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Rapid emergence of antibiotic resistance during standard therapy

How the pathogen Pseudomonas aeruginosa becomes resistant to antibiotics

25-Nov-2019

Antibiotic-resistant pathogens pose one of the greatest threats to public health worldwide. In the near future, harmless bacterial infections may no longer be treatable and may again become the most common non-natural cause of death. At the same time, the available repertoire of antibacterial ...

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Kiel Möbius Prize goes to renowned American microbiome researcher

15-Nov-2019

Tuesday, November 12, the Collaborative Research Centre (CRC) 1182 "Origin and Function of Metaorganisms" at Kiel University awarded its most important science prize, the Karl August Möbius-Fellowship, for the third time. This year's winner is the American physician and microbiologist Professor ...

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New strategies against the antibiotics crisis

Evolutionary principles improve treatment efficacy

31-Oct-2019

One of the most serious threats to public health worldwide is posed by antibiotic-resistant pathogens. The World Health Organization (WHO) warns of the imminent beginning of a postantibiotic era in which harmless infections can no longer be treated and could once again become one of the most ...

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The best of both worlds: a designer molecule to combat type 2 diabetes

30-Sep-2019

A team of scientists from Kiel and Melbourne have developed a new protein from two naturally occurring proteins, which has proven very effective against type 2 diabetes in laboratory experiments. Scientists led by Professor Stefan Rose-John, a biochemist at Kiel University (CAU) and member of the ...

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Plan B for Cholesterol Transport

Research team proves the existence of a previously unknown alternative cholesterol transport mechanism inside cells

16-Aug-2019

Cholesterol is a vital cell building block in humans and animals, and an integral part of the so-called cell membrane. This boundary layer separates the interior of the cell from the neighbouring cells and the surrounding environment. By means of certain proteins, it ensures that various chemical ...

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Towards a light driven molecular assembler

Chemists at Kiel University built the first artificial molecular machines that performs synthesis

25-Jul-2019

Chemists usually synthesize molecules using stochastic bond-forming collisions of the reactant molecules in solution. Nature follows a different strategy in biochemical synthesis. The majority of biochemical reactions are driven by machine-type protein complexes that bind and position the ...

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Over-fed bacteria make people sick

17-May-2019

Since the end of the Second World War, along with the growing prosperity and the associated changes in lifestyle, numerous new and civilisation-related disease patterns have developed in today's industrialised nations. Examples of the so-called "environmental diseases" are different bowel ...

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Intestinal microbiota defend the host against pathogens

04-Mar-2019

From single-celled organisms to humans, all animals and plants are colonised by microorganisms. As so-called host organisms, they accommodate a diverse community of symbiotic microorganisms, the microbiome, and together with them form the so-called metaorganism. The interactions between host and ...

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Cellular memory outwits pathogens

Study proves effectiveness of sequential antibiotic treatment against the pathogen Pseudomonas aeruginosa

14-Sep-2018

The World Health Organization (WHO) warns that seemingly harmless bacterial infections could develop into one of the leading causes of death in the next few years, particularly in the industrialised countries. This dramatic threat arose because, in many cases, the antibiotics that have been ...

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Stone age hepatitis B virus decoded

Viral DNA shows the hepatitis B virus has been circulating in Europe for at least 7.000 years

14-May-2018

An international team of scientists led by researchers at Kiel University in the scope the CRC 1266 “Scales of Transformation” and the Max Planck Institute for the Science of Human History has successfully reconstructed genomes from Stone Age and Medieval European strains of the hepatitis B ...

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