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14 Current news of Helmholtz-Zentrum für Infektionsforschung

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A tiny molecule with a big impact

Immunologists have deciphered a new role of nitric oxide in the defense against pathogens.

26-Oct-2021

Nitric oxide (NO) occurs naturally in the human body as a messenger substance. It is considered an all-rounder, as it performs numerous important regulatory functions, including immune defense against pathogens. The exact mode of action of this molecule has now been uncovered by immunologist ...

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CRISPR discovery paves the way for novel COVID testing method

LEOPARD has the potential to revolutionize diagnostics

29-Apr-2021

Am I infected with SARS-CoV-2? Is it one of the dangerous variants? Being able to answer these and more questions with a single efficient diagnostic test can be decisive for gauging the spread of disease and selecting the right therapy. In a study published in the journal "Science", researchers ...

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New Chance for Better Pandemic Response

Researchers succeed in developing neutralizing anti-SARS-CoV-2 antibodies from immune cells of healthy donors

16-Mar-2021

An international research team of the Technische Universität Braunschweig and the Helmholtz Centre for Infection Research (HZI), led by the Department of Biotechnology of the TU Braunschweig, has reported on the development of special antibodies against SARS-CoV-2 in the journal Nature ...

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Leap forward in the fight against antibiotic resistance

Researchers succeed in deep sequencing RNA of single bacteria

21-Aug-2020

Bacteria show a wide range of capabilities in withstanding antibiotic treatment or attack by our immune system, which are great challenges in infection research. Scientists at the Würzburg-based Helmholtz Institute for RNA-based Infection Research (HIRI), a site of the Helmholtz Centre for ...

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Researchers visualize the battle between virus and host cells at the single-cell level

An innovative method identifies newly activated genes within individual cells

12-Jul-2019

Cells are equipped with multiple defense mechanisms to fight off intruders. Genes encode the building blocks of the response that must be activated during an enemy attack in an ordered manner. Scientists at the Helmholtz Institute for RNA-based Infection Research (HIRI) in Würzburg, one of the ...

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How bacteria produce antibiotics

Researchers decipher important steps in the formation of a natural antibiotic

28-Jun-2019

In the 1950s, researchers discovered bottromycins – natural substances produced by bacteria with antibiotic activity. Since these substances even kill human pathogens such as the hospital germ MRSA (methicillin-resistant Staphylococcus areus), they are of interest for drug development. After the ...

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Eliminating hepatitis C viruses effectively

Researchers identify target on the viral envelope and develop customised agents

27-Mar-2019

The treatment of hepatitis C has been based on specific effective antiviral medications for a number of years. Since future development of resistance cannot be ruled out, alternative treatment options are being researched as well. So-called cell entry inhibitors are considered to be promising ...

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How bacteria turn off an antibiotic

19-Dec-2018

Many common antibiotics are increasingly losing their effectiveness against multi-resistant pathogens, which are becoming ever more prevalent. Bacteria use natural means to acquire mechanisms that protect them from harmful substances. For instance against the agent albicidin: Harmful ...

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Hospital germs have their flaws too

Researchers discovered a target for novel medications

09-Jul-2018

The hospital germ Pseudomonas aeruginosa can cause serious wound as well as lung and urinary tract infections, especially in weakened individuals. Pseudomonas manages time and again to survive attacks of the immune system and antibiotic therapies. One key to the success of this persistent ...

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Immortal cells for tailor-made active substances

12-Mar-2018

When scientists discover a new active substance, e.g. for use against a pathogen, they usually study its exact effect in cultured cells. But there is a lack of suitable test systems that simulate body tissues, because cells rapidly lose their specific properties once they are away from their ...

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