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Frozen: Cutting-edge technology reveals structures within cells

05-Jan-2021

New methods enable scientists at IST Austria to take a look at the innermost of cells: high-resolution images of deep-frozen cells show structures that previously could only be guessed at. Temperatures of minus 196 degrees Celsius enable high-resolution imaging of the cell’s interior. Researchers ...

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“Off-road” mode enables mobile cells to move freely

Basic biomechanical principle of cell migration revealed

18-May-2020

Cancer cells and leukocytes are able to move through tissue and organs quickly. However, it is not fully understood how these mobile cells manage to travel and survive far away from their place of origin. In a new Nature study, the group of Michael Sixt at the Institute of Science and Technology ...

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Leukocytes use their nucleus as a ruler to choose path of least resistance

Mobile cells move around obstacles in dense tissue by selecting for larger pore sizes

05-Apr-2019

How do mobile cell types like leukocytes or metastatic cancer cells reach their place of action during immune surveillance or cancer dissemination, respectively? The research group around Michael Sixt at IST Austria has now shown that leukocytes use their nucleus as a ruler to screen their ...

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New gene potentially involved in metastasis identified

Gene named after Roman goddess Minerva as immune cells get stuck in the fruit fly’s head

28-Mar-2019

Cancers that display a specific combination of sugars, called T-antigen, are more likely to spread through the body and kill a patient. However, what regulates the appearance of T-antigen in cancer cells, the set of proteins modified with T-antigen, and the roles the T-antigen and the modified ...

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No gene is an island

Gene’s neighborhood can influence whether and how the activity of a gene changes

27-Jul-2017

Genes do not exist in isolation. Like beads on a string, they sit next to each other on long DNA molecules called chromosomes. So far, little has been known about how the position of a gene on a chromosome affects its evolution. A new study by Călin Guet, Professor at the Institute of Science and ...

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