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A remote control for gene transfer
Researchers develop technology to introduce genes into single cells in a targeted manner
18-Jun-2021
The ability to insert desirable genes into animal or human cells is the basis of modern life science research and of widespread biomedical applications. The methods used to date for this purpose are mostly non-specific, making it difficult for scientists to control which cell will or will not ...
A gene provides both protection and destruction
Researchers discover new function of the widely disseminated, yet little understood ENDOU enzyme
01-Mar-2021
The family of ENDOU enzymes is found in most organisms, yet its functions are only poorly understood. In humans, it has been connected with cancer. RNA viruses, such as SARS-CoV2, contain a gene corresponding to ENDOU, and this is important for virus replication and the suppression of the immune ...
Hierarchical dynamics
Researchers investigate signal transduction in proteins on many time scales
05-Feb-2021
A tree moving in the wind: How long does it take for the movement of a branch to reach the tree trunk? And via which pathway is this movement transmitted? Researchers at Albert Ludwig University are applying these questions to proteins, the molecular machinery of the cell. A team led by Prof. Dr. ...
A Small Protein in Bacteria Overlooked Up to Now
Researchers identify an essential factor involved in the ordered recycling of phycobilisome light-harvesting structures
02-Feb-2021
The biological process of photosynthesis is found at the beginning of nearly all food chains. It produces oxygen to breathe and provides the energetic foundation for using biotechnological processes to synthesize biofuels and chemical feedstock. Therefore, researchers are particularly interested ...
Common Vulnerabilities of Coronaviruses
International study maps molecular targets for possible therapy for MERS, SARS-CoV1, and SARS-CoV2
19-Oct-2020
In search of new drugs against COVID-19, a group of around 200 scientists is uncovering the molecular processes with which the coronaviruses MERS, SARS-CoV1, and SARS-CoV2 manipulate the host cell. The researchers from six countries have found 73 human proteins with which components of all three ...
Mechanism that causes cell nuclei to grow discovered
24-Sep-2020
By far the most important process in cell development is how cells divide and then enlarge in order to multiply. A research team headed by Freiburg medical scientist Prof. Dr. Robert Grosse has now discovered that bundled fibers of actin within a cell nucleus play an important part in how they ...
How Immune Cells Activate the Killer Mode
Researchers find missing link in immune response
22-Jul-2020
Unraveling a key motif: The T lymphocytes of the immune system work to destroy infected cells or cancer cells. To do so, they have to identify the threat: Molecules perceived as foreign – so-called antigens – bind to the T-cell receptor on the T cell surface. Now research groups led by Dr. Susana ...
New insights into molecular mechanisms relevant for drug development
Simulations on biologically relevant time scales
12-Jun-2020
Molecular dynamics simulations (MD) have become an ubiquitous tool in modern life sciences. In these simulations, the interactions between atoms and molecules and their resulting spatial movements are iteratively calculated and analyzed. Scientists are currently trying to gain access to ...
Innocent and highly oxidizing
Chemists produce new oxidants as a tool for preparative chemistry
04-Jun-2020
Chemical oxidation, the selective removal of electrons from a substrate, represents one of the most important transformations in chemistry. However, most common oxidants often show disadvantages such as undesired side reactions. The chemist Marcel Schorpp and colleagues from the group of Prof. ...
Programming with the Light Switch
How to control individual components of self-assembling molecular structures
08-May-2020
In the development of autonomous systems and materials, self-assembling molecular structures controlled by chemical reaction networks are increasingly important. However, there is a lack of simple external mechanisms that ensure that the components of these reaction networks can be activated in a ...
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