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Fungal infections: Microbial cooperation leads to drug tolerance

Fungal infections represent an increasingly significant health issue and are more dangerous than previously thought

28-Mar-2022

The treatment of fungal infections is often hampered by fungal pathogens that do not respond, or are tolerant, against anti-fungal drugs. A team of researchers from Charité – Universitätsmedizin Berlin and the Francis Crick Institute have now identified microbial cooperation as one of the causes ...

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Corona: New Insights into Antibody Response against Viral Variants

Cross-reactivity could prove to be an important aspect of future vaccinations

27-Jan-2022

In the journal Science, researchers from Charité – Universitätsmedizin Berlin and Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE) present new findings on the immune response against the coronavirus SARS-CoV-2. Their study is based on investigations of antibodies elicited by infection ...

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SARS-CoV-2 disrupts timing of immune response

Researchers anticipate that the timely inhibition of TGFβ could prevent progression to severe COVID-19

27-Oct-2021

Once an infection is under control, the body normally uses a biochemical messenger known as TGFβ to downgrade its immune response. In severe COVID-19, however, this messenger is released at the very beginning of the infection, thus blocking the early control of the pathogen by the innate immune ...

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COVID-19: What is driving the escalating hyperinflammation

Study published in Nature suggests novel treatment option

15-Sep-2021

The severity of COVID-19 is not determined solely by the SARS-CoV-2 virus itself; rather, it is the primary result of a dysregulated immune response. A team of researchers from Charité – Universitätsmedizin Berlin, the Max-Delbrück-Center for Molecular Medicine (MDC), Johannes Kepler University ...

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How the immune system paves the way for SARS-CoV-2

SARS-CoV-2 uses an immune system defense mechanism as a port of entry

22-Feb-2021

The immune system actually wants to fight SARS-CoV-2 with antiviral signaling molecules. But a research team from Charité and MDC has now shown how such a signaling molecule can promote the replication of the virus. Most people infected with SARS-CoV-2 are able to recover from the disease at home ...

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How SARS-CoV-2 reaches the brain

For the first time electron microscope images of intact coronavirus particles inside the olfactory mucosa produced

01-Dec-2020

Using post-mortem tissue samples, a team of researchers from Charité – Universitätsmedizin Berlin have studied the mechanisms by which the novel coronavirus can reach the brains of patients with COVID-19, and how the immune system responds to the virus once it does. The results, which show that ...

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Highly effective antibodies against the coronavirus were identified

Berlin scientists lay basis for a passive vaccination

25-Sep-2020

Researchers at the German Center for Neurodegenerative Diseases (DZNE) and Charité - Universitätsmedizin Berlin have identified highly effective antibodies against the coronavirus SARS-CoV-2 and are now pursuing the development of a passive vaccination. In this process, they have also discovered ...

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Could the blood of COVID-19 patients be used to predict disease progression?

Study discovers differences in the blood samples of severe and mild cases

09-Jun-2020

Researchers from Charité – Universitätsmedizin Berlin and the Francis Crick Institute have identified 27 proteins which are present at different levels in the blood of COVID-19 patients, depending on the severity of their symptoms. These biomarker profiles could be used to predict disease ...

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Preventing spread of SARS coronavirus-2 in humans

Infection researchers identify potential drug

09-Mar-2020

Viruses must enter cells of the human body to cause disease. For this, they attach to suitable cells and inject their genetic information into these cells. Infection biologists from the German Primate Center - Leibniz Institute for Primate Research in Göttingen, together with colleagues at ...

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Hundreds of novel viruses discovered in insects

10-Jan-2020

New viruses which cause diseases often come from animals. Well-known examples of this are the Zika virus transmitted by mosquitoes, bird flu viruses, as well as the MERS virus which is associated with camels. In order to identify new viral diseases quickly and prevent possible epidemics, DZIF ...

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