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Upcycling of proteins protects DNA from parasites

14-Aug-2019

Researchers at IMBA - Institute for Molecular Biotechnology of the Austrian Academy of Sciences – describe “adaptive radiation” of RNA export proteins. Their findings show how a small RNA pathway utilizes and re-purposes preexisting building blocks in the cell to protect genome integrity. Of the ...

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Deciphering diabetes with "game-changing" human blood vessels from stem cells

18-Jan-2019

Changes in blood vessels are the major cause of death and morbidity in diabetes. For the first time, scientists managed to grow perfect human blood vessels as organoids in a petri dish. This breakthrough engineering technology dramatically advances research of vascular dysfunction in diseases ...

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Scientists characterise cancer genes using ground-breaking new method

09-Apr-2018

In a paper in the journal “Science”, researchers from the Vienna BioCenter combine cutting-edge technologies to decipher regulatory functions of important cancer genes. Key to this success is an innovative method called “SLAMseq”, which allows the direct detection of sudden changes in gene ...

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Haplobank – a biobank of reversible mutant embryonic stem cells

29-Sep-2017

The Penninger lab at the IMBA developed a biobank of revertible, mutant embryonic stem cells. This cell bank – called Haplobank - contains over 100,000 mutated, conditional mouse embryonic stem cell lines, targeting about 70% of the protein-coding genome. Genetic screens have revolutionized our ...

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Only lethal if sugar is present

Immunising cells against the biological weapon ricin

21-Sep-2017

The plant toxin ricin is one of the most poisonous naturally occurring proteins, making it an extremely dangerous bioweapon. Ricin attacks have made the headlines a number of times over the years, including the spectacular “umbrella murder” in London in the 1970s, or more recently the ricin ...

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