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COVID-19: Breakthrough infection can substitute for a third vaccine shot

According to the study, this is possible in three constellations

03-Feb-2022

According to a new study led by Ulrike Protzer, a breakthrough infection after two vaccinations achieves the same protective effect as an additional booster vaccination. According to the study by Helmholtz Munich, LMU and TUM, the decisive factor for immunity is that the immune system has had ...

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Unmuting the genome

Epigenetic mechanisms for parent-specific genetic activation decoded

13-Jan-2022

Hereditary diseases as well as cancers and cardiovascular diseases may be associated with a phenomenon known as genomic imprinting, in which only the maternally or paternally inherited gene is active. An international research team involving scientists at the Technical University of Munich (TUM), ...

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Optimization of mRNA containing nanoparticles

Investigations at FRM II aid in the development of mRNA medications

04-Jan-2022

The research neutron source Hein Maier-Leibnitz (FRM II) at the Technical University of Munich (TUM) is playing an important role in the investigation of mRNA nanoparticles similar to the ones used in the Covid-19 vaccines from vendors BioNTech and Pfizer. Researchers at the Heinz Maier-Leibnitz ...

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Machine learning deployed to fast-track industrial optimization process

Minimization of defects in ALD passivation films with only two steps through Bayesian optimization

16-Dec-2021

An interdisciplinary team of researchers at the Max Planck Institute for Intelligent Systems, the Max Planck Institute for Solid State Research, the Technical University of Munich, and Robert Bosch GmbH deploy Bayesian Machine Learning methods to fast-track the optimization process of coating ...

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Productive Cascade

Total synthesis of the sesquiterpene agarozizanol B

12-Oct-2021

Starting from available chemicals, a German team of researchers successfully completed the total synthesis of agarozizanol B, an interesting natural substance found in agarwood. As described in the journal Angewandte Chemie, the key sequence in the relatively short synthetic pathway is a ...

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Machine learning assisted structure analysis reveals SARS-CoV-2 virus tactics

The proteins of Covid-19

17-Sep-2021

The proteins of SARS-CoV-2 play key roles in how the virus manages to evade immune defense and replicate itself in patients’ cells. An international research team – with significant contribution from the Technical University of Munich (TUM) – has now compiled the most detailed view of the virus' ...

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New approach identifies T cells in Covid-19 patients

Immune cell profile reveals appearance, number and activity level against SARS-CoV-2

20-Aug-2021

T cells play a decisive role in fighting the coronavirus and preventing infected individuals from becoming seriously ill. They identify and fight the virus directly within the infected cells. A team of researchers working in Munich have produced a precise profile of the T cells that respond to ...

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The virus trap

Hollow nano-objects made of DNA could trap viruses and render them harmless

16-Jul-2021

To date, there are no effective antidotes against most virus infections. An interdisciplinary research team at the Technical University of Munich (TUM) has now developed a new approach: they engulf and neutralize viruses with nano-capsules tailored from genetic material using the DNA origami ...

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Versatile and reliable SARS-CoV-2 antibody assay

Automated microarray rapid test for detecting SARS-CoV-2 antibodies

28-Jun-2021

During the continued progression of the Corona pandemic, rapid, inexpensive, and reliable tests will become increasingly important to determine whether people have the associated antibodies – either through infection or vaccination. Researchers at the Technical University of Munich (TUM) have now ...

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The Cut and Restore Protein Trick: Self-Excising Designer Proteins Report Isoform Expression

07-Jun-2021

Our proteome is much bigger than our genome because one gene produces several variants of proteins called protein isoforms, whose disbalance is implicated in many diseases. A new bioengineered reporter system developed at Helmholtz Zentrum München and the Technical University of Munich now allows ...

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