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Making Puffer Fish Toxin in a Flask

Total synthesis of tetrodotoxin

10-Mar-2020

In Japan, puffer fish is considered a delicacy, but the tickle to the taste buds comes with a tickle to the nerves: fugu contains tetrodotoxin, a strong nerve toxin. In low doses, tetrodotoxin is shown in clinical trials to be a replacement for opioids for relieving cancer related pain. In the ...

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Water-Soluble Warped Nanographene

Synthesis of a water-soluble warped nanographene and its application for photo-induced cell death

13-Feb-2018

Graphene and its nano-sized little sibling, nanographene, are well known for their remarkable photoelectronic properties. However, biomedical applications are hampered by the insolubility of the materials, especially in water. A Japanese team of scientists has now introduced substituted “warped ...

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2-D tin (stanene) without buckling

A possible topological insulator

23-Jan-2018

Nagoya University-led researchers produce 2D sheets of tin atoms predicted to have exotic uses in electronics. Nagoya, Japan - Sometimes it pays to be two-dimensional. The merits of graphene, a 2D sheet of carbon atoms, are well established. In its wake have followed a host of "post-graphene ...

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Breaking down plastic waste

Organo-ruthenium mediated hydrogenation under mild conditions

30-May-2017

What to do proteins and Kevlar have in common? Both feature long chain molecules that are strung together by amide bonds. These strong chemical bonds are also common to many other naturally occurring molecules as well as man-made pharmaceuticals and plastics. Although amide bonds can give great ...

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Rapid synthesis towards optically active alpha-aminocarbonyl therapeutics

New catalytic asymmetric reaction directly installs amines into carbonyl compounds

24-Nov-2016

A team of organic chemists at ITbM, Nagoya University, has developed a new reaction to directly install amines into carbonyl compounds using their unique phase-transfer catalyst. This unprecedented method leads to the rapid formation of optically active (chiral) α-aminocarbonyls, which are ...

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