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Prebiotic chemistry - In the beginning, there was sugar
Chemist reports a reaction pathway in which minerals catalyze the formation of sugars in the absence of water
22-Oct-2020
Organic molecules formed the basis for the evolution of life. But how could inorganic precursors have given rise to them? Ludwig-Maximilians-Universitaet (LMU) in Munich chemist Oliver Trapp now reports a reaction pathway in which minerals catalyze the formation of sugars in the absence of ...
How a microRNA protects vascular integrity
Hitherto unknown molecular function of a specific microRNA preserves integrity of the endothelium and reduces the risk of atherosclerosis
08-Jun-2020
Short RNA molecules known as microRNAs (miRNAs) play a vital role in the regulation of gene expression. Anomalies in miRNAs expression and function have been implicated in pathological processes, such as the development of chronic diseases like atherosclerosis. The regulatory functions of miRNAs ...
Lifting the lid on beta-barrels
02-Apr-2020
The interaction between biotin and streptavidin is a well-established experimental tool in bionanotechnology. LMU physicists have now shown that the mechanical stability of the complex is dependent on the precise geometry of the interface. Mechanical forces play a vital role at all levels in ...
Structural biology: Special delivery
05-Feb-2020
Bulky globular proteins require specialized transport systems for insertion into membranes. Ludwig-Maximilians-Universitaet (LMU) in Munich researchers have determined the structure of such a system for the first time, and propose that it exploits the principle of the airlock. Many proteins that ...
A fine sense for molecules
Unique laser technology for the analysis of the molecular composition of biological samples
07-Jan-2020
At the biochemical level, organisms can be thought of as complex collections of different species of molecules. In the course of their metabolism, biological cells synthesize chemical compounds, and modify them in multifarious ways. Many of these products are released into the intercellular ...
New algorithm detects even the smallest cancer metastases across the entire mouse body
Exposing the enemy
16-Dec-2019
Teams at Helmholtz Zentrum München, LMU Munich and the Technical University of Munich (TUM) have developed a new algorithm that enables automated detection of metastases at the level of single disseminated cancer cells in whole mice. Cancer is one of the leading causes of death worldwide. More ...
Five-fold boost in formaldehyde yield
15-Nov-2019
Environmentally benign methods for the industrial production of chemicals are urgently needed. LMU researchers recently described such a procedure for the synthesis of formaldehyde, and have now improved it with the aid of machine learning. Formaldehyde is one of the most important feedstocks ...
AI-driven single blood cell classification
New method to support physicians in leukemia diagnostics
14-Nov-2019
For the first time, researchers from Helmholtz Zentrum München and the University Hospital of LMU Munich show that deep learning algorithms perform similar to human experts when classifying blood samples from patients suffering from acute myeloid leukemia (AML). Their proof of concept study paves ...
An ultrafast glimpse of the photochemistry of the atmosphere
15-Oct-2019
Researchers at Ludwig-Maximilians-Universitaet (LMU) in Munich have explored the initial consequences of the interaction of light with molecules on the surface of nanoscopic aerosols. The nanocosmos is constantly in motion. All natural processes are ultimately determined by the interplay between ...
DNA repair: Opening the hatch to heal the break
05-Sep-2019
LMU researchers have determined the structure of a key enzyme complex that is involved in DNA repair, and traced the cycle of conformational changes that it undergoes while performing its biochemical function. Various types of DNA damage can have serious repercussions, both for the individual ...
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