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Pharmaceutical research: when active substance and target protein “embrace” each other

29-Jan-2021

Scientists at Goethe University Frankfurt, together with colleagues from Darmstadt, Heidelberg, Oxford and Dundee (UK), have investigated how the fit of potent inhibitors to their binding sites can be optimised so that they engage longer with their target proteins. Long target residency has been ...

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Folding of SARS-CoV2 genome reveals drug targets

Also preparation for “SARS-CoV3”

24-Nov-2020

For the first time, an international research alliance has observed the RNA folding structures of the SARS-CoV2 genome with which the virus controls the infection process. Since these structures are very similar among various beta corona viruses, the scientists not only laid the foundation for ...

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Possible Achilles’ heel of SARS-CoV-2 virus identified

Anti-viral strategy with double effect

31-Jul-2020

When the SARS-CoV-2 virus penetrates human cells, it lets the human host cell produce proteins for it. One of these viral proteins, called PLpro, is essential for the replication and rapid spread of the virus. An international team of researchers led by Goethe University and University Hospital ...

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How particulate matter arises from pollutant gases

International research project observes ultrafast particle growth through ammonia and nitric acid

15-May-2020

When winter smog takes over Asian mega-cities, more particulate matter is measured in the streets than expected. An international team, including researchers from Goethe University Frankfurt, as well as the universities in Vienna and Innsbruck, has now discovered that nitric acid and ammonia in ...

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Pool testing of SARS-CoV-02 samples increases worldwide test capacities many times over

01-Apr-2020

Researchers at the German Red Cross Blood Donor Service in Frankfurt headed by Professor Erhard Seifried, and the Institute for Medical Virology at the University Hospital Frankfurt at Goethe University headed by Professor Sandra Ciesek succeeded in developing a procedure that makes it possible ...

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Toxin responsible for Legionella growth identified

24-Jul-2019

A team of scientists led by EMBL group leader Sagar Bhogaraju and Ivan Dikic of Goethe University, Frankfurt, discovered that the toxin SidJ in Legionella bacteria enforces a unique modification on human proteins and helps legionella grow inside human cells. SidJ hijacks human protein Calmodulin ...

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Construction kit for custom-designed products

Biotechnologists develop robust and efficient methods for the production of new peptide drugs

13-Jun-2019

Microorganisms often assemble natural products similar to product assembly lines. Certain enzymes, non-ribosomal peptide synthetases (NRPS), play a key role in this process. Biotechnologists at Goethe University have now succeeded in changing these enzymes so that entirely new natural products, ...

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Inert Nitrogen Forced to React with Itself

26-Mar-2019

Direct coupling of two molecules of nitrogen: chemists from Würzburg and Frankfurt have achieved what was thought to be impossible. This new reaction is reported in Science magazine and opens new possibilities for one of the most inert molecules on earth. Constituting over 78 % of the air we ...

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Duplicate or mirror? Laser light determines chirality of molecules

19-Mar-2019

Seven of the ten most frequent medications contain chiral agents. These are molecules that occur in right- or left-handed forms. During chemical synthesis both forms usually occur in equal parts and have to be separated afterward, because chirality determines the agent’s effect in the body. ...

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Smart people have better connected brains

24-Nov-2017

Differences in intelligence have so far mostly been attributed to differences in specific brain regions. However, are smart people’s brains also wired differently to those of less intelligent persons? A new study published by researchers from Goethe University Frankfurt (Germany) supports this ...

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