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New methods enable scientists at IST Austria to take a look at the innermost of cells: high-resolution images of deep-frozen cells show structures that previously could only be guessed at. Temperatures of minus 196 degrees Celsius enable high-resolution imaging of the cell’s interior. Researchers ...
Basic biomechanical principle of cell migration revealed
Cancer cells and leukocytes are able to move through tissue and organs quickly. However, it is not fully understood how these mobile cells manage to travel and survive far away from their place of origin. In a new Nature study, the group of Michael Sixt at the Institute of Science and Technology ...
Mobile cells move around obstacles in dense tissue by selecting for larger pore sizes
How do mobile cell types like leukocytes or metastatic cancer cells reach their place of action during immune surveillance or cancer dissemination, respectively? The research group around Michael Sixt at IST Austria has now shown that leukocytes use their nucleus as a ruler to screen their ...
Gene named after Roman goddess Minerva as immune cells get stuck in the fruit fly’s head
Cancers that display a specific combination of sugars, called T-antigen, are more likely to spread through the body and kill a patient. However, what regulates the appearance of T-antigen in cancer cells, the set of proteins modified with T-antigen, and the roles the T-antigen and the modified ...
Gene’s neighborhood can influence whether and how the activity of a gene changes
Genes do not exist in isolation. Like beads on a string, they sit next to each other on long DNA molecules called chromosomes. So far, little has been known about how the position of a gene on a chromosome affects its evolution. A new study by Călin Guet, Professor at the Institute of Science and ...
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