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The protein complex MCM has an unexpected influence on the three-dimensional organization of DNA
The entire genomic material of a cell must be packed into a tiny cell nucleus in such a way, that on the one hand, it can be stored in an organized manner and, on the other hand, it can be transcribed, duplicated or repaired as needed. Different proteins are responsible for space-saving ...
Researchers provide a first 3D snapshot of the CCAN protein complex and raise fundamental questions towards the creation of artificial chromosomes
Human cell division involves hundreds of proteins at its core. Knowing the 3D structure of these proteins is pivotal to understand how our genetic material is duplicated and passed through generations. The groups of Andrea Musacchio and Stefan Raunser at the Max Planck Institute of Molecular ...
A large step forward in the characterization of nanoparticles: One possible application of this technique may be to identify illnesses
Scientists at the Max Planck Institute for the Science of Light (MPL) and Max-Planck-Zentrum für Physik und Medizin (MPZPM) in Erlangen present a large step forward in the characterization of nanoparticles. They used a special microscopy method based on interfereometry to outperform existing ...
Genomic studies open up a wealth of bioactive small molecules in insect-killing bacteria
Interactions between microbes and other organisms are mediated by a plethora of small molecules, also called natural products. A research team led by Dr. Yi-Ming Shi and Prof. Helge Bode from the Max Planck Institute for Terrestrial Microbiology has now performed a systematic analysis of ...
Omnipresent and yet hardly explored: Electrical synapses
They are part of the brain of almost every animal species, yet they remain usually invisible even under the electron microscope. "Electrical synapses are like the dark matter of the brain," says Alexander Borst, director at the MPI for Biological Intelligence, in foundation (i.f). Now a team from ...
Molecular morse code in stem cells encrypting differentiation information revealed
Divide, differentiate or die? Making decisions at the right time and place is what defines a cell’s behavior and is particularly critical for stem cells of an developing organisms. Decision making relies on how information is processed by networks of signaling proteins. The teams around Christian ...
How water-repellent coatings can reduce foaming in industrial processes
While foam is certainly desirable in the bathtub or on beer, preventing foam - for example in industrial processes - is a much-discussed topic. Often, oils or particles are added to liquids to prevent foaming. If these are harmful to health or the environment, they must be removed again using ...
Epigenetic mechanisms for parent-specific genetic activation decoded
Hereditary diseases as well as cancers and cardiovascular diseases may be associated with a phenomenon known as genomic imprinting, in which only the maternally or paternally inherited gene is active. An international research team involving scientists at the Technical University of Munich (TUM), ...
Neanderthal variant of the protein glutathione reductase increases risk for inflammatory bowel disease and vascular disease
Very few proteins in the body have a change that makes them unique compared to the corresponding proteins in Neanderthals and apes. Researchers at the Max Planck Institute for Evolutionary Anthropology in Germany and Karolinska Institutet in Sweden have now studied one such protein, glutathione ...
Ultrarapid cooling enables the observation of molecular patterns of life
Fluorescence light microscopy has the unique ability to observe cellular processes over a scale that bridges four orders of magnitude. Yet, its application to living cells is fundamentally limited by the very rapid and unceasing movement of molecules and the light-induced destruction of ...
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