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14 Current news of Uni Kölnrss
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New function of a known defence mechanism discovered
Besides the skin, the digestive tract is the tissue that is most exposed to environmental influences such as bacteria and viruses. Therefore, cells that form these barriers to the interior of the body also have special defence mechanisms. A research team led by Professor Dr Thorsten Hoppe has now ...
Discovery could lead to new therapeutic approaches for Alzheimer’s and other protein-misfolding diseases
Researchers have identified a new function of a well-known enzyme: the signal peptidase complex is responsible for the quality control of membrane proteins. The discovery of this new function for a key enzyme in cell biology has been published in ‘Science’ and could lead to new therapeutic ...
Scientists have found that the protein CHIP can control life-prolonging signals in the cell better alone than in pairs
A new study shows that the protein CHIP can regulate the insulin receptor more efficiently alone than in a paired state. In cellular stress situations, CHIP usually appears as a homodimer - an association of two identical proteins - and primarily serves to degrade misfolded and defective ...
Two similar proteins can stand in for each other in the quality control mechanism of defective mRNA. This has redefined the distribution of protein tasks
Scientists led by Professor Dr Niels Gehring at the Institute for Genetics at the University of Cologne have investigated two similar proteins, UPF3A and UPF3B, which are involved in the quality control mechanism ‘nonsense-mediated mRNA decay’ (NMD). Their results show that both proteins are able ...
In large populations, mutants that evolve relatively late resist antibiotic treatment more effectively, while smaller populations rely on less effective mutations that appear at an earlier point in time
An international team of scientists at Wageningen University (Netherlands) and the Institute for Biological Physics at the University of Cologne (Germany) have shown that small and large bacterial populations follow qualitatively different evolutionary paths: Larger populations develop stronger ...
Understanding the basic mechanisms that lead to cell death is essential for the development of therapies for cancer and other diseases
Scientists led by Professor Ana J. Garcia-Saez at the CECAD Cluster of Excellence for Aging Research at the University of Cologne have shown that apoptosis, the programmed cell death, involves a direct physical interplay between the two proteins BAX and DRP1. DRP1 can serve as a direct cell death ...
The attachment of the small protein ubiquitin to other proteins regulates numerous biological processes, including signal transduction and metabolism
Scientists have discovered that the protein ubiquitin plays an important role in the regulation of the aging process. Ubiquitin was previously known to control numerous processes, such as signal transduction and metabolism. Prof. Dr. David Vilchez and his colleagues at the CECAD Cluster of ...
Protein balance in sex cells influences protein accumulation in other tissues through specific signaling
A recent study shows that a healthy reproductive system can prevent disease-related protein accumulation in distant tissues, such as neurons, and alteration of mitochondria - the power plants of cells. An imbalance of proteins, for example a build-up of damaged proteins in brain cells, can lead ...
An international research team has developed a model that predicts growth rates and resistance mechanisms of common bacterial mutants at different drug doses
A team of scientists from the University of Cologne (Germany) and the University of Uppsala (Sweden) has created a model that can describe and predict the evolution of antibiotic resistance in bacteria. Resistance to antibiotics evolves through a variety of mechanisms. A central and still ...
Findings will help catalyst research take an important step forward
“Titanium silicalite-1” (TS-1) is not a new catalyst: It has been almost 40 years since its development and the discovery of its ability to convert propylene into propylene oxide, an important basic chemical in the chemical industry. Now, by combining various methods, a team of scientists from ...
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