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How to find marker genes in cell clusters

New method facilitates identification of cell-type specific genes in single-cell data

06-Jul-2022

The thousands of cells in a biological sample are all different and can be analyzed individually, cell by cell. Based on their gene activity, they can be sorted into clusters. But which genes are particularly characteristic of a given cluster, i.e. what are its “marker genes”? A new statistical ...

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Cell-culture breakthrough: Advanced “mini brains” in the dish

Organoids that mimic human brain cortex in development and disease

27-Jun-2022

“Outer Radial Glia” (oRG) cells are nervous system stem cells that are instrumental for the development of the human cortex and have been challenging to produce in the lab. Now, a team of Max Planck researchers from Berlin succeeded in generating brain organoids that are enriched with these stem ...

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Green wave for “gene cabs”

Leap in knowledge of peptide nanofibrils

03-Jun-2022

Viruses help researchers to introduce genes into cells so that they can produce active pharmaceutical ingredients, for example. Special peptides stimulate the process. Until now, however, the efficiency increase was poorly understood. A team of researchers from the MPI for Polymer Research, the ...

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Microparticles with feeling

Researchers develop a new method to simultaneously measure flow and oxygen - Accurate and fast as never before

25-May-2022

An international research team headed by the Max Planck Institute for Marine Microbiology in Bremen, Aarhus University and the Science for Life Lab in Uppsala has developed tiny particles that measure the oxygen concentration in their surroundings. In this way, they can track fluid flow and ...

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New method revolutionizes cancer diagnosis

Ground-breaking technology ‘Deep Visual Proteomics’ unites four technologies

23-May-2022

How does cancer arise? How does cellular composition influence tumor malignancy? These questions are profound and challenging to answer, but are crucial to understand the disease and find the right cure. Now, a German-Danish team led by Professor Matthias Mann has developed a ground-breaking ...

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MCM molecules impede the formation of DNA loops

The protein complex MCM has an unexpected influence on the three-dimensional organization of DNA

23-May-2022

The entire genomic material of a cell must be packed into a tiny cell nucleus in such a way, that on the one hand, it can be stored in an organized manner and, on the other hand, it can be transcribed, duplicated or repaired as needed. Different proteins are responsible for space-saving ...

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Structure of key protein for cell division puzzles researchers

Researchers provide a first 3D snapshot of the CCAN protein complex and raise fundamental questions towards the creation of artificial chromosomes

17-May-2022

Human cell division involves hundreds of proteins at its core. Knowing the 3D structure of these proteins is pivotal to understand how our genetic material is duplicated and passed through generations. The groups of Andrea Musacchio and Stefan Raunser at the Max Planck Institute of Molecular ...

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A new method for exploring the nano-world

A large step forward in the characterization of nanoparticles: One possible application of this technique may be to identify illnesses

11-May-2022

Scientists at the Max Planck Institute for the Science of Light (MPL) and Max-Planck-Zentrum für Physik und Medizin (MPZPM) in Erlangen present a large step forward in the characterization of nanoparticles. They used a special microscopy method based on interfereometry to outperform existing ...

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Finding new weapons in Nature`s battlesites

Genomic studies open up a wealth of bioactive small molecules in insect-killing bacteria

27-Apr-2022

Interactions between microbes and other organisms are mediated by a plethora of small molecules, also called natural products. A research team led by Dr. Yi-Ming Shi and Prof. Helge Bode from the Max Planck Institute for Terrestrial Microbiology has now performed a systematic analysis of ...

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The dark matter of the brain

Omnipresent and yet hardly explored: Electrical synapses

08-Apr-2022

They are part of the brain of almost every animal species, yet they remain usually invisible even under the electron microscope. "Electrical synapses are like the dark matter of the brain," says Alexander Borst, director at the MPI for Biological Intelligence, in foundation (i.f). Now a team from ...

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