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COVID-19: Breakthrough infection can substitute for a third vaccine shot
According to the study, this is possible in three constellations
03-Feb-2022
According to a new study led by Ulrike Protzer, a breakthrough infection after two vaccinations achieves the same protective effect as an additional booster vaccination. According to the study by Helmholtz Munich, LMU and TUM, the decisive factor for immunity is that the immune system has had ...
Unmuting the genome
Epigenetic mechanisms for parent-specific genetic activation decoded
13-Jan-2022
Hereditary diseases as well as cancers and cardiovascular diseases may be associated with a phenomenon known as genomic imprinting, in which only the maternally or paternally inherited gene is active. An international research team involving scientists at the Technical University of Munich (TUM), ...
Optimization of mRNA containing nanoparticles
Investigations at FRM II aid in the development of mRNA medications
04-Jan-2022
The research neutron source Hein Maier-Leibnitz (FRM II) at the Technical University of Munich (TUM) is playing an important role in the investigation of mRNA nanoparticles similar to the ones used in the Covid-19 vaccines from vendors BioNTech and Pfizer. Researchers at the Heinz Maier-Leibnitz ...
Machine learning deployed to fast-track industrial optimization process
Minimization of defects in ALD passivation films with only two steps through Bayesian optimization
16-Dec-2021
An interdisciplinary team of researchers at the Max Planck Institute for Intelligent Systems, the Max Planck Institute for Solid State Research, the Technical University of Munich, and Robert Bosch GmbH deploy Bayesian Machine Learning methods to fast-track the optimization process of coating ...
Productive Cascade
Total synthesis of the sesquiterpene agarozizanol B
12-Oct-2021
Starting from available chemicals, a German team of researchers successfully completed the total synthesis of agarozizanol B, an interesting natural substance found in agarwood. As described in the journal Angewandte Chemie, the key sequence in the relatively short synthetic pathway is a ...
Machine learning assisted structure analysis reveals SARS-CoV-2 virus tactics
The proteins of Covid-19
17-Sep-2021
The proteins of SARS-CoV-2 play key roles in how the virus manages to evade immune defense and replicate itself in patients’ cells. An international research team – with significant contribution from the Technical University of Munich (TUM) – has now compiled the most detailed view of the virus' ...
New approach identifies T cells in Covid-19 patients
Immune cell profile reveals appearance, number and activity level against SARS-CoV-2
20-Aug-2021
T cells play a decisive role in fighting the coronavirus and preventing infected individuals from becoming seriously ill. They identify and fight the virus directly within the infected cells. A team of researchers working in Munich have produced a precise profile of the T cells that respond to ...
The virus trap
Hollow nano-objects made of DNA could trap viruses and render them harmless
16-Jul-2021
To date, there are no effective antidotes against most virus infections. An interdisciplinary research team at the Technical University of Munich (TUM) has now developed a new approach: they engulf and neutralize viruses with nano-capsules tailored from genetic material using the DNA origami ...
Versatile and reliable SARS-CoV-2 antibody assay
Automated microarray rapid test for detecting SARS-CoV-2 antibodies
28-Jun-2021
During the continued progression of the Corona pandemic, rapid, inexpensive, and reliable tests will become increasingly important to determine whether people have the associated antibodies – either through infection or vaccination. Researchers at the Technical University of Munich (TUM) have now ...
The Cut and Restore Protein Trick: Self-Excising Designer Proteins Report Isoform Expression
07-Jun-2021
Our proteome is much bigger than our genome because one gene produces several variants of proteins called protein isoforms, whose disbalance is implicated in many diseases. A new bioengineered reporter system developed at Helmholtz Zentrum München and the Technical University of Munich now allows ...
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