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Productive Cascade

Total synthesis of the sesquiterpene agarozizanol B

12-Oct-2021

Starting from available chemicals, a German team of researchers successfully completed the total synthesis of agarozizanol B, an interesting natural substance found in agarwood. As described in the journal Angewandte Chemie, the key sequence in the relatively short synthetic pathway is a ...

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Machine learning assisted structure analysis reveals SARS-CoV-2 virus tactics

The proteins of Covid-19

17-Sep-2021

The proteins of SARS-CoV-2 play key roles in how the virus manages to evade immune defense and replicate itself in patients’ cells. An international research team – with significant contribution from the Technical University of Munich (TUM) – has now compiled the most detailed view of the virus' ...

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New approach identifies T cells in Covid-19 patients

Immune cell profile reveals appearance, number and activity level against SARS-CoV-2

20-Aug-2021

T cells play a decisive role in fighting the coronavirus and preventing infected individuals from becoming seriously ill. They identify and fight the virus directly within the infected cells. A team of researchers working in Munich have produced a precise profile of the T cells that respond to ...

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The virus trap

Hollow nano-objects made of DNA could trap viruses and render them harmless

16-Jul-2021

To date, there are no effective antidotes against most virus infections. An interdisciplinary research team at the Technical University of Munich (TUM) has now developed a new approach: they engulf and neutralize viruses with nano-capsules tailored from genetic material using the DNA origami ...

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Versatile and reliable SARS-CoV-2 antibody assay

Automated microarray rapid test for detecting SARS-CoV-2 antibodies

28-Jun-2021

During the continued progression of the Corona pandemic, rapid, inexpensive, and reliable tests will become increasingly important to determine whether people have the associated antibodies – either through infection or vaccination. Researchers at the Technical University of Munich (TUM) have now ...

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The Cut and Restore Protein Trick: Self-Excising Designer Proteins Report Isoform Expression

07-Jun-2021

Our proteome is much bigger than our genome because one gene produces several variants of proteins called protein isoforms, whose disbalance is implicated in many diseases. A new bioengineered reporter system developed at Helmholtz Zentrum München and the Technical University of Munich now allows ...

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Enzyme system for the hydrogen industry

Platinum-free biocatalyst for fuel cells and water electrolysis

14-May-2021

An enzyme could make a dream come true for the energy industry: It can efficiently produce hydrogen using electricity and can also generate electricity from hydrogen. The enzyme is protected by embedding it in a polymer. An international research team with significant participation of scientists ...

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Artificial intelligence deciphers genetic instructions

Deep learning algorithms reveal the rules of gene regulation

22-Feb-2021

With the help of artificial intelligence (AI) a German-American team of scientists deciphered some of the more elusive instructions encoded in DNA. Their neural network trained on high-resolution maps of protein-DNA interactions uncovers subtle DNA sequence patterns throughout the genome, thus ...

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Synthetic “mini” receptors block atherosclerosis

New synthetic peptides could attenuate atherosclerosis

15-Feb-2021

Atherosclerosis, a lipid-triggered chronic inflammatory disease of our arteries, is the main cause of strokes and heart attacks. An international team of researchers led by the Technical University of Munich (TUM) and the LMU University Hospital has developed novel synthetic peptides that can ...

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3D images display plant organs down to the smallest detail

Intelligent software for a better understanding of plant tissue development

01-Oct-2020

Using artificial intelligence, researchers have developed a novel computer-based image processing method for plant sciences. The method enables the detailed 3D representation of all cells in various plant organs with unprecedented precision. Plant organs, such as the root, the shoot axis, the ...

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