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21 Current news of MDC
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If a secretion in the lungs’ alveoli is not cleared regularly, breathing difficulties can develop.
20-Sep-2022
In a study published in Science Immunology, a team led by Alexander Mildner and Achim Leutz has now explained the pivotal role of the transcription factor C/EBPb in this process. The exchange of gases between the air we breathe and our blood takes place via alveoli – tiny air sacs in our lungs. ...
The “theft” of foreign genetic material follows a plan
31-Aug-2022
To combat pathogens, the immune system needs an enormous number of different antibodies. In an MDC study, a group led by BIH professor Kathrin de la Rosa has now described in the journal PNAS a “stealing” mechanism that contributes to antibody diversity. A few years ago, Professor Kathrin de la ...
Scientists have long regarded the cytosol liquid inside a cell as a large “swimming pool” in which everything floats around freely: But it seems that previously unknown structures
17-Mar-2022
In a study published in Cell, MDC researchers show how a cell is able to process hundreds of signals simultaneously. Andreas Bock and his colleagues believe their findings will open up a whole new field of research in cell biology. A living cell is exposed to a variety of stimuli. Countless ...
Targeted correction of genetic defects
16-Mar-2022
Mutations that lead to muscle atrophy can be repaired with the gene editor CRISPR-Cas9. A team led by ECRC researcher Helena Escobar has now introduced the tool into human muscle stem cells for the first time using mRNA, thus discovering a method suitable for therapeutic applications. It may be ...
“We've discovered three possible approaches to antiviral treatments”
15-Mar-2022
The question of how the Covid virus takes over host cells and suppresses the body's defences has been the subject of much debate. Now a research team led by Marina Chekulaeva at the MDC has pinpointed the crucial mechanism involved. It's over two years since the outbreak of the coronavirus ...
Cancer cells create protective niches for themselves
05-Nov-2021
Cellular immunotherapies have so far not been very effective against non-Hodgkin’s lymphoma. A team led by Armin Rehm of the MDC has discovered a possible reason. As they describe in “Cell Reports”, this cancer induces changes in the large blood vessels through which immune cells normally migrate ...
Study published in Nature suggests novel treatment option
15-Sep-2021
The severity of COVID-19 is not determined solely by the SARS-CoV-2 virus itself; rather, it is the primary result of a dysregulated immune response. A team of researchers from Charité – Universitätsmedizin Berlin, the Max-Delbrück-Center for Molecular Medicine (MDC), Johannes Kepler University ...
Completely new avenues for studying such things as the mechanism of action of drug therapies
10-Jun-2021
A research team at the MDC has succeeded in tracking genes through space and time within a one-cell zebrafish embryo – even before cell division occurs. They have now described a method in the journal “Nature Communications” that may one day allow scientists to measure cell response to drugs, for ...
SARS-CoV-2 uses an immune system defense mechanism as a port of entry
22-Feb-2021
The immune system actually wants to fight SARS-CoV-2 with antiviral signaling molecules. But a research team from Charité and MDC has now shown how such a signaling molecule can promote the replication of the virus. Most people infected with SARS-CoV-2 are able to recover from the disease at home ...
New insight for developmental biology and potential cancer treatment
22-Jan-2021
Theoretical physicists from Berlin teamed up with experimental physicists from Munich to determine the precise mechanics involved in cell motility. Cell velocity, or how fast a cell moves, is known to depend on how sticky the surface is beneath it, but the precise mechanisms of this relationship ...
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