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8 Current news of MPI für Biochemie
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New method revolutionizes cancer diagnosis
Ground-breaking technology ‘Deep Visual Proteomics’ unites four technologies
23-May-2022
How does cancer arise? How does cellular composition influence tumor malignancy? These questions are profound and challenging to answer, but are crucial to understand the disease and find the right cure. Now, a German-Danish team led by Professor Matthias Mann has developed a ground-breaking ...
MCM molecules impede the formation of DNA loops
The protein complex MCM has an unexpected influence on the three-dimensional organization of DNA
23-May-2022
The entire genomic material of a cell must be packed into a tiny cell nucleus in such a way, that on the one hand, it can be stored in an organized manner and, on the other hand, it can be transcribed, duplicated or repaired as needed. Different proteins are responsible for space-saving ...
MaxDIA – taking proteomics to the next level
Highly sensitive and accurate data analysis: New software improves data-independent acquisition proteomics
12-Jul-2021
Proteomics produces enormous amounts of data, which can be very complex to analyze and interpret. The free software platform MaxQuant has proven to be invaluable for data analysis of shotgun proteomics over the past decade. Now, Jürgen Cox, group leader at the Max Planck Institute of ...
Biological machine produces its own building blocks
Researchers have for the first time developed a genome the size of a minimal cell that can copy itself
18-Feb-2020
The field of synthetic biology does not only observe and describe processes of life but also mimics them. A key characteristic of life is the ability to ability for replication, which means the maintenance of a chemical system. Scientists at the Max Planck Institute of Biochemistry in Martinsried ...
In the right place at the right time
Scientists decipher the activation chain of protein degradation
17-Feb-2020
Proteins are molecular work horses in the cell that perform specific tasks, but it is essential that the timing of protein activities is exquisitely controlled. When proteins have fulfilled their tasks, degradation of these proteins will end processes that are unneeded or detrimental. To control ...
Decoding the structure of huntingtin
Determining the three dimensional structure of the protein could help to develop new treatments of Huntington's disease
23-Feb-2018
Mutations on a single gene, the huntingtin gene, are the cause of Huntington's disease. They lead to an incorrect form of the correspondent protein. With the help of cryo-electron microscopy researchers from the Max Planck Institute of Biochemistry in Martinsried and Ulm University have now ...
Cellular power outage
Quality control in the mitochondria
01-Nov-2017
A common feature of neurodegenerative diseases such as Alzheimer's, Parkinson's or Huntington's disease are deposits of aggregated proteins in the patient's cells that cause damage to cellular functions. Scientists report that, even in normal cells, aberrant aggregation-prone proteins are ...
A social network of human proteins
Complex life is only possible because proteins bind to each other, forming higher-order structures and signal pathways
23-Oct-2015
Scientists at the Max Planck Institute of Biochemistry in Martinsried near Munich and at the MPI of Molecular Cell Biology and Genetics in Dresden have now drawn a detailed map of human protein interactions. Using a novel mass spectrometric quantification method, the researchers determined the ...
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