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How tiny changes help T cells survive

Essential function of m6A modifications in T cells revealed.

27-Jul-2022

The chemical modification of nucleic acids, known as methylation, exists not only on DNA but also on RNA. So far, it is still unclear whether this methylation is important for certain cell types and what effects it has on the interaction of cells in the body. The most abundant modification on ...

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The oat genome unlocks the unique health benefits of oats

Why oats are healthier and cause fewer allergies and intolerances than other cereals

20-May-2022

Researchers have succeeded in sequencing and characterizing the entire genome of oat. Compared to other cereals and humans, the oat genome architecture is very complex. Scientists from Helmholtz Munich, Lund University and the ScanOats network finally elucidated at the genetic level why oats are ...

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A Speed Limit Could Be a Breakthrough for Stem Cell Therapy

Less speed, improved cellular reprogramming

10-Mar-2022

Replacing sick or damaged cells with healthy cells: this is a major goal of regenerative medicine. One of the most promising approaches is cellular reprogramming, whereby one cell type in our body converts to another cell type. Research carried out at Helmholtz Munich and ...

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COVID-19: Breakthrough infection can substitute for a third vaccine shot

According to the study, this is possible in three constellations

03-Feb-2022

According to a new study led by Ulrike Protzer, a breakthrough infection after two vaccinations achieves the same protective effect as an additional booster vaccination. According to the study by Helmholtz Munich, LMU and TUM, the decisive factor for immunity is that the immune system has had ...

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A light in the dark tissue

Switchable proteins for biomedical imaging

09-Dec-2021

Biomedical imaging is the window through which we can look into organisms. It allows us to see cells, their behavior and localization that would otherwise be hidden. Tracking very few cells over time without damaging them is a key challenge in health research. For this purpose, Helmholtz Munich ...

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Fighting blood diseases with artificial intelligence

Largest open-source database for bone marrow cell images developed

24-Nov-2021

How can we better diagnose blood diseases? A research group led by Helmholtz Munich aims to answer this question with artificial intelligence (AI). Their goal is to facilitate the time-consuming analysis of bone marrow cells under the microscope. The researchers developed the largest open-source ...

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AI helps to spot single diseased cells

01-Sep-2021

Researchers developed a novel artificial intelligence algorithm for clinical applications called “scArches”. It efficiently compares patients’ cells with a reference atlas of cells of healthy individuals. This enables physicians to pinpoint cells in disease and prioritize them for personalized ...

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Pancreatic organoids on newly developed chip platform

29-Jul-2021

A new organoid-on-chip platform robustly mimics the key features of human pancreas development. This is a milestone on the way to being able to diagnose pancreatic cancer at an early stage in the future. The study was conducted by an interdisciplinary team of researchers from Helmholtz Zentrum ...

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Revealing the secrets of cell competition

Which features distinguish “winner” from “loser” cells

23-Jul-2021

Cellular competition is a crucial quality control process that ensures that the development of an organism relies on healthy cells. Researchers revealed the secrets underlying cell competition and what features can pre-determine whether a cell will survive or not. Defects in energy production are ...

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The Cut and Restore Protein Trick: Self-Excising Designer Proteins Report Isoform Expression

07-Jun-2021

Our proteome is much bigger than our genome because one gene produces several variants of proteins called protein isoforms, whose disbalance is implicated in many diseases. A new bioengineered reporter system developed at Helmholtz Zentrum München and the Technical University of Munich now allows ...

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