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Cancer: Inactive receptor renders immunotherapies ineffective

Important reason for poor response to checkpoint inhibitors identified

16-Oct-2019

The aim of immunotherapies is to enable the immune system once again to fight cancer on its own. Drugs known as checkpoint inhibitors are already in clinical use for this purpose. However, they are only effective in about one third of patients. Based on analysis of human tissue samples, a team ...

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ClpX-ClpP protein complex could be starting point for new antibiotics

Weak spot in pathogenic bacteria

08-Oct-2019

Antibiotics are still the most important weapon for combatting bacterial infections. But medical science is running out of “ammunition” because of more and more frequently occurring resistances. A research team has now elucidated the structure of the proteolytic complex ClpX-ClpP. This is a key ...

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Light in the nanoworld

Quantum light sources pave the way for optical circuits

06-Aug-2019

An international team headed up by Alexander Holleitner and Jonathan Finley, physicists at the Technical University of Munich (TUM), has succeeded in placing light sources in atomically thin material layers with an accuracy of just a few nanometers. The new method allows for a multitude of ...

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Activity of fuel cell catalysts doubled

Modelling leads to the optimum size for platinum fuel cell catalysts

04-Jul-2019

An interdisciplinary research team at the Technical University of Munich (TUM) has built platinum nanoparticles for catalysis in fuel cells: The new size-optimized catalysts are twice as good as the best process commercially available today. Fuel cells may well replace batteries as the power ...

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Tox "exhausts" immune cells

Molecular switch for reduced immune cell function discovered

19-Jun-2019

Tumors and certain viral infections pose a challenge to the human body which the immune system typically fails to hand. In these diseases it switches to hypofunctional state that prevent adequate protection. A research team from the Technical University of Munich (TUM) has achieved a major ...

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Efficient catalyst for water splitting

New hybrid semiconductor material for sustainable hydrogen production

20-May-2019

Chemists at the Technical University of Munich (TUM) have developed an efficient water splitting catalyst as part of a collaborative international research effort. The catalyst comprises a double-helix semiconductor structure encased in carbon nitride. It is perfect for producing hydrogen ...

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How plants defend themselves

Plant immune system detects bacteria through small fatty acid molecules

16-Apr-2019

Like humans and animals, plants defend themselves against pathogens with the help of their immune system. But how do they activate their cellular defenses? Researchers at the Technical University of Munich (TUM) have now discovered that receptors in plant cells identify bacteria through simple ...

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Black nanoparticles slow the growth of tumors

Melanin as a new diagnosis and treatment tool for tumors

08-Apr-2019

The dark skin pigment melanin protects us from the sun’s damaging rays by absorbing light energy and converting it to heat. This could make it a very effective tool in tumor diagnosis and treatment, as demonstrated by a team from the Technical University of Munich (TUM) and Helmholtz Zentrum ...

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Labeling proteins with ubiquitin paves new road to cell regulation research

Tipping the scales

04-Apr-2019

Human cells have a sophisticated regulatory system at their disposal: labeling proteins with the small molecule ubiquitin. In a first, a team from the Technical University of Munich (TUM) has succeeded in marking proteins with ubiquitin in a targeted manner, in test tubes as well as in living ...

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New approach facilitates spectroscopy on individual molecules

At the limits of detectability

08-Mar-2019

While spectroscopic measurements are normally averaged over myriad molecules, a new method developed by researchers at the Technical University of Munich (TUM) provides precise information about the interaction of individual molecules with their environment. This will accelerate the ...

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