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7 Current news of Leibniz-Institut für Naturstoff-Forschung und Infektionsbiologie

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Immune cells as squatters

Contrary to previous belief, some blood cells stay in tissues for years

01-Feb-2022

Human immune cells not only circulate in the blood, but can also occupy certain tissues and sometimes remain there for years. A research team led by immunologist Christina Zielinski discovered this phenomenon by examining patient samples after stem cell transplantation. In addition, the ...

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Cannabinoids from amoebae

New process for the production of active compounds

11-Jan-2022

A research team at the Leibniz Institute for Natural Product Research and Infection Biology - Hans Knöll Institute (Leibniz-HKI) in Jena, Germany has developed a new method to produce complex natural products in amoebae. These polyketides include various antibiotics but also olivetolic acid, a ...

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The pangenome - key to new therapies

Genetic diversity opens up new ways to treat life-threatening diseases

26-Nov-2021

Aspergillus fumigatus is a fungus that is widespread in the environment and causes life-threatening infections in humans. An international team of researchers has now taken a closer look at the pathogen's great genetic diversity. Serious fungal infections The fungus Aspergillus fumigatus causes ...

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Antibiotics affect balance of intestinal microbiome

Interplay between fungi and bacteria impaired

16-Sep-2020

Treatment with antibiotics has a lasting effect on the microbiome in the digestive system. While the bacterial flora is largely regenerated within 30 to 90 days after drug treatment, its interaction with resident fungi changes. In a combination of bioinformatic analyses and laboratory ...

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Tiny bodyguards

Gentle pest control in food production: Helper bacteria stop and disarm pathogens

03-Sep-2020

The bacterium Pseudomonas tolaasii triggers brown spot disease in cultivated mushrooms and thus causes considerable harvest losses. The active compound Tolaasin, which is produced by the pathogen, damages the cell membrane of the fungus and the cells die. But with some support the fungus can ...

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Cancer: Study suggests that gut microbiome can provide prognosis for therapy

Possible correlation between success of cancer therapy and intestinal microbes

26-Mar-2020

Cancer patients respond differently to therapies. The success of the classical treatment methods possibly depends on the composition of the microbiome in the gut. Study results obtained by researchers from Jena and Hong Kong point to that. For their study they investigated eight different types ...

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Synthesis of pharmaceuticals with light

06-Aug-2018

A new synthesis method in organic chemistry enables the production of numerous pharmaceuticals without the use of toxic heavy metals. Scientists from the Leibniz Institute for Natural Product Research and Infection Biology in Jena (Leibniz HKI) discovered this reaction and subsequently developed ...

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