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9 Current news of IMBA
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Unraveling the genome in 3D-space
Groundbreaking method to map contact points between replicated DNA molecules, thereby elucidating how the genome is folded inside the nucleus of human cells
25-Sep-2020
The cells that make up our body are tiny, each of them measuring only micrometers in diameter. The ensemble of chromosomal DNA molecules that encode the genome, on the other hand, measures almost 2 meters. In order to fit into cells, chromosomal DNA is folded many times. But the DNA is not merely ...
A protein for the mass production of antibodies
Rare genetic defect provides fundamental knowledge about antibodies
17-Sep-2020
Scientists from the Institute of Molecular Biology of the Austrian Academy of Sciences and the University of British Columbia have discovered a major role of the protein JAGN1 in antibody production and the body’s ability to mount a defense against pathogens, including viruses. Antibodies play a ...
Scientists discover a gene to stay thin
Why some people eat as much as they want and stay lean while others can´t
25-May-2020
An international team of researchers with the participation of IMBA - Institute of Molecular Biotechnology of the Austrian Academy of Sciences – reports the discovery of a thinness gene - ALK – conserved in evolution from flies to mice and importantly in very thin humans. A noticeable impact on ...
Fighting SARS-CoV-2 in human blood vessel organoids
06-Apr-2020
SARS-CoV-2, the virus causing coronavirus disease-19 (COVID-19), is spreading worldwide at a fast pace. In a concerted effort including researchers from IMBA – Institute of Molecular Biotechnology of the Austrian Academy of Sciences – a team of international scientists produced groundbreaking ...
Upcycling of proteins protects DNA from parasites
14-Aug-2019
Researchers at IMBA - Institute for Molecular Biotechnology of the Austrian Academy of Sciences – describe “adaptive radiation” of RNA export proteins. Their findings show how a small RNA pathway utilizes and re-purposes preexisting building blocks in the cell to protect genome integrity. Of the ...
Deciphering diabetes with "game-changing" human blood vessels from stem cells
18-Jan-2019
Changes in blood vessels are the major cause of death and morbidity in diabetes. For the first time, scientists managed to grow perfect human blood vessels as organoids in a petri dish. This breakthrough engineering technology dramatically advances research of vascular dysfunction in diseases ...
Scientists characterise cancer genes using ground-breaking new method
09-Apr-2018
In a paper in the journal “Science”, researchers from the Vienna BioCenter combine cutting-edge technologies to decipher regulatory functions of important cancer genes. Key to this success is an innovative method called “SLAMseq”, which allows the direct detection of sudden changes in gene ...
Haplobank – a biobank of reversible mutant embryonic stem cells
29-Sep-2017
The Penninger lab at the IMBA developed a biobank of revertible, mutant embryonic stem cells. This cell bank – called Haplobank - contains over 100,000 mutated, conditional mouse embryonic stem cell lines, targeting about 70% of the protein-coding genome. Genetic screens have revolutionized our ...
Only lethal if sugar is present
Immunising cells against the biological weapon ricin
21-Sep-2017
The plant toxin ricin is one of the most poisonous naturally occurring proteins, making it an extremely dangerous bioweapon. Ricin attacks have made the headlines a number of times over the years, including the spectacular “umbrella murder” in London in the 1970s, or more recently the ricin ...
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