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Small-volume, high-throughput organic synthesis
New method synthesizes and evaluates large number of drug leads
11-Jul-2019
University of Groningen Professor of Drug Design, Alexander Dömling, has devised a method to rapidly synthesize thousands of new molecules and evaluate their properties as potential drugs. In a paper published by Science Advances on 5 July, he shows that this method works well when applied to ...
Optimized Binding Cavity
Directed evolution of a designer enzyme with an unnatural catalytic amino acid
05-Feb-2019
The impressively high conversion rates of natural enzymes partly result from increasing the catalytic activity of a selected few amino acid side chains through precise positioning within the protein binding cavity. Scientists have now demonstrated that such fine-tuning is also possible for ...
New method measures single molecules from nanoliter of blood in real time
09-Oct-2018
University of Groningen scientists, led by Associate Professor of Chemical Biology Giovanni Maglia, have designed a nanopore system that is capable of measuring different metabolites simultaneously in a variety of biological fluids, all in a matter of seconds. The electrical output signal is ...
New technique reveals causes of aging in yeast
03-Dec-2015
University of Groningen scientists have designed a unique experiment to study ageing in yeast cells. By following molecular processes inside ageing yeast, they discovered that an overproduction of the proteins needed to make new proteins could be the root cause of the cellular processes that ...
Building Scaffolds in the Cell’s Power Stations
Researchers at the University of Freiburg discover a basic architectural principle of mitochondria
08-May-2015
A group of scientists led by Assistant Professor Dr. Martin van der Laan has decoded the molecular basis for the characteristic structures inside of mitochondria. Mitochondria are the powerhouses of cells and contain microscopic, strongly infolded membrane structures. These structures allow ...
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