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10 Current news of MPI für Infektionsbiologierss
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Researchers reveal transformation of colon organoids in vitro
Escherichia coli bacteria are constitutive members of the human gut microbiota. However, some strains produce a genotoxin called colibactin, which is implicated in the development of colorectal cancer. While it has been shown that colibactin leaves very specific changes in the DNA of host cells ...
Scientists identify mutations in the genome caused by the intestinal bacterium Escherichia coli
Some bacterial pathogens cause damage in the genomes of their infected cells which could lead to the initiation of cancer. While it is difficult to link an infection with an onset of cancer that arises many years later in life, researchers have been looking for definitive proof that such links ...
Researchers are using organ-like cell cultures to investigate compounds to combat the new virus
Before new drugs can be administered to people, researchers first have to investigate their effects using cell cultures and animal testing. Human cell cultures are increasingly being used as a model system for this purpose. At the Max Planck Institute for Infection Biology in Berlin, a research ...
In Germany, a vaccine candidate will be tested for its effectiveness against infections with SARS-CoV-2
The course of the corona pandemic will strongly depend on how quickly medications or vaccines against the SARS co-virus 2 can be developed. In at least one Phase III study, researchers want to investigate whether the vaccine candidate VPM1002, originally developed against tuberculosis by ...
Immune cells can be the body's defenders and foes at the same time
Malaria is one of the world's deadliest infectious diseases: a small mosquito bite delivers numerous malaria parasites into the bloodstream. The human body defends itself valiantly against the parasite, which usually results in periodic flu-like symptoms and severe fever. Severe cases of the ...
A subpopulation of stem cells releases antimicrobial peptides to defend the gastric mucosa against pathogenic bacteria
Our mucosal surfaces are constantly exposed to numerous bacterial species, some of which can induce DNA damage in host cells. Normally this remains inconsequential, as the rapid turnover of the mucosa means damaged cells are shed within days. However, if the long-lived stem cells that continually ...
The relative frequency of two mosquito species determines the risk of transmission to humans
Mosquitoes transmit malaria, but not every malaria-infected mosquito is the same. An international team led by Elena Levashina from the Max Planck Institute for Infection Biology in Berlin has described in a new publication that some species of mosquitoes are better in transmitting Plasmodium ...
Researchers discover how bacteria could promote inflammation and the development of ovarian cancer
For a long time, researchers were only able to examine human cells infected with bacteria by using cancer cell lines. However, these transformed cells often give a false impression of the infection process. Fallopian tube organoids from normal human fallopian tube cells, on the other hand, ...
By extracting cholesterol from host cell membranes, Helicobacter pylori generates “micro-islands”
The gastric bacterium H. pylori colonizes the stomachs of around half the human population and can lead to the development of gastric cancer. It is usually acquired in childhood and persists life-long, despite a strong inflammatory defence reaction in the gastric mucosa. Such inflammation is ...
Biomarkers may be able to predict the risk of developing tuberculosis in future
Together with AIDS, tuberculosis ranks among those infectious diseases with the highest global mortality rate, claiming the lives of between 1.5 and two million people every year. However, not everyone infected with the bacterium develops tuberculosis. In fact, fewer than ten percent of those ...
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