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Distinct cellular receptor mutations influence the COVID-19 disease severity

This affects around 15% of the population

16-May-2022

Distinct genetic variants significantly influence an individual's immune response to the SARS-CoV-2 virus and may influence the COVID-19 disease severity. A research group led by MedUni Vienna was able to demonstrate that distinct genetic variants of the CD16a antibody receptor are associated ...

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Newly developed COVID vaccine from Austria could protect against omicron and other variants

Vaccine developed at MedUni Vienna delivers promising data

07-Apr-2022

The preclinical data for a vaccine developed at MedUni Vienna to protect against SARS-CoV-2 indicates that it is effective against all SARS-CoV-2 variants known to date, including omicron - even in those who have not yet built up any immunity as a result of vaccination (non-responders). The data ...

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Immunity to SARS-CoV-2: Spike protein docking site is Achilles' heel of the virus

This docking site does not change significantly with mutations of the virus

03-Sep-2021

Around 20% of those who have recovered from Covid-19 fail to develop immune protection against SARS-CoV-2, according to a MedUni Vienna research team led by allergologist and immunologist Rudolf Valenta from the Center for Pathophysiology, Infectiology and Immunology. Their study found that the ...

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Tracking down the tiniest of forces: how T cells detect invaders

T cells use their antigen receptors like sticky fingers - a research team was able to observe them doing so

06-May-2021

T-cells play a central role in our immune system: by means of their so-called T-cell receptors (TCR) they make out dangerous invaders or cancer cells in the body and then trigger an immune reaction. On a molecular level, this recognition process is still not sufficiently understood. Intriguing ...

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Allergic immune responses help fight bacterial infections

Exciting discovery could also explain why the body has maintained the “allergy module” throughout evolution

11-Sep-2020

Researchers from CeMM Research Center of Molecular Medicine of the Austrian Academy of Sciences, the Medical University of Vienna and Stanford University School of Medicine, have found that a module of the immune system, which is best known for causing allergic reactions, plays a key role in ...

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Drug development: Nature-derived peptides as molecular tools to study cellular signalling

19-Dec-2019

A group of researchers of the Institute of Pharmacology at the Medical University of Vienna in collaboration with the University of Vienna and different institutions in Australia, has shown that a certain peptide hormone derived from a mite activates selectively a specific secondary messenger ...

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High-fat maternal diet can cause brain damage in the unborn child

20-Nov-2019

A study team at MedUni Vienna’s Center for Brain Research has found that high-fat maternal diets can cause life-long changes in the brain of the unborn offspring. When a pregnant woman consumes a diet high in polyunsaturated omega-6 fatty acids, her body produces an excess of endogenous ...

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The lungs never forget

Specialised T-cells remember allergens

09-May-2019

According to a current study of the Medical University Vienna, specialised T memory lymphocytes in the lungs that react to inhaled allergens, cause attacks of allergic asthma. These T-helper 2-tissue resident memory cells, which are located in the lungs for a lifetime are known as Th2-TRMs, and ...

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When changing one atom makes molecules better

A method to replace hydrogen with fluorine in organic molecules makes drugs more effective

07-Mar-2019

The development and improvement of pharmaceuticals plays the central role in the ongoing battle against human disease. Organic synthesis is the field that enables these developments as it offers the toolbox to diversify chemical structures. The group of Nuno Maulide, recently named the Scientist ...

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