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127 Current news of Max-Planck-Gesellschaftrss
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New method facilitates identification of cell-type specific genes in single-cell data
The thousands of cells in a biological sample are all different and can be analyzed individually, cell by cell. Based on their gene activity, they can be sorted into clusters. But which genes are particularly characteristic of a given cluster, i.e. what are its “marker genes”? A new statistical ...
Organoids that mimic human brain cortex in development and disease
“Outer Radial Glia” (oRG) cells are nervous system stem cells that are instrumental for the development of the human cortex and have been challenging to produce in the lab. Now, a team of Max Planck researchers from Berlin succeeded in generating brain organoids that are enriched with these stem ...
Leap in knowledge of peptide nanofibrils
Viruses help researchers to introduce genes into cells so that they can produce active pharmaceutical ingredients, for example. Special peptides stimulate the process. Until now, however, the efficiency increase was poorly understood. A team of researchers from the MPI for Polymer Research, the ...
Researchers develop a new method to simultaneously measure flow and oxygen - Accurate and fast as never before
An international research team headed by the Max Planck Institute for Marine Microbiology in Bremen, Aarhus University and the Science for Life Lab in Uppsala has developed tiny particles that measure the oxygen concentration in their surroundings. In this way, they can track fluid flow and ...
Ground-breaking technology ‘Deep Visual Proteomics’ unites four technologies
How does cancer arise? How does cellular composition influence tumor malignancy? These questions are profound and challenging to answer, but are crucial to understand the disease and find the right cure. Now, a German-Danish team led by Professor Matthias Mann has developed a ground-breaking ...
The protein complex MCM has an unexpected influence on the three-dimensional organization of DNA
The entire genomic material of a cell must be packed into a tiny cell nucleus in such a way, that on the one hand, it can be stored in an organized manner and, on the other hand, it can be transcribed, duplicated or repaired as needed. Different proteins are responsible for space-saving ...
Researchers provide a first 3D snapshot of the CCAN protein complex and raise fundamental questions towards the creation of artificial chromosomes
Human cell division involves hundreds of proteins at its core. Knowing the 3D structure of these proteins is pivotal to understand how our genetic material is duplicated and passed through generations. The groups of Andrea Musacchio and Stefan Raunser at the Max Planck Institute of Molecular ...
A large step forward in the characterization of nanoparticles: One possible application of this technique may be to identify illnesses
Scientists at the Max Planck Institute for the Science of Light (MPL) and Max-Planck-Zentrum für Physik und Medizin (MPZPM) in Erlangen present a large step forward in the characterization of nanoparticles. They used a special microscopy method based on interfereometry to outperform existing ...
Genomic studies open up a wealth of bioactive small molecules in insect-killing bacteria
Interactions between microbes and other organisms are mediated by a plethora of small molecules, also called natural products. A research team led by Dr. Yi-Ming Shi and Prof. Helge Bode from the Max Planck Institute for Terrestrial Microbiology has now performed a systematic analysis of ...
Omnipresent and yet hardly explored: Electrical synapses
They are part of the brain of almost every animal species, yet they remain usually invisible even under the electron microscope. "Electrical synapses are like the dark matter of the brain," says Alexander Borst, director at the MPI for Biological Intelligence, in foundation (i.f). Now a team from ...
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