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Cool Microscopy: Making the invisible visible
Ultrarapid cooling enables the observation of molecular patterns of life
15-Dec-2021
Fluorescence light microscopy has the unique ability to observe cellular processes over a scale that bridges four orders of magnitude. Yet, its application to living cells is fundamentally limited by the very rapid and unceasing movement of molecules and the light-induced destruction of ...
Catch me if you can: how mRNA therapeutics are delivered into cells
Novel insights into the development of RNA therapeutics towards efficient delivery and lower dosages
13-Dec-2021
Researchers have found where and how mRNA arrives in a cell to modify or deliver genetic information, a crucial process for the development of novel therapies. In recent years, ribonucleic acid (RNA) has emerged as a powerful tool for the development of novel therapies. RNA is used to copy ...
Exploring the current paradigm of gene regulation
How much tissue-specific information is contained in enhancer sequences?
02-Dec-2021
How do cells know when to activate a certain gene? This information is encoded in the sequence of the DNA, but our understanding of this code is incomplete. Researchers now tested how much information can be extracted from sequence data to predict which gene is active in which tissue. A good ...
SARS-CoV-2 infects sustentacular cells in the olfactory epithelium of COVID-19 patients
The coronavirus does not appear to infect nerve cells in the olfactory epithelium and in the olfactory bulb
29-Nov-2021
It is now widely known that COVID-19 is associated with the transient or long-term loss of olfaction (the sense of smell) but the mechanisms remain obscure. An unresolved question is whether the olfactory nerve can provide SARS-CoV-2 with a route of entry to the brain. Scientists at the Max ...
More efficient together
Proximity between identical enzymes can lead to a substantial improvement in their catalytic efficiency
17-Nov-2021
Mechanically coupled enzymes show an increase in their catalytic efficiency – this is the result from a study by the group of Ramin Golestanian and Jaime Agudo-Canalejo from the Max Planck Institute for Dynamics and Self-Organization. The researchers concluded that enzymes can benefit from ...
Stem cells do not (only) play dice
Stem cells work as a team and do not leave their fate to pure chance
10-Nov-2021
In just a few weeks a completely new organism develops from a fertilized egg cell. The real miracle is that a bunch of identical stem cells turns into completely different, specialized cell types. A team led by Christian Schröter, group leader at the Max Planck Institute of Molecular Physiology ...
Programming synthetic exosomes to optimize wound healing
Scientists create synthetic exosomes with natural functionalities and present their therapeutic application
08-Sep-2021
Scientists from the MPI for Medical Research and colleagues have engineered synthetic exosomes that regulate cellular signaling during wound closure. The synthetic structures resemble naturally occurring extracellular vesicles (EV) that play a fundamental role in communication between cells. The ...
First programmable photocatalyst developed
With smart materials toward more sustainable chemistry
03-Sep-2021
Researchers at the Max Planck Institute of Colloids and Interfaces have developed a sustainable and "smart photocatalyst". The special feature: as a so-called smart material, it can distinguish between the colors of light (blue, red and green) and, in response, enables a specific chemical ...
Molecular mechanisms of corona drug candidate Molnupiravir unraveled
Mutations in the genome stop the virus
18-Aug-2021
The United States recently secured 1.7 million doses of a compound that could help to treat Covid-19 patients. In preliminary studies, Molnupiravir reduced the transmission of the SARS-CoV-2 coronavirus. Researchers at the Max Planck Institute (MPI) for Biophysical Chemistry in Göttingen and the ...
Cellular filaments keeping the pace
Study lays the foundation for a multitude of potential applications
11-Aug-2021
A new model describes the coordination of beating cilia allowing to predict their functional behavior. Researchers from the Max Planck Institute for Dynamics and Self-Organization (MPIDS) analyzed the formation of metachronal waves in arrays of cilia and how external cues might influence them. ...
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