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Making the Invisible Visible – Two-Step Mechanism Discovered that Enables Innate Immune System to Detect Viruses Like HIV Early

Understanding this mechanism could be helpful for the development of AIDS vaccines


Researchers at the Paul-Ehrlich-Institut participating in an international research network have discovered a two-step mechanism of the innate immune system that also makes it possible to specifically recognise HIV (human immunodeficiency virus) and trigger an early immune response. This ...


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Antibodies from COVID-19-Vaccinated Recognise Different SpikeProtein Structures than Antibodies from Convalescents


Some COVID-19 vaccines use a modified (stabilised) variant of the Coronavirus SARS-CoV-2 spike protein as a target antigen structure. In SARS-CoV-2 infections, the immune system recognises the unmodified form of the spike protein as an antigen. Researchers at the Paul-Ehrlich-Institut were able ...


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Innate Immune System is Barely the Driver of Excessive Immune Reactions in COVID-19


Serious courses of COVID-19 disease are concurrent with an immune system that went out of control, whereby major amounts of immunological messengers are released. Contrary to previous assumptions, immune cells from the innate immune response obviously do not play a relevant role in these ...


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Tissue damage through cell fusion in COVID-19 and the role of the spike protein

Promising assays of how to measure these membrane functions


The Coronavirus SARS-CoV-2 enters human cells by membrane fusion after contact of its spike protein with the ACE2 receptor. New studies provide proof for a second role of the protein in COVID-19: Fusion of body cells. A research team of the Paul-Ehrlich-Institut has developed promising assays of ...


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COVID-19: How is Severity of the Disease Related to Antibody Response?


Researchers from the Paul-Ehrlich-Institut jointly with teams of the University Hospital at Frankfurt/Main and the Leibniz Institute for Primate Research (Leibniz-Instituts für Primatenforschung) at Göttingen have studied the antibody response of COVID-19 patients in Germany. The aim was to gain ...


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New Vaccine Platform for a Vaccination against Hepatitis B

Oral or Transdermal Vaccination Possible


Scientists of the Paul-Ehrlich-Institut have researched a vaccine platform, which confers a very good immune response (B cell and T cell response) and protection against hepatitis B in the mouse model. The vaccine platform is based on virus-like particles (VLPs) of the hepatitis B virus. The VLPs ...


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Approved medications – new role in combating infections?


Influenza A viruses periodically cause severe influenza epidemics. Due to their genetic variability, new subtypes can emerge that are no longer covered by seasonal influenza vaccines. Looking for an effective treatment of such serious influenza infections, researchers of the Paul-Ehrlich-Institut ...


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Machine Learning to increase biotechnology-based protein production


In a research co-operation, researchers of the Paul-Ehrlich-Institut (PEI) have developed a mathematical model which allows more accurate forecasts and improved output in the biotechnology-based protein synthesis in host organism. The new method offers many and varied applications in ...


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Important host protein revealed for measles, mumps, and HRSV infections


One approach in developing new medicines to treat virus infections is to search for components of the host cell which viruses require to enter the cell and replicate. In an international research collaboration, scientists at the Paul-Ehrlich-Institut discovered that ABCE1, a member of the ABC ...


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Raman spectroscopy allows fast analysis of vaccines


Vaccines are complex biomedicines composed of a number of different molecules. In the manufacturing process and before marketing authorisation, extensive research is required to verify the identity, quality, efficacy and safety of the products. Fast, cost-effective yet reliable analytical methods ...


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