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An artificial cell on a chip

Efficient microfluidic technology produces tailor-made enzyme-loaded vesicles

29-Oct-2020

Researchers at the University of Basel have developed a precisely controllable system for mimicking biochemical reaction cascades in cells. Using microfluidic technology, they produce miniature polymeric reaction containers equipped with the desired properties. This “cell on a chip” is useful not ...

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How bacteria adhere to fiber in the gut

Two binding modes allow bacteria to stick to surfaces under flow

01-Sep-2020

Researchers have revealed a new molecular mechanism by which bacteria adhere to cellulose fibers in the human gut. Thanks to two different binding modes, they can withstand the shear forces in the body. Scientists of the University of Basel and ETH Zurich published their results in the journal ...

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Acetate regulates immune cells for a precisely orchestrated immune defense

Similar to a pressure valve, which prevents the pressure from rising to critical levels, the regulation of immune cells by acetate prevents the immune reaction from overshooting

07-Aug-2020

The concentration of acetate increases particularly sharply at the site of an infection in the body. As reported in the journal Cell Metabolism by a team of researchers from the University of Basel and colleagues, acetate supports the function of certain immune cells and thus helps to eliminate ...

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Protective shield: How pathogens withstand acidic environments in the body

Cell wall as a therapeutic target for the treatment of dangerous MRSA infections

07-May-2020

Certain bacteria, including the dangerous nosocomial pathogen MRSA, can protect themselves from acidic conditions in our body and thus ensure their survival. Researchers at the Biozentrum of the University of Basel have now elucidated an important mechanism in this process. A transport protein ...

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Perturbation-free studies of single molecules

New applications in the fields of quantum science, spectroscopy and chemistry

16-Mar-2020

Researchers of the University of Basel have developed a new method with which individual isolated molecules can be studied precisely – without destroying the molecule or even influencing its quantum state. This highly sensitive technique for probing molecules is widely applicable and paves the ...

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Virtual screening for active substances against the coronavirus

11-Mar-2020

The University of Basel is part of the global search for a drug to fight the rampant coronavirus. Researchers in the Computational Pharmacy group have so far virtually tested almost 700 million substances, targeting a specific site on the virus – with the aim of inhibiting its multiplication. Due ...

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Inner “clockwork” sets the time for cell division in bacteria

12-Feb-2020

Researchers at the Biozentrum of the University of Basel have discovered a “clockwork” mechanism that controls cell division in bacteria. In two publications, in “Nature Communications” und “PNAS”, they report how a small signaling molecule starts the “clock”, which informs the cell about the ...

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Kiss and run: How cells sort and recycle their components

30-Jan-2020

What can be reused and what can be disposed of? Cells also face this tricky task. Researchers from the Biozentrum of the University of Basel have now discovered a cellular machine, called FERARI, that sorts out usable proteins for recycling. In Nature Cell Biology, they explain how FERARI works ...

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Nanocontainers introduced into the nucleus of living cells

29-Jan-2020

An interdisciplinary team from the University of Basel has succeeded in creating a direct path for artificial nanocontainers to enter into the nucleus of living cells. To this end, they produced biocompatible polymer vesicles that can pass through the pores that decorate the membrane of the cell ...

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2D materials: arrangement of atoms measured in silicene

03-Jan-2020

Silicene consists of a single layer of silicon atoms. In contrast to the ultra-flat material graphene, which is made of carbon, silicene shows surface irregularities that influence its electronic properties. Now, physicists from the University of Basel have been able to precisely determine this ...

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