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DNA saturation mutagenesis: Identifying which mutations really cause disease

15-Aug-2019

Scientists at the Berlin Institute of Health (BIH) and Charité – Universitätsmedizin Berlin, working with colleagues from the United States, have selectively modified the control regions of 20 disease-relevant genes. This enabled them to identify precisely those modifications that have the ...

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Stem cells moonlight to protect the stomach from bacterial invaders

A subpopulation of stem cells releases antimicrobial peptides to defend the gastric mucosa against pathogenic bacteria

01-Jul-2019

Our mucosal surfaces are constantly exposed to numerous bacterial species, some of which can induce DNA damage in host cells. Normally this remains inconsequential, as the rapid turnover of the mucosa means damaged cells are shed within days. However, if the long-lived stem cells that continually ...

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How Artificial Intelligence Detects Rare Diseases

11-Jun-2019

Every year, around half a million children worldwide are born with a rare hereditary disease. Obtaining a definitive diagnosis can be difficult and time consuming. In a study of 679 patients with 105 different rare diseases, scientists from the University of Bonn and the Charité - ...

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Prostate cancer – New computer model enables researchers to predict course of disease

18-Dec-2018

How does a normal cell turn into a deadly cancer? Seeking an answer to this question, and working alongside other international working groups, researchers from Charité – Universitätsmedizin Berlin examined the tumor genomes of nearly 300 prostate cancer patients. Their findings describe the ways ...

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Quality control inside the cell

How rescue proteins dispose of harmful messages

23-Jan-2017

The ability to dispose of proteins that are either aberrant or (in the worst case) toxic is fundamental to a cell's survival. Researchers from Charité - Universitätsmedizin Berlin have been able to demonstrate the manner in which two specific proteins recognize defective messenger RNAs (molecules ...

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Nanostructures in human teeth

06-Jun-2016

Dentin is one of the most durable biological materials in the human body. Researchers from Charité–Universitätsmedizin Berlin were able to show that the reason for this can be traced to its nanostructures and specifically to the interactions between the organic and inorganic components. ...

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Strong teeth: Nanostructures under stress make teeth crack resistant

16-Jun-2015

Human teeth have to serve for a lifetime, despite being subjected to huge forces. But the high failure resistance of dentin in teeth is not fully understood. An interdisciplinary team led by scientists of Charite Universitaetsmedizin Berlin has now analyzed the complex structure of dentin. At the ...

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