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11 Current news of Paul-Ehrlich-Institutrss
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Understanding this mechanism could be helpful for the development of AIDS vaccines
Researchers at the Paul-Ehrlich-Institut participating in an international research network have discovered a two-step mechanism of the innate immune system that also makes it possible to specifically recognise HIV (human immunodeficiency virus) and trigger an early immune response. This ...
Some COVID-19 vaccines use a modified (stabilised) variant of the Coronavirus SARS-CoV-2 spike protein as a target antigen structure. In SARS-CoV-2 infections, the immune system recognises the unmodified form of the spike protein as an antigen. Researchers at the Paul-Ehrlich-Institut were able ...
Serious courses of COVID-19 disease are concurrent with an immune system that went out of control, whereby major amounts of immunological messengers are released. Contrary to previous assumptions, immune cells from the innate immune response obviously do not play a relevant role in these ...
Promising assays of how to measure these membrane functions
The Coronavirus SARS-CoV-2 enters human cells by membrane fusion after contact of its spike protein with the ACE2 receptor. New studies provide proof for a second role of the protein in COVID-19: Fusion of body cells. A research team of the Paul-Ehrlich-Institut has developed promising assays of ...
Researchers from the Paul-Ehrlich-Institut jointly with teams of the University Hospital at Frankfurt/Main and the Leibniz Institute for Primate Research (Leibniz-Instituts für Primatenforschung) at Göttingen have studied the antibody response of COVID-19 patients in Germany. The aim was to gain ...
Oral or Transdermal Vaccination Possible
Scientists of the Paul-Ehrlich-Institut have researched a vaccine platform, which confers a very good immune response (B cell and T cell response) and protection against hepatitis B in the mouse model. The vaccine platform is based on virus-like particles (VLPs) of the hepatitis B virus. The VLPs ...
Influenza A viruses periodically cause severe influenza epidemics. Due to their genetic variability, new subtypes can emerge that are no longer covered by seasonal influenza vaccines. Looking for an effective treatment of such serious influenza infections, researchers of the Paul-Ehrlich-Institut ...
In a research co-operation, researchers of the Paul-Ehrlich-Institut (PEI) have developed a mathematical model which allows more accurate forecasts and improved output in the biotechnology-based protein synthesis in host organism. The new method offers many and varied applications in ...
One approach in developing new medicines to treat virus infections is to search for components of the host cell which viruses require to enter the cell and replicate. In an international research collaboration, scientists at the Paul-Ehrlich-Institut discovered that ABCE1, a member of the ABC ...
Vaccines are complex biomedicines composed of a number of different molecules. In the manufacturing process and before marketing authorisation, extensive research is required to verify the identity, quality, efficacy and safety of the products. Fast, cost-effective yet reliable analytical methods ...
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