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Emergence of calorie burning fat cells

A new approach to treating overweight and obesity

10-Jan-2020

1.9 billion people in the world are overweight. Of these, 650 million people are obese, which increases the risk of secondary diseases such as high blood pressure or cancer. Professor Martin Klingenspor and his team at the Technical University of Munich (TUM) examine how our fat metabolism ...

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Looking at the good vibes of molecules: a new method for label-free metabolic imaging

09-Jan-2020

Label-free dynamic detection of biomolecules is a major challenge in live-cell microscopy. The simultaneous visualization of dynamic alterations for classes of metabolites, such as carbohydrates and lipids, was an unmet need in biomedical research. Now, a novel imaging method developed by a ...

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New algorithm detects even the smallest cancer metastases across the entire mouse body

Exposing the enemy

16-Dec-2019

Teams at Helmholtz Zentrum München, LMU Munich and the Technical University of Munich (TUM) have developed a new algorithm that enables automated detection of metastases at the level of single disseminated cancer cells in whole mice. Cancer is one of the leading causes of death worldwide. More ...

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Cancer: Inactive receptor renders immunotherapies ineffective

Important reason for poor response to checkpoint inhibitors identified

16-Oct-2019

The aim of immunotherapies is to enable the immune system once again to fight cancer on its own. Drugs known as checkpoint inhibitors are already in clinical use for this purpose. However, they are only effective in about one third of patients. Based on analysis of human tissue samples, a team ...

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ClpX-ClpP protein complex could be starting point for new antibiotics

Weak spot in pathogenic bacteria

08-Oct-2019

Antibiotics are still the most important weapon for combatting bacterial infections. But medical science is running out of “ammunition” because of more and more frequently occurring resistances. A research team has now elucidated the structure of the proteolytic complex ClpX-ClpP. This is a key ...

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Light in the nanoworld

Quantum light sources pave the way for optical circuits

06-Aug-2019

An international team headed up by Alexander Holleitner and Jonathan Finley, physicists at the Technical University of Munich (TUM), has succeeded in placing light sources in atomically thin material layers with an accuracy of just a few nanometers. The new method allows for a multitude of ...

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Activity of fuel cell catalysts doubled

Modelling leads to the optimum size for platinum fuel cell catalysts

04-Jul-2019

An interdisciplinary research team at the Technical University of Munich (TUM) has built platinum nanoparticles for catalysis in fuel cells: The new size-optimized catalysts are twice as good as the best process commercially available today. Fuel cells may well replace batteries as the power ...

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Tox "exhausts" immune cells

Molecular switch for reduced immune cell function discovered

19-Jun-2019

Tumors and certain viral infections pose a challenge to the human body which the immune system typically fails to hand. In these diseases it switches to hypofunctional state that prevent adequate protection. A research team from the Technical University of Munich (TUM) has achieved a major ...

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Efficient catalyst for water splitting

New hybrid semiconductor material for sustainable hydrogen production

20-May-2019

Chemists at the Technical University of Munich (TUM) have developed an efficient water splitting catalyst as part of a collaborative international research effort. The catalyst comprises a double-helix semiconductor structure encased in carbon nitride. It is perfect for producing hydrogen ...

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How plants defend themselves

Plant immune system detects bacteria through small fatty acid molecules

16-Apr-2019

Like humans and animals, plants defend themselves against pathogens with the help of their immune system. But how do they activate their cellular defenses? Researchers at the Technical University of Munich (TUM) have now discovered that receptors in plant cells identify bacteria through simple ...

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