containing proteins known as selenoproteins. These protein constructions are ...


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Fungal infections: Microbial cooperation leads to drug tolerance

Fungal infections represent an increasingly significant health issue and are more dangerous than previously thought


The treatment of fungal infections is often hampered by fungal pathogens that do not respond, or are tolerant, against anti-fungal drugs. A team of researchers from Charité – Universitätsmedizin Berlin and the Francis Crick Institute have now identified microbial cooperation as one of the causes ...


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Corona: New Insights into Antibody Response against Viral Variants

Cross-reactivity could prove to be an important aspect of future vaccinations


In the journal Science, researchers from Charité – Universitätsmedizin Berlin and Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE) present new findings on the immune response against the coronavirus SARS-CoV-2. Their study is based on investigations of antibodies elicited by infection ...


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SARS-CoV-2 disrupts timing of immune response

Researchers anticipate that the timely inhibition of TGFβ could prevent progression to severe COVID-19


Once an infection is under control, the body normally uses a biochemical messenger known as TGFβ to downgrade its immune response. In severe COVID-19, however, this messenger is released at the very beginning of the infection, thus blocking the early control of the pathogen by the innate immune ...


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COVID-19: What is driving the escalating hyperinflammation

Study published in Nature suggests novel treatment option


The severity of COVID-19 is not determined solely by the SARS-CoV-2 virus itself; rather, it is the primary result of a dysregulated immune response. A team of researchers from Charité – Universitätsmedizin Berlin, the Max-Delbrück-Center for Molecular Medicine (MDC), Johannes Kepler University ...


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How the immune system paves the way for SARS-CoV-2

SARS-CoV-2 uses an immune system defense mechanism as a port of entry


The immune system actually wants to fight SARS-CoV-2 with antiviral signaling molecules. But a research team from Charité and MDC has now shown how such a signaling molecule can promote the replication of the virus. Most people infected with SARS-CoV-2 are able to recover from the disease at home ...


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How SARS-CoV-2 reaches the brain

For the first time electron microscope images of intact coronavirus particles inside the olfactory mucosa produced


Using post-mortem tissue samples, a team of researchers from Charité – Universitätsmedizin Berlin have studied the mechanisms by which the novel coronavirus can reach the brains of patients with COVID-19, and how the immune system responds to the virus once it does. The results, which show that ...


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Highly effective antibodies against the coronavirus were identified

Berlin scientists lay basis for a passive vaccination


Researchers at the German Center for Neurodegenerative Diseases (DZNE) and Charité - Universitätsmedizin Berlin have identified highly effective antibodies against the coronavirus SARS-CoV-2 and are now pursuing the development of a passive vaccination. In this process, they have also discovered ...


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Could the blood of COVID-19 patients be used to predict disease progression?

Study discovers differences in the blood samples of severe and mild cases


Researchers from Charité – Universitätsmedizin Berlin and the Francis Crick Institute have identified 27 proteins which are present at different levels in the blood of COVID-19 patients, depending on the severity of their symptoms. These biomarker profiles could be used to predict disease ...


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