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29 Current news of Helmholtz Zentrum München
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AI helps to spot single diseased cells
01-Sep-2021
Researchers developed a novel artificial intelligence algorithm for clinical applications called “scArches”. It efficiently compares patients’ cells with a reference atlas of cells of healthy individuals. This enables physicians to pinpoint cells in disease and prioritize them for personalized ...
Pancreatic organoids on newly developed chip platform
29-Jul-2021
A new organoid-on-chip platform robustly mimics the key features of human pancreas development. This is a milestone on the way to being able to diagnose pancreatic cancer at an early stage in the future. The study was conducted by an interdisciplinary team of researchers from Helmholtz Zentrum ...
Revealing the secrets of cell competition
Which features distinguish “winner” from “loser” cells
23-Jul-2021
Cellular competition is a crucial quality control process that ensures that the development of an organism relies on healthy cells. Researchers revealed the secrets underlying cell competition and what features can pre-determine whether a cell will survive or not. Defects in energy production are ...
The Cut and Restore Protein Trick: Self-Excising Designer Proteins Report Isoform Expression
07-Jun-2021
Our proteome is much bigger than our genome because one gene produces several variants of proteins called protein isoforms, whose disbalance is implicated in many diseases. A new bioengineered reporter system developed at Helmholtz Zentrum München and the Technical University of Munich now allows ...
Sars-Cov-2 infects cells via specific viral entry factors that are more abundant in elderly, men and smokers
This could partially explain the differences of COVID-19 severity reported in relation to age, gender and smoking status
19-Mar-2021
A new study uncovers which cell types can be infected by SARS-CoV-2 due to their viral entry factors. The study also suggests that increased gene expression of these viral entry factors in some individuals partially explains the differences of COVID-19 severity reported in relation to age, gender ...
Animal-free method predicts nanoparticle toxicity for safer industrial materials
A step closer to safe-by-design material development
26-Nov-2020
Researchers at Helmholtz Zentrum München together with scientists across Europe developed a novel animal-free method to predict the toxic effect of nanoparticles to the human lung. The method aims to enable the safety-by-design development of safer industrial materials. Our lungs are exposed to a ...
New drug combination restores beta cell function in animal model
Potential for diabetes remission
24-Feb-2020
The loss of the identity of insulin-secreting beta cells in the islet of Langerhans, a process also called beta cell dedifferentiation, has been proposed to be a main reason for the development of diabetes. If and how dedifferentiated beta cells can be targeted by pharmacological intervention for ...
Unlimited potential: New ways to generate totipotent-like cells
13-Jan-2020
Totipotency is set to become a key tool for research and future medical applications. Finding efficient ways to generate totipotent-like cells is therefore crucial. In a new study, a group of researchers at Helmholtz Zentrum München found that totipotent-like cells can be induced by manipulating ...
Looking at the good vibes of molecules: a new method for label-free metabolic imaging
09-Jan-2020
Label-free dynamic detection of biomolecules is a major challenge in live-cell microscopy. The simultaneous visualization of dynamic alterations for classes of metabolites, such as carbohydrates and lipids, was an unmet need in biomedical research. Now, a novel imaging method developed by a ...
New algorithm detects even the smallest cancer metastases across the entire mouse body
Exposing the enemy
16-Dec-2019
Teams at Helmholtz Zentrum München, LMU Munich and the Technical University of Munich (TUM) have developed a new algorithm that enables automated detection of metastases at the level of single disseminated cancer cells in whole mice. Cancer is one of the leading causes of death worldwide. More ...
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