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New method revolutionizes cancer diagnosis
Ground-breaking technology ‘Deep Visual Proteomics’ unites four technologies
23-May-2022
How does cancer arise? How does cellular composition influence tumor malignancy? These questions are profound and challenging to answer, but are crucial to understand the disease and find the right cure. Now, a German-Danish team led by Professor Matthias Mann has developed a ground-breaking ...
MCM molecules impede the formation of DNA loops
The protein complex MCM has an unexpected influence on the three-dimensional organization of DNA
23-May-2022
The entire genomic material of a cell must be packed into a tiny cell nucleus in such a way, that on the one hand, it can be stored in an organized manner and, on the other hand, it can be transcribed, duplicated or repaired as needed. Different proteins are responsible for space-saving ...
Structure of key protein for cell division puzzles researchers
Researchers provide a first 3D snapshot of the CCAN protein complex and raise fundamental questions towards the creation of artificial chromosomes
17-May-2022
Human cell division involves hundreds of proteins at its core. Knowing the 3D structure of these proteins is pivotal to understand how our genetic material is duplicated and passed through generations. The groups of Andrea Musacchio and Stefan Raunser at the Max Planck Institute of Molecular ...
A new method for exploring the nano-world
A large step forward in the characterization of nanoparticles: One possible application of this technique may be to identify illnesses
11-May-2022
Scientists at the Max Planck Institute for the Science of Light (MPL) and Max-Planck-Zentrum für Physik und Medizin (MPZPM) in Erlangen present a large step forward in the characterization of nanoparticles. They used a special microscopy method based on interfereometry to outperform existing ...
Finding new weapons in Nature`s battlesites
Genomic studies open up a wealth of bioactive small molecules in insect-killing bacteria
27-Apr-2022
Interactions between microbes and other organisms are mediated by a plethora of small molecules, also called natural products. A research team led by Dr. Yi-Ming Shi and Prof. Helge Bode from the Max Planck Institute for Terrestrial Microbiology has now performed a systematic analysis of ...
The dark matter of the brain
Omnipresent and yet hardly explored: Electrical synapses
08-Apr-2022
They are part of the brain of almost every animal species, yet they remain usually invisible even under the electron microscope. "Electrical synapses are like the dark matter of the brain," says Alexander Borst, director at the MPI for Biological Intelligence, in foundation (i.f). Now a team from ...
A new dimension in Stem Cell Signaling
Molecular morse code in stem cells encrypting differentiation information revealed
01-Mar-2022
Divide, differentiate or die? Making decisions at the right time and place is what defines a cell’s behavior and is particularly critical for stem cells of an developing organisms. Decision making relies on how information is processed by networks of signaling proteins. The teams around Christian ...
More beer in the glass with physics
How water-repellent coatings can reduce foaming in industrial processes
21-Jan-2022
While foam is certainly desirable in the bathtub or on beer, preventing foam - for example in industrial processes - is a much-discussed topic. Often, oils or particles are added to liquids to prevent foaming. If these are harmful to health or the environment, they must be removed again using ...
Unmuting the genome
Epigenetic mechanisms for parent-specific genetic activation decoded
13-Jan-2022
Hereditary diseases as well as cancers and cardiovascular diseases may be associated with a phenomenon known as genomic imprinting, in which only the maternally or paternally inherited gene is active. An international research team involving scientists at the Technical University of Munich (TUM), ...
Modern humans developed a more effective protection against oxidative stress
Neanderthal variant of the protein glutathione reductase increases risk for inflammatory bowel disease and vascular disease
07-Jan-2022
Very few proteins in the body have a change that makes them unique compared to the corresponding proteins in Neanderthals and apes. Researchers at the Max Planck Institute for Evolutionary Anthropology in Germany and Karolinska Institutet in Sweden have now studied one such protein, glutathione ...
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