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More efficient together

Proximity between identical enzymes can lead to a substantial improvement in their catalytic efficiency

17-Nov-2021

Mechanically coupled enzymes show an increase in their catalytic efficiency – this is the result from a study by the group of Ramin Golestanian and Jaime Agudo-Canalejo from the Max Planck Institute for Dynamics and Self-Organization. The researchers concluded that enzymes can benefit from ...

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Stem cells do not (only) play dice

Stem cells work as a team and do not leave their fate to pure chance

10-Nov-2021

In just a few weeks a completely new organism develops from a fertilized egg cell. The real miracle is that a bunch of identical stem cells turns into completely different, specialized cell types. A team led by Christian Schröter, group leader at the Max Planck Institute of Molecular Physiology ...

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Programming synthetic exosomes to optimize wound healing

Scientists create synthetic exosomes with natural functionalities and present their therapeutic application

08-Sep-2021

Scientists from the MPI for Medical Research and colleagues have engineered synthetic exosomes that regulate cellular signaling during wound closure. The synthetic structures resemble naturally occurring extracellular vesicles (EV) that play a fundamental role in communication between cells. The ...

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First programmable photocatalyst developed

With smart materials toward more sustainable chemistry

03-Sep-2021

Researchers at the Max Planck Institute of Colloids and Interfaces have developed a sustainable and "smart photocatalyst". The special feature: as a so-called smart material, it can distinguish between the colors of light (blue, red and green) and, in response, enables a specific chemical ...

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Molecular mechanisms of corona drug candidate Molnupiravir unraveled

Mutations in the genome stop the virus

18-Aug-2021

The United States recently secured 1.7 million doses of a compound that could help to treat Covid-19 patients. In preliminary studies, Molnupiravir reduced the transmission of the SARS-CoV-2 coronavirus. Researchers at the Max Planck Institute (MPI) for Biophysical Chemistry in Göttingen and the ...

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Cellular filaments keeping the pace

Study lays the foundation for a multitude of potential applications

11-Aug-2021

A new model describes the coordination of beating cilia allowing to predict their functional behavior. Researchers from the Max Planck Institute for Dynamics and Self-Organization (MPIDS) analyzed the formation of metachronal waves in arrays of cilia and how external cues might influence them. ...

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MaxDIA – taking proteomics to the next level

Highly sensitive and accurate data analysis: New software improves data-independent acquisition proteomics

12-Jul-2021

Proteomics produces enormous amounts of data, which can be very complex to analyze and interpret. The free software platform MaxQuant has proven to be invaluable for data analysis of shotgun proteomics over the past decade. Now, Jürgen Cox, group leader at the Max Planck Institute of ...

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Enzyme silences virus-like sequences

Methyltransferase Dnmt1 is not only responsible for maintenance

07-Jul-2021

Often, biology will not fit into clear-cut categories. In a recent publication, an enzyme to which researchers had previously assigned a distinct task is stepping outside its box. It not only maintains the epigenetic state of the genome, but can also specifically silence additional DNA segments ...

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Piecing together the full picture of the genome

Revolutionary new DNA sequencing method enables unparalleled rapid, accurate, and efficient analysis while preserving the full picture of a genome

17-Jun-2021

A team of international researchers from the Friedrich Miescher Laboratory of the Max Planck Society developed a new DNA sequencing method that provides fast and efficient tracking of genetic information. Their new technique called haplotagging now enables scientists to quickly and precisely ...

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Nucleosome breathing from atomistic time snapshots

Computer simulations visualize in atomic detail how DNA opens while wrapped around proteins

08-Jun-2021

Researchers from the Hubrecht Institute in Utrecht (The Netherlands) and the Max Planck Institute for Molecular Biomedicine in Münster (Germany) used computer simulations to reveal in atomic detail how a short piece of DNA opens while it is tightly wrapped around the proteins that package our ...

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