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The Cut and Restore Protein Trick: Self-Excising Designer Proteins Report Isoform Expression

07-Jun-2021

Our proteome is much bigger than our genome because one gene produces several variants of proteins called protein isoforms, whose disbalance is implicated in many diseases. A new bioengineered reporter system developed at Helmholtz Zentrum München and the Technical University of Munich now allows ...

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Enzyme system for the hydrogen industry

Platinum-free biocatalyst for fuel cells and water electrolysis

14-May-2021

An enzyme could make a dream come true for the energy industry: It can efficiently produce hydrogen using electricity and can also generate electricity from hydrogen. The enzyme is protected by embedding it in a polymer. An international research team with significant participation of scientists ...

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Artificial intelligence deciphers genetic instructions

Deep learning algorithms reveal the rules of gene regulation

22-Feb-2021

With the help of artificial intelligence (AI) a German-American team of scientists deciphered some of the more elusive instructions encoded in DNA. Their neural network trained on high-resolution maps of protein-DNA interactions uncovers subtle DNA sequence patterns throughout the genome, thus ...

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Synthetic “mini” receptors block atherosclerosis

New synthetic peptides could attenuate atherosclerosis

15-Feb-2021

Atherosclerosis, a lipid-triggered chronic inflammatory disease of our arteries, is the main cause of strokes and heart attacks. An international team of researchers led by the Technical University of Munich (TUM) and the LMU University Hospital has developed novel synthetic peptides that can ...

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3D images display plant organs down to the smallest detail

Intelligent software for a better understanding of plant tissue development

01-Oct-2020

Using artificial intelligence, researchers have developed a novel computer-based image processing method for plant sciences. The method enables the detailed 3D representation of all cells in various plant organs with unprecedented precision. Plant organs, such as the root, the shoot axis, the ...

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Secure nano-carrier delivers medications directly to cells

Nanoparticles with synthetic DNA can control release of drugs

30-Sep-2020

Medications often have unwanted side-effects. One reason is that they reach not only the unhealthy cells for which they are intended, but also reach and have an impact on healthy cells. Researchers at the Technical University of Munich (TUM), working together with the KTH Royal Institute of ...

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In the hunt for new treatments against the coronavirus

Software for drug repurposing: Systems medicine and artificial intelligence for data analysis

28-Apr-2020

Currently, the corona pandemic is dominating the entire social life in Germany and in many other parts of the world. We are working flat out in order to better help the more than one hundred thousand seriously ill people in hospitals. One promising approach to extending current treatment methods ...

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Benzene in cherry flavor - where it comes from and how to avoid it?

Flavorings containing benzaldehyde can develop benzene under the influence of light

30-Mar-2020

In 2013, the Stiftung Warentest found harmful benzene in drinks with cherry flavor. But how did the substance get into the drinks? Was the source benzaldehyde, an essential component of the cherry flavoring? And if so, how could the problem be solved? A new study by the Leibniz-Institute for Food ...

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Blocking sugar structures on viruses and tumor cells

Artificial sugar-binding protein may inhibit cell growth

19-Mar-2020

During a viral infection, viruses enter the body and multiply in its cells. Viruses often specifically attach themselves to the sugar structures of the host cells, or present characteristic sugar structures on their surface themselves. Researchers at the Technical University of Munich (TUM) have ...

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Safe from over- or underdosing

Long-lasting and precise dosing of medication thanks to an oil-hydrogel mixture

24-Feb-2020

Using a mixture of oil droplets and hydrogel, medical active agents can be not only precisely dosed, but also continuously administered over periods of up to several days. The active agents inside the active droplets are released at a constant rate, decreasing the risk of over- or ...

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