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Tackling the collateral damage from antibiotics

Scientists pave the way for reducing the harmful side effects antibiotics have on gut bacteria

15-Oct-2021

Antibiotics help us to treat bacterial infections and save millions of lives each year. But they can also harm the helpful microbes residing in our gut, weakening one of our body’s first lines of defence against pathogens and compromising the multiple beneficial effects our microbiota has for our ...

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Induced pluripotent stem cells reveal causes of disease

Using single-cell analyses, researchers systematically searched for correlations between individual genetic variants in induced pluripotent stem cells

08-Mar-2021

Induced pluripotent stem cells (iPSC) are suitable for discovering the genes that underly complex and also rare genetic diseases. Scientists from the German Cancer Research Center (DKFZ) and the European Molecular Biology Laboratory (EMBL), together with international partners, have studied ...

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Replication cycle of SARS-CoV-2 in 3D

Learning how SARS-CoV-2 highjacks host cell machineries will help to develop therapeutic strategies

25-Nov-2020

As the global coronavirus pandemic continues, scientists are not only trying to find vaccines and drugs to combat it, but also to continuously learn more about the virus itself. “By now we can expect the coronavirus to become seasonal,” explains Ralf Bartenschlager, professor in the Department of ...

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Scientists identify synthetic mini-antibody to combat COVID-19

By screening hundreds of synthetic mini-antibodies called sybodies, a group of scientists has identified one that might stop SARS-CoV-2 from infecting human cells

05-Nov-2020

The ability of SARS-CoV-2 to infect cells depends on interactions between the viral spike protein and the human cell surface protein ACE2. To enable the virus to hook onto the cell surface, the spike protein binds ACE2 using three finger-like protrusions, called the receptor binding domains ...

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Melting reveals drug targets in a living organism

Scientists identify drug targets in blood and organs

23-Jan-2020

Developing new medicines and understanding how they target specific organs often gives a crucial advantage in the fight against human diseases. An international team led by researchers at the European Molecular Biology Laboratory and Cellzome, a GSK company, has developed a technology to ...

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Toxin responsible for Legionella growth identified

24-Jul-2019

A team of scientists led by EMBL group leader Sagar Bhogaraju and Ivan Dikic of Goethe University, Frankfurt, discovered that the toxin SidJ in Legionella bacteria enforces a unique modification on human proteins and helps legionella grow inside human cells. SidJ hijacks human protein Calmodulin ...

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Snapshots of the flu virus replication machine in action

05-Jun-2019

Researchers from EMBL Grenoble have, for the first time, observed different functional states of the influenza virus polymerase as it is actively transcribing. These results, published in Nature Structural & Molecular Biology, provide valuable information for the next generation of anti-influenza ...

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Designer organelles bring new functionalities into cells

EMBL scientists create membraneless organelle to build proteins in living cell

01-Apr-2019

For the first time, scientists have engineered the complex biological process of translation into a designer organelle in a living mammalian s. Research by the Lemke group at the European Molecular Biology Laboratory (EMBL) – in collaboration with JGU Mainz and IMB Mainz – used this technique to ...

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New Ways to Look at Protein-RNA Networks

10-Dec-2018

For their vital tasks, all RNA molecules in our cells require proteins as binding partners. Scientists at the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) and colleagues from the European Molecular Biology Laboratory (EMBL) have developed the first method with which they ...

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Combining antibiotics changes their effectiveness

06-Jul-2018

The effectiveness of antibiotics can be altered by combining them with each other, non-antibiotic drugs or even with food additives. Depending on the bacterial species, some combinations stop antibiotics from working to their full potential whilst others begin to defeat antibiotic resistance, ...

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