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New insights into molecular mechanisms relevant for drug development

Simulations on biologically relevant time scales

12-Jun-2020

Molecular dynamics simulations (MD) have become an ubiquitous tool in modern life sciences. In these simulations, the interactions between atoms and molecules and their resulting spatial movements are iteratively calculated and analyzed. Scientists are currently trying to gain access to ...

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Innocent and highly oxidizing

Chemists produce new oxidants as a tool for preparative chemistry

04-Jun-2020

Chemical oxidation, the selective removal of electrons from a substrate, represents one of the most important transformations in chemistry. However, most common oxidants often show disadvantages such as undesired side reactions. The chemist Marcel Schorpp and colleagues from the group of Prof. ...

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Programming with the Light Switch

How to control individual components of self-assembling molecular structures

08-May-2020

In the development of autonomous systems and materials, self-assembling molecular structures controlled by chemical reaction networks are increasingly important. However, there is a lack of simple external mechanisms that ensure that the components of these reaction networks can be activated in a ...

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Coronavirus data analysis

Open source platform enables the free and transparent overview of COVID-19 genome informations

28-Feb-2020

Dr. Wolfgang Maier and Dr. Björn Grüning from the University of Freiburg, together with researchers from universities in Belgium, Australia and the USA, have reviewed the previously available data on sequences of the novel coronavirus and published their analyses on the open source platform ...

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Social control among immune cells improves defence against infections

This mechanism could improve immune therapies for cancer

13-Feb-2020

A simple mechanism, previously known from bacteria, ensures that the immune system strikes a balance between the rapid expansion of immune cells and the prevention of an excessive self-damaging reaction after an infection. This has now been deciphered by scientists at the University of Freiburg - ...

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Sweet Nanoparticles trick Kidney

Researchers engineer tiny particles with sugar molecules to prevent side effect in cancer therapy

06-Feb-2020

In the past decade nanomedicine has contributed to better detection and treatment of cancer. Nanoparticles are several 100 times smaller than the smallest grain of sand and can therefore easily travel in the blood stream to reach the tumor. However, they are still too big to be removed by the ...

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How the immune system becomes blind to cancer cells

04-Feb-2020

T cells play a huge role in our immune system's fight against modified cells in the body that can develop into cancer. Phagocytes and B cells identify changes in these cells and activate the T cells, which then start a full-blown program of destruction. This functions well in many cases - unless ...

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Bacterial Protein Impairs Important Cellular Processes

Researchers have discovered a new function of antibiotic resistant bacteria

19-Nov-2019

Areas of skin that have been damaged by an injury are ideal niches for the concentration of Pseudomonas aeruginosa, a bacterium which impairs the healing process in tissue and creates favorable conditions for infections. Because of its resistance to most available antibiotics, this bacterium is ...

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A question of time

How the immune system distinguishes between self molecules and non-self molecules such as those from pathogens

06-May-2019

A team led by the Freiburg biologists Prof. Dr. Wolfgang Schamel and Prof. Dr. Wilfried Weber conducted an experiment in which they controlled the duration of the interaction of a specific protein with T cells, a type of white blood cells, thereby showing how the immune system differentiates ...

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Traffic control of cells

Researchers develop a hydrogel whose stiffness and permeability to cells can be controlled with light

27-Mar-2019

Cells in the human body can display remarkable differences in their behaviour depending on the mechanical properties of the tissue surrounding them. This is especially true for immune cells, which migrate through the body and are thus constantly exposed to tissues with different properties and ...

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