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15 Current news of MDC
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COVID-19: What is driving the escalating hyperinflammation
Study published in Nature suggests novel treatment option
15-Sep-2021
The severity of COVID-19 is not determined solely by the SARS-CoV-2 virus itself; rather, it is the primary result of a dysregulated immune response. A team of researchers from Charité – Universitätsmedizin Berlin, the Max-Delbrück-Center for Molecular Medicine (MDC), Johannes Kepler University ...
Tracking RNA through space and time
Completely new avenues for studying such things as the mechanism of action of drug therapies
10-Jun-2021
A research team at the MDC has succeeded in tracking genes through space and time within a one-cell zebrafish embryo – even before cell division occurs. They have now described a method in the journal “Nature Communications” that may one day allow scientists to measure cell response to drugs, for ...
How the immune system paves the way for SARS-CoV-2
SARS-CoV-2 uses an immune system defense mechanism as a port of entry
22-Feb-2021
The immune system actually wants to fight SARS-CoV-2 with antiviral signaling molecules. But a research team from Charité and MDC has now shown how such a signaling molecule can promote the replication of the virus. Most people infected with SARS-CoV-2 are able to recover from the disease at home ...
How cells move and don’t get stuck
New insight for developmental biology and potential cancer treatment
22-Jan-2021
Theoretical physicists from Berlin teamed up with experimental physicists from Munich to determine the precise mechanics involved in cell motility. Cell velocity, or how fast a cell moves, is known to depend on how sticky the surface is beneath it, but the precise mechanisms of this relationship ...
A potent weapon against lymphomas
Mice with leukemia were cured
19-Jan-2021
MDC researchers have developed a new approach to CAR T-cell therapy. The team has shown in Nature Communications that the procedure is very effective, especially when it comes to fighting follicular lymphomas and chronic lymphocytic leukemia, the most common type of blood cancer in adults. The ...
Getting to the heart of an enzyme
Decoding the heart of NatC: X-rays help shed light on structure
10-Nov-2020
A team led by Oliver Daumke at the MDC has determined the three-dimensional structure of the NatC acetyltransferase in an article published in Nature Communications. This enzyme modifies cell proteins to enable them to perform their functions correctly. In cancer cells, however, NatC is often ...
Towards a cell-based interceptive medicine in Europe
Diagnose diseases earlier and intercept disorders before irreparable damage occurs
09-Sep-2020
Hundreds of researchers, clinicians, industry leaders and policy makers from all around Europe are united by a vision of how to revolutionize healthcare. In a perspective in Nature and the LifeTime Strategic Research Agenda they now present a roadmap of how to leverage the latest scientific ...
Enzyme prisons
A team at the MDC has answered a question that has puzzled scientists for some 40 years
28-Aug-2020
In the journal Cell, the group explains how cells are able to switch on completely different signaling pathways using only one signaling molecule: the nucleotide cAMP. To achieve this, the molecule is virtually imprisoned in nanometer-sized spaces. There are up to a hundred different receptors on ...
Likely Entrypoints for SARS-CoV-2
Two specific cell types in the nose have been identified as likely initial infection points for the novel coronavirus
24-Apr-2020
Using data from the Human Cell Atlas, scientists discovered that goblet and ciliated cells in the nose have high levels of the entry proteins that SARS-CoV-2 uses to get into our cells. The identification of these cells by researchers from the Wellcome Sanger Institute, University Medical Centre ...
Cutting off kidney cancer at its roots
19-Feb-2020
Scientists at the MDC have discovered stem cells responsible for the most common form of kidney cancer. The team of Walter Birchmeier has found a way to block the growth of these tumors in three models of the disease. Not all cancer cells are equal. Tumors contain potent cancer stem cells which ...
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