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Molecular mechanisms of corona drug candidate Molnupiravir unraveled

Mutations in the genome stop the virus

18-Aug-2021

The United States recently secured 1.7 million doses of a compound that could help to treat Covid-19 patients. In preliminary studies, Molnupiravir reduced the transmission of the SARS-CoV-2 coronavirus. Researchers at the Max Planck Institute (MPI) for Biophysical Chemistry in Göttingen and the ...

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New microscopy method resolves fluorescent molecules with resolution at the nanometer scale

22-Mar-2021

Scientists working with Stefan Hell at the Max Planck Institute (MPI) for Biophysical Chemistry in Göttingen and the Heidelberg-based MPI for Medical Research have developed another light microscopy method, called MINSTED, which resolves fluorescently labeled details with molecular sharpness. ...

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Crystal structures in super slow motion

Researchers first to succeed in filming a phase transition with extremely high spatial and temporal resolution

26-Jan-2021

Laser beams can be used to change the properties of materials in an extremely precise way. This principle is already widely used in technologies such as rewritable DVDs. However, the underlying processes generally take place at such unimaginably fast speeds and at such a small scale that they ...

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World record resolution in cryo-electron microscopy

Novel technique visualizes individual atoms in a protein with cryo-electron microscopy for the first time

23-Oct-2020

A crucial resolution barrier in cryo-electron microscopy has been broken. Holger Stark and his team at the Max Planck Institute (MPI) for Biophysical Chemistry have observed single atoms in a protein structure for the first time and taken the sharpest images ever with this method. Such ...

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Virus multiplication in 3D

16-Dec-2019

Vaccinia viruses serve as a vaccine against human smallpox and as the basis of new cancer therapies. Two studies now provide fascinating insights into their unusual propagation strategy at the atomic level. For viruses to multiply, they usually need the support of the cells they infect. In many ...

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Stickier than expected: Hydrogen binds to graphene in 10 femtoseconds

07-May-2019

Graphene is celebrated as an extraordinary material. It consists of pure carbon, only a single atomic layer thick. Nevertheless, it is extremely stable, strong, and even conductive. For electronics, however, graphene still has crucial disadvantages. It cannot be used as a semiconductor, since it ...

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Tailor drugs for new targets in cancer therapy

Like a wedge in a hinge

16-Apr-2018

In the fight against cancer, scientists are developing new drugs to hit tumor cells at so far unused weak points. Such a “sore spot” is the protein complex SF3B. Researchers led by Vlad Pena at the Max Planck Institute (MPI) for Biophysical Chemistry in Göttingen have now succeeded for the first ...

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Watching Molecular Machines at Work

15-Aug-2016

An international team of scientists from Austria, Germany and the US has combined newly developed techniques in electron microscopy and protein assembly to elucidate how cells regulate one of the most important steps in cell division. When one cell divides into two - that is how all forms of life ...

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Detailed structure of cell’s garbage disposal unit reveals surprise in how it is targeted by cancer drugs

Every atom counts

08-Aug-2016

Malignant cancer cells not only proliferate faster than most healthy cells in our bodies. They also generate more “junk”, such as faulty and damaged proteins. This makes cancer cells inherently more dependent on the most important cellular garbage disposal unit, the proteasome, which degrades ...

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