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New drug combination restores beta cell function in animal model

Potential for diabetes remission

24-Feb-2020

The loss of the identity of insulin-secreting beta cells in the islet of Langerhans, a process also called beta cell dedifferentiation, has been proposed to be a main reason for the development of diabetes. If and how dedifferentiated beta cells can be targeted by pharmacological intervention for ...

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Unlimited potential: New ways to generate totipotent-like cells

13-Jan-2020

Totipotency is set to become a key tool for research and future medical applications. Finding efficient ways to generate totipotent-like cells is therefore crucial. In a new study, a group of researchers at Helmholtz Zentrum München found that totipotent-like cells can be induced by manipulating ...

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Looking at the good vibes of molecules: a new method for label-free metabolic imaging

09-Jan-2020

Label-free dynamic detection of biomolecules is a major challenge in live-cell microscopy. The simultaneous visualization of dynamic alterations for classes of metabolites, such as carbohydrates and lipids, was an unmet need in biomedical research. Now, a novel imaging method developed by a ...

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New algorithm detects even the smallest cancer metastases across the entire mouse body

Exposing the enemy

16-Dec-2019

Teams at Helmholtz Zentrum München, LMU Munich and the Technical University of Munich (TUM) have developed a new algorithm that enables automated detection of metastases at the level of single disseminated cancer cells in whole mice. Cancer is one of the leading causes of death worldwide. More ...

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AI-driven single blood cell classification

New method to support physicians in leukemia diagnostics

14-Nov-2019

For the first time, researchers from Helmholtz Zentrum München and the University Hospital of LMU Munich show that deep learning algorithms perform similar to human experts when classifying blood samples from patients suffering from acute myeloid leukemia (AML). Their proof of concept study paves ...

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Pluripotency or differentiation – that is the question

07-May-2019

Induced pluripotent stem cells can turn into any type of cell in the body or remain in their original form. In the current edition of Molecular Cell, scientists from the Helmholtz Zentrum München describe how cells “decide” which of these two directions to take. During their research, they ...

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Cell atlas of the aging lung

01-Mar-2019

Aging promotes lung function decline and increases susceptibility to diseases of the respiratory tract. In order to understand these effects in detail, researchers at Helmholtz Zentrum München, a partner in the German Center for Lung Research (DZL), analyzed the aging process in the lung at ...

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Going fishing in the protein pond using histones as a bait – how do cells decide how to repair their DNA?

27-Feb-2019

When DNA in the cell nucleus gets damaged, our cells can resort to a variety of repair mechanisms. A recent study published in 'Nature Cell Biology', to which scientists from Helmholtz Zentrum München made major contributions, elucidates the molecular basis by which a cell makes the choice ...

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Call for standards of epigenetic data

02-Oct-2018

At the heart of every cell is the nucleus, which acts as the cell’s control center. Recent studies have revealed more and more information about its organization and dynamics. However, the rapid development of methods and the increasing complexity of the collected data pose major challenges. ...

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New insight into the maturation of miRNAs

04-Jul-2018

An international research team led by Helmholtz Zentrum München, Technical University of Munich and the University of Edinburgh has used an integrated structural biological approach to elucidate the maturation of a cancer-causing microRNA in gene regulation. In the future, the authors hope to ...

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