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13 Current news of Deutsches Krebsforschungszentrum
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Induced pluripotent stem cells reveal causes of disease
Using single-cell analyses, researchers systematically searched for correlations between individual genetic variants in induced pluripotent stem cells
08-Mar-2021
Induced pluripotent stem cells (iPSC) are suitable for discovering the genes that underly complex and also rare genetic diseases. Scientists from the German Cancer Research Center (DKFZ) and the European Molecular Biology Laboratory (EMBL), together with international partners, have studied ...
New technology provides insight into the development of immune cells
Barcode system enables researchers to follow which development path the cells take at the same time as identifying which genes are actively transcribed as messenger RNAs
14-Aug-2020
The entire range of our blood and immune cells are derived from hematopoietic stem cells. Yet which genes influence how they develop into the different cell types? Scientists from the German Cancer Research Center (DKFZ) have now developed a new technology to answer this question. A genetic ...
Preventing metastasis - an antibody with therapeutic potential
New principle for slowing down the metastatic dissemination of cancer cells
04-May-2020
A receptor in the cell layer that lines the blood vessels from the inside stimulates both the formation of new blood vessels in tumors and metastasis. Scientists at the German Cancer Research Center in Heidelberg (DKFZ) and the Mannheim Medical Faculty of the University of Heidelberg have ...
Potential pivot for a more effective cancer immunotherapy
31-Jan-2020
Scientists from the Biomedical Research Foundation of the Academy of Athens (Greece), the Institute of Clinical Chemistry and Laboratory Medicine of the Carl Gustav Carus University Hospital Dresden and the National Center for Tumor Diseases Dresden (NCT/UCC), in collaboration with an ...
How dying cells prevent dangerous immune reactions
14-Jan-2020
Dying cells in the body can keep the immune system in check, thus preventing unwanted immune responses against the body's own tissues. Scientists of the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) have now identified a receptor on immune cells that activates this ...
Cell death or cancer growth: a question of cohesion
21-Nov-2019
Activation of CD95, a receptor found on all cancer cells, triggers programmed cell death – or does the opposite, namely stimulates cancer cell growth. Scientists from the German Cancer Research Center (DKFZ) have now shown that the impact of CD95 activation depends on whether there are isolated ...
Protein misfolding as a risk marker for Alzheimer’s disease – up to 14 years before the diagnosis
17-Oct-2019
In symptom-free individuals, the detection of misfolded amyloid-β protein in the blood indicated a considerably higher risk of Alzheimer's disease – up to 14 years before a clinical diagnosis was made. Amyloid-β folding proved to be superior to other risk markers evaluated, as shown by scientists ...
Making cancer stem cells visible to the immune system
New results may enable innovative treatment concept against leukemia
19-Jul-2019
Leukemia stem cells protect themselves against the immune defense by suppressing a target molecule for killer cells. This protective mechanism can be tricked with drugs. In the journal "Nature", scientists from Basel, Tübingen and Heidelberg describe the new therapeutic approaches that can ...
Targeted approach to therapy for rare type of bone cancer
12-Apr-2019
Chordomas are rare bone tumors for which only few options of treatment exist. Scientists and doctors from the National Center for Tumor Diseases (NCT) Heidelberg, the German Cancer Research Center (DKFZ), and Heidelberg University Hospital (UKHD) have discovered a particular genetic trait of ...
Protein content as a marker for response to therapy in brain cancer
Look into the future in fact seems possible
06-Mar-2019
Brain tumors vary widely in how they respond to treatment. However, early assessment of therapy response is essential in order to choose the best possible treatment for the patient. Scientists from the German Cancer Research Center (DKFZ) have now been able to show in a study using non-invasive ...
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