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New marker for better assessing the severity of Covid-19

Scientists have found a new marker in the blood of Covid-19 patients. It furnishes insights into the course and development of the disease and could lead to better diagnoses

08-Dec-2021

Many people infected with SARS-CoV-2 are either asymptomatic or feel only slightly unwell. Nevertheless, the infections can produce the clinical picture of Covid-19, including inflammations and changes to blood coagulation. Moreover, doctors have observed disorders of the immune system in ...

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Previously unknown mode of bacterial growth discovered

Research teams use imaging and modelling to explain why single bacterial cells do not always grow exponentially

18-Nov-2021

Bacteria as unicellular organisms reproduce by dividing their entire organism. In this way, they can multiply particularly quickly, which allows the exponential growth of bacterial populations, also known from pathogens. The population growth is based on the growth of the individual bacterial ...

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How COVID-19 alters the immune system

COVID-19 reduces the numbers and functional competence of certain types of immune cells in the blood: This could affect responses to secondary infections

29-Oct-2021

The SARS-CoV-2 coronavirus causes moderate to severe disease in 3-10% of those infected. In such cases, the immune system overreacts to the virus, triggering an aberrant innate immune response that is characterized by systemic inflammation, intravascular blood clotting and damage to the ...

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How SARS-Coronaviruses reprogram the human cell to their own benefit

Other coronaviruses do not use this mechanism

22-Apr-2021

Coronavirus researchers under Prof. Rolf Hilgenfeld of the University of Lübeck and Dr. Albrecht von Brunn of the Ludwig-Maximilians University of Munich published a research breakthrough in the "EMBO Journal". They discovered how SARS viruses enhance the production of viral proteins in infected ...

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How cells move and don’t get stuck

New insight for developmental biology and potential cancer treatment

22-Jan-2021

Theoretical physicists from Berlin teamed up with experimental physicists from Munich to determine the precise mechanics involved in cell motility. Cell velocity, or how fast a cell moves, is known to depend on how sticky the surface is beneath it, but the precise mechanisms of this relationship ...

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Fluorescence microscopy at highest spatial and temporal resolution

Researchers simplify the MINFLUX microscope and have succeeded in differentiating molecules that are extremely close together and tracking their dynamics.

21-Jan-2021

Only a few years ago, an ostensibly fundamental resolution limit in optical microscopy was superseded - a breakthrough which in 2014 led to the Nobel Prize in Chemistry for super-resolution microscopy. Since then, there has been another quantum leap in this area, which has further reduced the ...

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Bacterial cells can tell the time

Chronobiologists report that soil bacteria possess an internal clock

14-Jan-2021

Biological processes in many organisms are known resonate with natural rhythms. For instance, it is well known that cellular functions in plants and animals are regulated by an internal ‘circadian’ clock mechanism. Circadian clocks synchronize to environmental cycles such as the natural ...

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Nanoparticles as weapons against cancer

Researchers have developed a novel type of nanoparticle that efficiently and selectively kills cancer cells, thus opening up new therapeutic options for the treatment of tumors

17-Dec-2020

Many chemotherapeutic agents used to treat cancers are associated with side-effects of varying severity, because they are toxic to normal cells as well as malignant tumors. This has motivated the search for effective alternatives to the synthetic pharmaceuticals with which most cancers are ...

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Coaxing cancer cells to commit suicide

07-Dec-2020

An LMU team has identified an enzyme that is essential for DNA repair. Loss of this factor leads to cell death when cancer cells accumulate DNA damage. Chemical inhibition of the target protein offers a possible strategy for the treatment of specific cancers. In Germany, as in most Western ...

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Photopharmacology - A light-trigger for the proteasome

A light-sensitive inhibitor can control cell division and cell death – and provides a promising approach for studies of essential cellular processes and the development of novel tumor therapies

03-Nov-2020

The ability to precisely control biological and chemical processes is an essential element of both basic research and medicine. Light represents an attractive stimulus in this context, as its effects can be accurately modulated both spatially and temporally. These desirable properties are the ...

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